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Hydrazine-modified starch coated magnetic nanoparticles as an effective pH-responsive nanocarrier for doxorubicin delivery
, Article Journal of Industrial and Engineering Chemistry ; Volume 39 , 2016 , Pages 203-209 ; 1226086X (ISSN) ; Hosseini, S. H ; Pourjavadi, A ; Sharif University of Technology
Korean Society of Industrial Engineering Chemistry
2016
Abstract
A novel, magnetic nanocarrier was successfully synthesized through a facile and economical producer in which Fe3O4 magnetic nanoparticles were coated by starch-g-poly (methyl methacrylate-co-PEG-acrylamide). The surface of nanocarrier was then modified by hydrazine to preparation of a pH-responsive carrier. The resulted nanocarrier was applied for delivery of doxorubicin (DOX) as an effective anti-cancer drug. DOX was reacted with hydrazine linkage on the surface of nanocarrier to form hydrazone bond. Due to the presence of numerous hydrazine groups on the surface of magnetic nanocarrier large amounts of DOX was loaded onto the carrier (327 mg g−1). © 2016 The Korean Society of Industrial...