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mercaptomethyl-tetrazole
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Electrochemical Determination of Piroxicam at thin Carbon
Nanoparticle Composite And Investigation of the Electrochemical Behavior and Synthesis of Catechols in the Presence of Mercapto Methyl Tetrazol as a Nucleophile
,
M.Sc. Thesis
Sharif University of Technology
;
Shahrokhian, Saeed
(Supervisor)
Abstract
The electrochemical oxidation behavior of the anti-inflammatory drug piroxicam was investigated. A carbon nanoparticle (CNP)-chitosan (CS) film-coated graphite electrode (PGE) was fabricated and the electrochemical behaviors of piroxicam on its surface was investigated by the means of cyclic voltammetry (CV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS). In comparison to the bare PGE, at the surface of the CNP-CS film modified electrode, the oxidation peak current of piroxicam increased significantly and the peak potential shifted negatively. Consequently, a simple and sensitive electroanalytical method was developed for the determination of piroxicam. The...