Sharif Digital Repository

Optical tweezers have proven to be indispensable micromanipulation tools especially in aqueous solutions. Because of the significantly larger spherical aberration induced by the refractive index mismatch, trapping aerosols has always been cumbersome if not impossible. We introduce a simple but very efficient method for optimized aerosol trapping at a desired depth. We show that a wise selection of the immersion medium and the mechanical tube length not only enables trapping of objects that are known to be untrappable but also provides a way to tune the trappable depth range  

Gold nanoparticles (GNPs) are very often used as handles for nanotechnological micromanipulation. In this regard, optical trapping of GNPs is of great importance, in which locating the trapped GNP within the focal spot with nanometer precision is crucial. Very recently, we have introduced a new position detection system for optical tweezers based on moiré deflectometry (MD). Here we show, both theoretically and experimentally, that an MD detection system could provide significantly larger detection sensitivity for a trapped GNP compared to that provided by conventional back focal plane (BFP) detection systems. For instance, for a trapped 200 nm GNP, the detection sensitivity provided by the... 

Optical tweezers are proven and indispensable micro-manipulation tools. It is very common to use an immersion-assisted high NA objective for optical trapping of micrometer-sized beads. However, such objectives suffer from low working depth range. Here we show, both by theory and experiment, that a dry objective can be utilized for optimal trapping of even sub-micrometer objects. For the first time, to the best of our knowledge, we were able to stably trap polystyrene beads with radii of 270 and 175 nm in 3D using an objective with numerical aperture of 0.9. © 2022 Optica Publishing Group  

The purpose of this paper is to design and analyze a 3-link micro-device proposed as a micro-manipulator. This micro-manipulator includes 3 micro-beams as links connected to one another with no conventional or flexural joints. While the structure of the micro-manipulator is monolithic, end-effector workspace is achieved through deflection of links which is actuated by piezoelectric layers. By combining static analysis of the links through a multilayer piezoelectric beam model and kinematic analysis of the micro-manipulator, inverse kinematic has been solved utilizing the Taylor series expansion technique and the perturbation method. The obtained results through the present model reveal that... 

Piezoelectric actuators are widely used in micro manipulation applications. However, hysteresis nonlinearity limits the accuracy of these actuators. This paper presents a novel approach for utilizing a piezoelectric nano-stage as the slave manipulator of a teleoperation system based on a sliding mode controller. The Prandtl-Ishlinskii (PI) model is used to model actuator hysteresis in feedforward scheme to cancel out this nonlinearity. The presented approach requires full state and force measurements at both the master and slave sides. Such a system is costly and also difficult to implement. Therefore, sliding mode unknown input observer (UIO) is proposed for full state and force... 

Optical tweezers are proven indispensable single-cell micro-manipulation and mechanical phenotyping tools. In this study, we have used optical tweezers for measuring the viscoelastic properties of human red blood cells (RBCs). Comparison of the viscoelastic features of the healthy fresh and atorvastatin treated cells revealed that the drug softens the cells. Using a simple modeling approach, we proposed a molecular model that explains the drug-induced softening of the RBC membrane. Our results suggest that direct interactions between the drug and cytoskeletal components underlie the drug-induced softening of the cells. © 2018 Optical Society of America