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    Microfluidic-based multi-organ platforms for drug discovery

    , Article Micromachines ; Volume 7, Issue 9 , 2016 ; 2072666X (ISSN) Rezaei Kolahchi, A ; Khadem Mohtaram, N ; Pezeshgi Modarres, H ; Mohammadi, M. H ; Geraili, A ; Jafari, P ; Akbari, M ; Sanati Nezhad, A ; Sharif University of Technology
    MDPI AG 
    Development of predictive multi-organ models before implementing costly clinical trials is central for screening the toxicity, efficacy, and side effects of new therapeutic agents. Despite significant efforts that have been recently made to develop biomimetic in vitro tissue models, the clinical application of such platforms is still far from reality. Recent advances in physiologically-based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling, micro- and nanotechnology, and in silico modeling have enabled single- and multi-organ platforms for investigation of new chemical agents and tissue-tissue interactions. This review provides an overview of the principles of designing... 

    Design of a hybrid inertial and magnetophoretic microfluidic device for ctcs separation from blood

    , Article Micromachines ; Volume 12, Issue 8 , 2021 ; 2072666X (ISSN) Nasiri, R ; Shamloo, A ; Akbari, J ; Sharif University of Technology
    MDPI AG  2021
    Circulating tumor cells (CTCs) isolation from a blood sample plays an important role in cancer diagnosis and treatment. Microfluidics offers a great potential for cancer cell separation from the blood. Among the microfluidic-based methods for CTC separation, the inertial method as a passive method and magnetic method as an active method are two efficient well-established methods. Here, we investigated the combination of these two methods to separate CTCs from a blood sample in a single chip. Firstly, numerical simulations were performed to analyze the fluid flow within the proposed channel, and the particle trajectories within the inertial cell separation unit were investigated to...