Sharif Digital Repository

Cell separation microfluidic devices have evolved into a multitude of biomedical and clinical research. Nonetheless, many critical issues remain in the way of achieving an excellent separation of target cells from a heterogeneous sample. Parallel to the abundant experimental studies related to the hybrid microfluidic methods, it is easy to perceive the lack of numerical investigations in order to optimize the separation process and its accuracy. In this study, for the first time to the best of our knowledge, a hybrid system by integrating acoustophoresis and pinched-flow fractionation (PFF) is proposed to achieve a viable system for a wide-range, precise separation. Employing the ultrasound... 

Infection is a disease that is mainly caused by different Gram-negative and Gram-positive bacteria. Treatment of infections requires a considerable amount of antibiotics, which can cause serious damage to the patient's body. Delivering the antibiotic only to the site of infection can prevent these destructive effects, such as the destruction of the normal intestinal flora. The drug delivery system through carriers will take antibiotics into a part of the body involved in the disease. Niosome nanoparticles, which have been made from non-ionic surfactants, have been emerging as ideal drug/antibiotics delivery vehicles. Recently, niosome formulations have been targeted to reduce toxicity and...