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    Simulation of Paramecium Chemotaxis Exposed to Calcium Gradients

    , Article Cell Biochemistry and Biophysics ; Volume 74, Issue 2 , 2016 , Pages 241-252 ; 10859195 (ISSN) Nematollahi Sarvestani, A ; Shamloo, A ; Ahmadian, M. T ; Sharif University of Technology
    Humana Press Inc  2016
    Abstract
    Paramecium or other ciliates have the potential to be utilized for minimally invasive surgery systems, making internal body organs accessible. Paramecium shows interesting responses to changes in the concentration of specific ions such as K+, Mg2+, and Ca2+ in the ambient fluid. Some specific responses are observed as, changes in beat pattern of cilia and swimming toward or apart from the ion source. Therefore developing a model for chemotactic motility of small organisms is necessary in order to control the directional movements of these microorganisms before testing them. In this article, we have developed a numerical model, investigating the effects of Ca2+ on swimming trajectory of... 

    A modular force-controlled robotic instrument for minimally invasive surgery – efficacy for being used in autonomous grasping against a variable pull force

    , Article International Journal of Medical Robotics and Computer Assisted Surgery ; Volume 12, Issue 4 , 2016 , Pages 620-633 ; 14785951 (ISSN) Khadem, S. M ; Behzadipour, S ; Mirbagheri, A ; Farahmand, F ; Sharif University of Technology
    John Wiley and Sons Ltd 
    Abstract
    Background: Many deficiencies of minimally invasive robotic surgery systems can be eliminated by using automated laparoscopic tools with force measurement and control capability. Method: A fully modular, automated laparoscopic instrument with a proximal force sensory system was designed and fabricated. The efficacy of the instrument was evaluated experimentally when functioning in an autonomous force-controlled grasping scheme. Results: The designed instrument was shown to work easily with standard laparoscopic tools, with the whole distal part detachable for autoclave sterilization. The root mean squared error (RMSE) of the actual pinch force from the target ramp was 0.318 N; it was 0.402 N... 

    A triple-jaw actuated and sensorized instrument for grasping large organs during minimally invasive robotic surgery

    , Article International Journal of Medical Robotics and Computer Assisted Surgery ; Volume 9, Issue 1 , 2013 , Pages 83-93 ; 14785951 (ISSN) Mirbagheri, A ; Farahmand, F ; Sharif University of Technology
    2013
    Abstract
    Background: Secure grasping and effective manipulation of delicate large organs during robotic surgery operations needs especially designed instruments that can enclose a large amount of tissue and feed back the pinch forces. Methods: A large organ triple-jaw grasper was instrumented using practical force sensory and actuating systems. A force tracking scheme was proposed to facilitate auto-grasping of large organs during robotic teleoperation surgery. An on-site force commanding/reflecting mechanism was also implemented to use the device as an independent hand-held robotic instrument. The efficacy of the robotic grasper was examined in phantom tests. Results: The instrument grasped large... 

    Review on different experimental techniques developed for recording force-deformation behaviour of soft tissues; with a view to surgery simulation applications

    , Article Journal of Medical Engineering and Technology ; Volume 41, Issue 4 , 2017 , Pages 257-274 ; 03091902 (ISSN) Afshari, E ; Rostami, M ; Farahmand, F ; Sharif University of Technology
    Abstract
    Different experimental techniques which have been developed to obtain data related to force-deformation behaviour of soft tissues play an important role in realistically simulating surgery processes as well as medical diagnoses and minimally invasive procedures. Indeed, an adequate quantitative description of soft-tissue-mechanical-behaviour requires high-quality experimental data to be obtained and analysed. In this review article we will first scan the motivations and basic technical issues on surgery simulation. Then, we will concentrate on different experimental techniques developed for recording force-deformation (stress-strain) behaviour of soft tissues with focussing on the in-vivo... 

    Modeling of the Flexible Instrument Inside the Vascular Environment for Its Motion Control in Minimally Invasive Procedures

    , M.Sc. Thesis Sharif University of Technology Rezazadeh, Taha (Author) ; Nejat Pishkenari, Hossein (Supervisor)
    Abstract
    Minimally invasive procedures are diagnostic or therapeutic methods that cause minimal injuries and side effects for patients. PCI is a common minimally invasive procedure for diagnosis and curing of cardiovascular disorders. In this procedure, the surgeon can have access to the cardiac vessels by a flexible instrument. However, motion control of this instrument inside the patient's body relies on surgeon's skills and in some cases, is time consuming so that the toxic effects of radiation on patient and surgical team increases. Magnetic flexible instruments are suggested to address this problem. Nevertheless, motion control of the flexible instrument inside the body still has many challenges... 

    Numerical analysis of ciliary beat in Paramecium: Increasing ciliary spacing as a low energy cost method for maneuvering

    , Article Recent Patents on Mechanical Engineering ; Volume 6, Issue 3 , September , 2013 , Pages 227-237 ; 1874477X (ISSN) Nematollahi, A ; Zand, M. M ; Sharif University of Technology
    2013
    Abstract
    In recent years, a number of patents have been devoted to designing micro robots for minimally invasive therapies inspired by Paramecium. Paramecium changes its swimming direction due to application of an external magnetic or electric field. Changing ciliary beat direction and frequency have been identified as possible methods for maneuvering through water; however, effects of variations in ciliary spacing on swimming trajectory have been poorly studied. In this work, it is aimed to analyze the effects of adjusting the ciliary spacing on swimming trajectory. For determining the swimming trajectory, Paramecium membrane is discretized to boundary elements with length of 15μm on which there are... 

    Analytical modeling of a Minimally Invasive Surgery grasper actuated by shape memory alloy wires

    , Article International Conference on Robotics and Mechatronics, ICRoM 2013 ; Feb , 2013 , Pages 147-151 ; 9781467358118 (ISBN) Shahriari, M ; Zabihollah, A ; Sharif University of Technology
    2013
    Abstract
    Minimally Invasive Surgery (MIS) is getting common these days. MIS robots using special tools can perform surgery precisely as humans. This is only possible with dexterous end-effectors and a well-controlled system. Local, lightweight and powerful actuators positioned at end-effectors provide the ability to decrease the degrees of freedom and simplify the design. This paper discusses a grasper design actuated by Shape Memory Alloy (SMA) wires that can be used in MIS robotics. The properties of a commercially available shape memory alloy are explored and analytical formulations for the actuation procedure are developed. The grasper actuated by SMA wires is studied and the procedure of... 

    Design of a force-reflective master robot for haptic telesurgery applications: RoboMaster1

    , Article Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS ; 2011 , Pages 7037-7040 ; 1557170X (ISSN) ; 9781424441211 (ISBN) Hadavand, M ; Mirbagheri, A ; Salarieh, H ; Farahmand, F ; Sharif University of Technology
    Abstract
    With the increasing trend toward Minimally Invasive Surgery (MIS) procedures, the need to develop new robotic systems to facilitate such surgeries is more and more recognized. This paper describes the design and development of a 4 DOF force-reflective master robot (RoboMaster1) for haptic telesurgery applications. A two-double parallelogram robot is introduced including a novel mechanism at the base for producing and control of the end effector's linear motion. This eliminates the deficiencies caused due to suspending massive actuators at the end effector or cabling from the base. The kinematics and work space of the system were analyzed and a prototype was developed for primary practical... 

    Automatic tracking of laparoscopic instruments for autonomous control of a cameraman robot

    , Article Minimally Invasive Therapy and Allied Technologies ; Volume 25, Issue 3 , 2016 , Pages 121-128 ; 13645706 (ISSN) Amini Khoiy, K ; Mirbagheri, A ; Farahmand, F ; Sharif University of Technology
    Taylor and Francis Ltd  2016
    Abstract
    Background An automated instrument tracking procedure was designed and developed for autonomous control of a cameraman robot during laparoscopic surgery. Material and methods The procedure was based on an innovative marker-free segmentation algorithm for detecting the tip of the surgical instruments in laparoscopic images. A compound measure of Saturation and Value components of HSV color space was incorporated that was enhanced further using the Hue component and some essential characteristics of the instrument segment, e.g., crossing the image boundaries. The procedure was then integrated into the controlling system of the RoboLens cameraman robot, within a triple-thread parallel... 

    Modeling and simulation of graspers force in minimally invasive surgery

    , Article 2009 International Association of Computer Science and Information Technology - Spring Conference, IACSIT-SC 2009, Singapore, 17 April 2009 through 20 April 2009 ; 2009 , Pages 475-479 ; 9780769536538 (ISBN) Hortamani, R ; Zabihollah, A ; Sharif University of Technology
    2009
    Abstract
    In Minimally Invasive Surgery (MIS) the operation is performed through introducing surgery instruments, graspers, scissor into the body. In the present work, a novel smart grasper is presented in which the surgeon can virtually acquire a feeling of force/momentum experienced by the organ/tissue. The smart grasper uses piezoelectric sensors bonded at desired locations to detect the applied force/momentum by surgeon and to measure the transmitted response to the tissue/organ. © 2009 IEEE  

    Design and Implementation of an Auto-Grasping Algorithm for a Robotic Laparoscopic Instrument

    , M.Sc. Thesis Sharif University of Technology Amirkhani, Golchehr (Author) ; Farahmand, Farzam (Supervisor)
    Abstract
    The main goal of this project is to design and implementation of the tissue auto-grasping algorithm for a wristed laparoscopic instrument. In this algorithm, the difference between the pinch forces of two jaws was taken into account when the pull force direction corresponding to the rod instrument direction was changed. The term ‘Tissue auto-grasping’ means automatic adjustment of the pinch force corresponding to the pull force exerted on the tissue by the robotic surgical instrument, so that slip and exerting excessive force on the tissue are prevented. In this study, obtaining the pinch force is based on the proximal force-sensing technique. For this reason, the force model of wristed... 

    A novel remote center of motion mechanism for the force-reflective master robot of haptic tele-surgery systems

    , Article International Journal of Medical Robotics and Computer Assisted Surgery ; Vol. 10, Issue. 2 , Jun , 2014 , pp. 129-139 ; ISSN: 14785951 Hadavand, M ; Mirbagheri, A ; Behzadipour, S ; Farahmand, F ; Sharif University of Technology
    Abstract
    Background: An effective master robot for haptic tele-surgery applications needs to provide a solution for the inversed movements of the surgical tool, in addition to sufficient workspace and manipulability, with minimal moving inertia. Method: A novel 4+1-DOF mechanism was proposed, based on a triple parallelogram linkage, which provided a Remote Center of Motion (RCM) at the back of the user's hand. The kinematics of the robot was analyzed and a prototype was fabricated and evaluated by experimental tests. Results: With a RCM at the back of the user's hand the actuators far from the end effector, the robot could produce the sensation of hand-inside surgery with minimal moving inertia. The... 

    Design of SMA micro-gripper for minimally invasive surgery

    , Article 2012 19th Iranian Conference of Biomedical Engineering, ICBME 2012 ; 2012 , Pages 97-100 ; 9781467331302 (ISBN) Adldoost, H ; Jouibary, B. R ; Zabihollah, A ; Sharif University of Technology
    2012
    Abstract
    Application of robotic instruments in minimally invasive surgery (MIS) has been developing in recent years. The urge to implement biocompatible and less invasive devices found way in use of materials like shape memory alloys. However such designs presented the idea of using heat control actuation in the MIS surgery and some have found noticeable position in robotic surgery. Yet the problems relating to insufficient stroke, slow motion and unfavorable generated heat have to be defeated. In this work it is focused to overcome these problems by a new design. Modern SMA grippers take advantage of two techniques: Net SMA and Spiral SMA. Both of these actuators demand application of high electric... 

    Conceptual design of a miniaturized hybrid local actuator for Minimally Invasive Robotic Surgery (MIRS) instruments

    , Article Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS ; 2011 , Pages 2140-2143 ; 1557170X (ISSN); 9781424441211 (ISBN) Saedi, S ; Mirbagheri, A ; Farahmand, F ; Sharif University of Technology
    Abstract
    The actuation mechanism of the tip of an endoscopic instrument is a major problem in designing miniature scale motorized instruments, especially when a high level of functionality and multi degrees of freedom (DOF) are concerned. We evaluated the different possible actuation methods for an endoscopic needle holder and proposed a new design of hybrid local-actuation, including a micro DC motor and a piezoelectric (PZT) actuator. The DC motor provided the long movement course required for opening-closing function of the gripper while the PZT guaranteed the high gripping force required for holding the needle. A compact serial configuration was considered for the actuators, producing an overall... 

    Finite element modeling of spleen tissue to analyze its interaction with a laparoscopic surgery instrument

    , Article ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis, ESDA2010, 12 July 2010 through 14 July 2010, Istanbul ; Volume 4 , 2010 , Pages 103-107 ; 9780791849187 (ISBN) Tirehdast, M ; Mirbagheri, A ; Farahmand, F ; Asghari, M ; Sharif University of Technology
    2010
    Abstract
    Laparoscopic surgery is a Minimally Invasive Surgery (MIS) procedure which is performed in the abdominal cavity. In this paper, the spleen tissue and a laparoscopic surgical grasper were modeled using ABAQUS software to investigate the tool-tissue interaction, considering large deformations for the spleen tissue. The spleen tissue was modeled as a hyper-elastic material. The laparoscopic grasper includes three gripping jaws that always remain parallel. The sliding can occur between the gripping jaws and the spleen tissue. It was found that the relationship between the pinch forces and push forces keeps its linearity in different values of friction coefficient (0-0.3). The pushing force... 

    Finding an unknown object by using piezeoelectric material: A finite element approach

    , Article 2nd International Conference on Environmental and Computer Science, ICECS 2009, 28 December 2009 through 30 December 2009, Dubai ; 2009 , Pages 156-160 ; 9780769539379 (ISBN) Azizi, A ; Durali, L ; Zareie, S ; Parvari Rad, F ; Sharif University of Technology
    IEEE  2009
    Abstract
    This paper presents a method to determine material of an unknown sample object. The main objective of this study is to design a database for specifying material of an object. We produce the database for different materials which is subjected to different forces. For this purpose we use a Polyvinidilene Fluoride (PVDF) sensor which is a piezoelectric material. Also we study the effect of changing place of sensor on our study. The detailed design was performed using finite element method analysis. Furthermore, if we have an object which we do not know its material by use of this database we can find out what this object is and how much its Yanoung's modules is. This study will be suitable for... 

    Dynamics of a magnetically rotated micro swimmer inspired by paramecium metachronal wave

    , Article Progress in Biophysics and Molecular Biology ; Volume 142 , 2019 , Pages 32-42 ; 00796107 (ISSN) Nematollahisarvestani, A ; Shamloo, A ; Sharif University of Technology
    Elsevier Ltd  2019
    Abstract
    In the past few years, a significant body of research has been devoted to designing magnetic micron scale robotic systems for minimally invasive medicine. The motion of different microorganisms is the nature's solution for efficient propulsion of these swimmers. So far, there has been a considerable effort in designing micro swimmers based on the propulsion of bacteria while the motion of numerous other microorganisms has not been a source of inspiration for designing micro swimmers yet. Inspired by propulsion of Paramecium which is a ciliate microorganism, a novel micro swimmer is proposed in this article which is capable of cargo transport. This novel swimmer is composed of multiple... 

    A minimally invasive robotic surgery approach to perform totally endoscopic coronary artery bypass on beating hearts

    , Article Medical Hypotheses ; Volume 124 , 2019 , Pages 76-83 ; 03069877 (ISSN) Alamdar, A ; Hanife, S ; Farahmand, F ; Behzadipour, S ; Mirbagheri, A ; Sharif University of Technology
    Churchill Livingstone  2019
    Abstract
    The currently available robotic systems rely on rigid heart stabilizers to perform totally endoscopic coronary artery bypass (TECAB) surgery on beating hearts. Although such stabilizers facilitate the anastomosis procedure by immobilizing the heart and holding the surgery site steady, they can cause damage to the heart tissue and rupture of the capillary vessels, due to applying relatively large pressures on the epicardium. In this paper, we propose an advanced robotic approach to perform TECAB on a beating heart with minimal invasiveness. The idea comes from the fact that the main pulsations of the heart occur as excursions in normal direction, i.e., perpendicular to the heart surface. We... 

    An extended algorithm for autonomous grasping of soft tissues during robotic surgery

    , Article International Journal of Medical Robotics and Computer Assisted Surgery ; Volume 16, Issue 5 , 2020 , Pages 1-15 Amirkhani, G ; Farahmand, F ; Yazdian, S. M ; Mirbagheri, A ; Sharif University of Technology
    John Wiley and Sons Ltd  2020
    Abstract
    Background: Autonomous grasping of soft tissues can facilitate the robotic surgery procedures. The previous attempts for implementing auto-grasping have been based on a simplistic representation of the actual surgery maneuvers. Method: A generalized three-zone grasp model was introduced to consider the effect of the pull force angulation on the grasp mode, that is, damage, slip, or safe grasp. Also, an extended auto-grasping algorithm was proposed in which the trigger force is automatically controlled against the pull force magnitude and direction, to achieve a safe and secure grasp. Results: The autonomous grasping experiments against a varying pull force in a phantom study indicated a good... 

    A computer model for evaluating the osteotomy parameters of Chiari pelvic osteotomy

    , Article International Orthopaedics ; Volume 34, Issue 3 , 2010 , Pages 329-333 ; 03412695 (ISSN) Karami, M ; Gouran Savadkoohi, D ; Ghadirpoor, A ; Rahimpoor, S ; Azghani, M ; Farahmand, F ; Sharif University of Technology
    2010
    Abstract
    This study was conducted to evaluate the effect of the various osteotomy parameters on the biomechanical aspects of the hip joint on a computerised model. The data of the radiographs and a three-dimensional (3D) CT scan of six patients with coverage deficient hip joint were used to construct a 3D computer model. Then Chiari type osteotomies were simulated using various heights, angles and fibrocartilage thicknesses. A new angle called the mid acetabular center edge (MACE) angle was defined in a mid coronal CT cut. The optimum displacement for obtaining the maximum coverage averaged 73%. The angle and height of the osteotomy had a significant effect on the MACE angle (P value∈<∈0. 01). Our...