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    MiR-9-5p and miR-106a-5p dysregulated in CD4+ T-cells of multiple sclerosis patients and targeted essential factors of T helper17/regulatory T-cells differentiation

    , Article Iranian Journal of Basic Medical Sciences ; Volume 21, Issue 3 , March , 2018 , Pages 277-283 ; 20083866 (ISSN) Majd, M ; Hosseini, A ; Ghaedi, K ; Kiani Esfahani, A ; Tanhaei, S ; Shiralian Esfahani, H ; Rahnamaee, S. Y ; Mowla, S. J ; Nasr Esfahani, M. H ; Sharif University of Technology
    Mashhad University of Medical Sciences  2018
    Abstract
    Objective(s): Multiple sclerosis (MS) is considered as a chronic type of an inflammatory disease characterized by loss of myelin of CNS. Recent evidence indicates that Interleukin 17 (IL-17)-producing T helper cells (Th17 cells) population are increased and regulatory T cells (Treg cells) are decreased in MS. Despite extensive research in understanding the mechanism of Th17 and Treg differentiation, the role of microRNAs in MS is not completely understood. Thereby, as a step closer, we analyzed the expression profile of miR-9-5p and miR-106a-5p, and protein level of retinoic acid receptor (RAR)-related orphan receptor C (RORC; Th17 master transcription factor) as direct target of miR-106a-5p...