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molecular-self-assembly
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Synthesis of new hybrid nanomaterials: Promising systems for cancer therapy
, Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 7, Issue 6 , 2011 , Pages 806-817 ; 15499634 (ISSN) ; Kalantari, M ; Parsamanesh, M ; Sadeghi, E ; Mahmoudi, M ; Sharif University of Technology
2011
Abstract
Polyrotaxanes consisting of cyclodextrin rings, polyethylene glycol axes and quantum dot (QD) stoppers were synthesized and characterized. The molecular self-assembly of polyrotaxanes led to spindlelike nano-objects whose shape, size and position were dominated by QD stoppers. Due to their well-defined molecular self-assemblies, carbohydrate backbone, high functionality and several types of functional groups together with the high luminescence yield, synthesized hybrid nanostructures were recognized as promising candidates for biomedical applications. The potential applications of the molecular self-assemblies as drug-delivery systems was investigated by conjugation of doxorubicin (DOX) to...
Polyrotaxane capped quantum dots as new candidates for cancer diagnosis and therapy
, Article Journal of Nanostructured Polymers and Nanocomposites ; Volume 7, Issue 1 , 2011 , Pages 18-31 ; 17904439 (ISSN) ; Sadeghi, E ; Hosseinkhani, H ; Mahmoudi, M ; Kalantari, M ; Adeli, M ; Sharif University of Technology
2011
Abstract
Molecular self-assembly of cadmium selenide quantum dots-end-capped polyrotaxane hybrid nanostructures (PRCdSe QDs) was led to a new type of core-shell hybrid nanomaterials consisting of cadmium selenide quantum dot (CdSe QDs) core and polyrotaxane shell (PR@QDs). Structure of PR@QDs was characterized using various techniques. It has been observed that the size of PR@QDs was between 20-25 nm in which diameter of core and thickness of shell were between 15-20 and 2-3 nm, respectively. Short-term in vitro cytotoxicity tests, using MTT (3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, were conducted on mouse tissue connective fibroblast adhesive cell line (L929) in order to...
Poly(citric acid)-block-poly(ethylene glycol) copolymers-new biocompatible hybrid materials for nanomedicine
, Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 6, Issue 4 , Aug , 2010 , Pages 556-562 ; 15499634 (ISSN) ; Adeli, M ; Vossoughi, M ; Sharif University of Technology
Abstract
Linear-dendritic ABA triblock copolymers containing poly(ethylene glycol) (PEG) as B block and hyperbranched poly(citric acid) (PCA) as A blocks were synthesized through polycondensation. The molecular self-assembly of synthesized PCA-PEG-PCA copolymers in water led to formation of nanoparticles and fibers in different sizes and shapes depending on the time and size of PCA blocks. Ten days after dissolving PCA-PEG-PCA copolymers in water, the size of fibers had reached several millimeters. Mixing a water solution of fluorescein as a small guest molecule and PCA-PEG-PCA copolymers led to the encapsulation of fluorescein by products of molecular self-assembly. To investigate their potential...