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Improving bactericidal performance of implant composite coatings by synergism between Melittin and tetracycline
, Article Journal of Materials Science: Materials in Medicine ; Volume 33, Issue 6 , 2022 ; 09574530 (ISSN) ; Ghorbani, M ; Pooshang Bagheri, K ; Shokrgozar, M. A ; Sharif University of Technology
Springer
2022
Abstract
Methicillin resistance Staphylococcus aureus bacteria (MRSA) are serious hazards of bone implants. The present study was aimed to use the potential synergistic effects of Melittin and tetracycline to prevent MRSA associated bone implant infection. Chitosan/bioactive glass nanoparticles/tetracycline composite coatings were deposited on hydrothermally etched titanium substrate. Melittin was then coated on composite coatings by drop casting method. The surfaces were analyzed by FTIR, XRD, and SEM instruments. Tetracycline in coatings revealed multifunctional behaviors include bone regeneration and antibacterial activity. Releasing ALP enzyme from MC3T3 cells increased by tetracycline, so it is...