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    Erratum: Shock polar investigation in supersonic rarefied gas flows over a circular cylinder (Physics of Fluids (2021) 33 (052006) DOI: 10.1063/5.0050571)

    , Article Physics of Fluids ; Volume 33, Issue 6 , 2021 ; 10706631 (ISSN) Akhlaghi, H ; Roohi, E ; Daliri, A ; Soltani, M. R ; Sharif University of Technology
    American Institute of Physics Inc  2021
    This article was originally published online on 25May 2021 with the third author listed at the wrong affiliation. The affiliations appear correct above. All online versions of the article were corrected on 28 May 2021; the article is correct as it appears in the printed version of the journal. © 2021 American Institute of Physics Inc.. All rights reserved  

    Mortality response of folate receptor-activated, PEG-functionalized TiO2 nanoparticles for doxorubicin loading with and without ultraviolet irradiation

    , Article Ceramics International ; Vol. 40, issue. 4 , May , 2014 , pp. 5481-5488 ; ISSN: 02728842 Naghibi, S ; Madaah Hosseini, H. R ; Faghihi Sani, M. A ; Shokrgozar, M. A ; Mehrjoo, M ; Sharif University of Technology
    TiO2 nanoparticles (NPs) were synthesized by hydrothermal assisted sol-gel technique. In the next step, as-synthesized NPs were modified by poly ethylene glycol (PEG). Then, folic acid (FA) was conjugated to TiO 2-PEG. Finally, Doxorubicin (Dox) as an anticancer drug was loaded on as-prepared TiO2-PEG-FA nanocarrier. The optimization of TiO 2 and FA concentration and the influence of ultraviolet (UV) irradiation on photocatalytic activity of nanocarrier and Dox loaded carrier were assessed by utilizing the 3-(4,5-dimethylthiazol-2yl)-2,5- diphenyltetrazolium bromide (MTT)-assay method. Results indicated that the effect of NPs on cancer cells killing is dose-dependent, optimized at 1.25 g/L.... 

    In vitro study of bare and poly (ethylene glycol)-co-fumarate coated superparamagnetic iron oxide nanoparticles for reducing potential risks to humans and the environment

    , Article Handbook of Sustainable Energy ; May , 2011 , Pages 649-666 ; 9781608762637 (ISBN) Mahmoudi, M ; Simchi, A ; Imani, M ; Milani, A. S ; Stroeve, P ; Shivaee, H. A ; Sharif University of Technology
    Nova Science Publishers, Inc  2011
    For risk free application of nanoparticles in life science, energy and the environment, it is essential to understand their biological fate and potential toxicity. The application of iron oxide nanoparticles for drug delivery has been one of the most promising researches in the field of nanotechnology. However, there are two major problems associated with magnetically targeted deliveries that still need close attention: • As the drug is coated on to the particle surfaces, there is the possibility of faster drug release (Burst Effect). Therefore, after reaching to the specific site, there is very low amount of drug for delivery. To overcome this problem, some researchers have used conjugation... 

    Synthesis and Biological Evaluation of Superparamagnetic Iron Oxide Nanoparticles as Contrast Agents for Bioimaging Applications

    , M.Sc. Thesis Sharif University of Technology Ali Abouzar, Mitra (Author) ; Maddah Hosseini, Hamid (Supervisor) ; Oghabian, Mohammad Ali (Supervisor)
    A biocompatible ferrofluid containing ?Fe?_3 O_4 nanoparticles was produced using co precipitation of ?FeCl?_2.?4H?_(2 )O and ?FeCl?_3 ?6H?_2 O under ultrasonic irradiation power with NaOH being the alkaline. Two variables studied in this research were concentration and molecular weight of PEG, as the coating agent. The impact of these variables were carefully monitored on shape, size distribution and magnetic behavior of nanoparticles through SEM, DLS, XRD and VSM characterization techniques. Moreover, MRI relaxation times,T_1and T_2, were calculated using synthesized nanoparticles as contrast agents. Accordingly these nanoparticles were biologically evaluated by MTT assay. Results... 

    Electrophoretic Deposition of Alginate-Bioglass-Nanodiamond Nanocomposites and Evolution of their Bioactivity

    , M.Sc. Thesis Sharif University of Technology Mansoorianfar, Mojtaba (Author) ; Simchi, Abdollreza (Supervisor)
    Recently, diamond nanoparticles have attracted interest for biomedical applications such as drug delivery, targeted cancer therapies, fabrication of tissue scaffolds and biosensors. In the present work, elecrophoretic deposition (EPD) of nanodiamond-bioactive glass-alginate nanocomposite was studied. In vitro bioactivity and biocompatibility of the nanocomposite were evaluated in simulated body fluid (SBF) and by MTT assay. The EPD process was performed under different conditions in order to obtain a uniform coating on the surface of 316L stainless steel substrate. The stability of the suspension was determined via optical sedimentation method and zeta potential analysis. It was found that... 

    Cell life cycle effects of bare and coated superparamagnetic iron oxide nanoparticles

    , Article Toxic Effects of Nanomaterials ; 2012 , Pages 53-66 ; 9781608054213 (ISBN) Mahmoudi, M ; Laurent, S ; Journeay, W. S ; Sharif University of Technology
    Due to the hopeful potential of nanoparticles in medicine, they have attracted much attention for various applications such as targeted drug/gene delivery, separation or imaging. Interaction of NPs with the biological environment can lead to a wide range of cellular responses. In order to have safe NPs for biomedical applications, the current biocompatibility researches are particularly focused on the severe toxic mechanisms which cause cells death. These mechanisms are apoptosis, autophagy and necrosis, which can also be intricately linked with the cell-life cycle, as there are various check-points and controls in a cell's life cycle to ensure appropriate division processes. Mechanisms by... 

    The effects of thymus plant extracts on single breast cancer cell morphology in the microfluidic channel

    , Article 2018 IEEE EMBS Conference on Biomedical Engineering and Sciences, IECBES 2018, 3 December 2018 through 6 December 2018 ; 2019 , Pages 647-651 ; 9781538624715 (ISBN) Ahmad, M. R ; Mansor, M. A ; Alsadat Rad, M ; Soo-Beng Khoo, A ; Ahmad, M ; Marzuki, M ; Physiological Measurement; Sarawak Convention Bureau ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2019
    Microfluidics based systems could be useful for drug discovery as they allow for miniaturization and could potentially be run as multiple parallel cell based assays. Such miniaturization allows assays at single cell level and reduces the amount of test material needed, which, in the case of natural product extracts, simplifies the preparation. Thyme species extracts have been reported to show some promising anti-cancer effects. In the present work, we used a microfluidics based system to study the effects of Thymus kotschyanusm Boiss plant extract on two human breast cancer cells lines which are MDA-MB-231 and MCF-7. For better understanding a single cancer cell death mechanism and a flow... 

    Experimental Investigation on Growth and Control of Animal Cells Attached on Scaffold

    , M.Sc. Thesis Sharif University of Technology Solmaz, Naseri (Author) ; Vossoughi, Manoochehr (Supervisor) ; Alamzadeh, Iran (Co-Advisor)
    Major bone defects resulted from diseases or hurts that can not heal naturally, requaire bone transplantation. golden standard for transplantation is autologus one but it has some disad-vantages such as economic burden, the lack of graft source, surgery on patient, and so on. so exploring altrnative ways led to exploit stem cells.traditionally bone marrow mesenchymal stem cells (MSCs) used for stem cell-bsaed bone regeneration. bone marrow aspiration to aquaire stem cells is painfull and give a population of cells such as hematopoetic cells that requaire to seperate and can not be handled in first passages. MSCs can be substituted by multipotent adipose tissue-derived stem cells (ADSCs) in... 

    The controlled release of dexamethasone sodium phosphate from bioactive electrospun PCL/gelatin nanofiber scaffold

    , Article Iranian Journal of Pharmaceutical Research ; Volume 18, Issue 1 , 2019 , Pages 111-124 ; 17350328 (ISSN) Boroojeni, F. R ; Mashayekhan, S ; Abbaszadeh, H. A ; Sharif University of Technology
    Iranian Journal of Pharmaceutical Research  2019
    In this study, a system of dexamethasone sodium phosphate (DEXP)-loaded chitosan nanoparticles embedded in poly-ε-caprolacton (PCL) and gelatin electrospun nanofiber scaffold was introduced with potential therapeutic application for treatment of the nervous system. Besides anti-inflammatory properties, DEXP act through its glucocorticoid receptors, which are involved in the inhibition of astrocyte proliferation and microglial activation. Bovine serum albumin (BSA) was used to improve the encapsulation efficiency of DEXP within chitosan nanoparticles and to overcome its initial burst release. BSA incorporation within the chitosan nanoparticles increased the encapsulation efficiency of DEXP... 

    Ultrasonic-assisted synthesis of magnetite based MRI contrast agent using cysteine as the biocapping coating

    , Article Materials Chemistry and Physics ; Volume 131, Issue 1-2 , 2011 , Pages 170-177 ; 02540584 (ISSN) Ahmadi, R ; Malek, M ; Hosseini, H. R. M ; Shokrgozar, M. A ; Oghabian, M. A ; Masoudi, A ; Gu, N ; Zhang, Y ; Sharif University of Technology
    Magnetite nanoparticles (mean particle size ranging from 10 to 20 nm) were prepared by a biomoleculeassisted solution-phase approach under ultrasonic irradiation. Cysteine was used as the capping agent in the solution. The results show that cysteine could be an efficient biocapping agent in producing Fe3O4 nanoparticles. The crystal structure and magnetic properties of the nanoparticles were characterized by XRD and VSM techniques, respectively. FT-IR was used to investigate the presence of cysteine on the nanoparticles surface. The influence of pH value of the solution on the size distribution and hydrodynamic size of nanoparticles were studied by TEM and DLS methods, respectively. The MTT... 

    Cytotoxicity and cell cycle effects of bare and poly(vinyl alcohol)-coated iron oxide nanoparticles in mouse fibroblasts

    , Article Advanced Engineering Materials ; Volume 11, Issue 12 , 2009 , Pages B243-B250 ; 14381656 (ISSN) Mahmoudi, M ; Simchi, A ; Vali, H ; Imani, M ; Shokrgozar, M. A ; Azadmanesh, K ; Azari, F ; Sharif University of Technology
    Super-paramagnetic iron oxide nanoparticles (SPIONs) are recognized as powerful biocompatible materials for use in various biomedical applications, such as drug delivery, magnetic-resonance imaging, cell/protein separation, hyperthermia and transfection. This study investigates the impact of high concentrations of SPIONs on cytotoxicity and cell-cycle effects. The interactions of surfacesaturated (via interactions with cell medium) bare SPIONs and those coated with poly(vinyl alcohol) (PVA) with adhesive mouse fibroblast cells (L929) are investigated using an MTT assay. The two SPION formulations are synthesized using a co-precipitation method. The bare and coated magnetic nanoparticles with... 

    Fabrication of porous scaffolds with decellularized cartilage matrix for tissue engineering application

    , Article Biologicals ; Volume 48 , 2017 , Pages 39-46 ; 10451056 (ISSN) Nasiri, B ; Mashayekhan, S ; Sharif University of Technology
    Academic Press  2017
    Due to the avascular nature of articular cartilage, damaged tissue has little capacity for spontaneous healing. Three-dimensional scaffolds have potential for use in tissue engineering approach for cartilage repair. In this study, bovine cartilage tissue was decellularized and chemically crosslinked hybrid chitosan/extracellular matrix (ECM) scaffolds were fabricated with different ECM weight ratios by simple freeze drying method. Various properties of chitosan/ECM scaffolds such as microstructure, mechanical strength, swelling ratio, and biodegradability rate were investigated to confirm improved structural and biological characteristics of chitosan scaffolds in the presence of ECM. The... 

    Doxorubicin-conjugated D-glucosamine- and folate- bi-functionalised InP/ZnS quantum dots for cancer cells imaging and therapy

    , Article Journal of Drug Targeting ; Volume 26, Issue 3 , 2018 , Pages 267-277 ; 1061186X (ISSN) Ranjbar Navazi, Z ; Eskandani, M ; Johari Ahar, M ; Nemati, A ; Akbari, H ; Davaran, S ; Omidi, Y ; Sharif University of Technology
    Taylor and Francis Ltd  2018
    Nanoscaled quantum dots (QDs), with unique optical properties have been used for the development of theranostics. Here, InP/ZnS QDs were synthesised and functionalised with folate (QD-FA), D-glucosamine (QD-GA) or both (QD-FA-GA). The bi-functionalised QDs were further conjugated with doxorubicin (QD-FA-GA-DOX). Optimum Indium to fatty acid (In:MA) ratio was 1:3.5. Transmission electron microscopy (TEM) micrographs revealed spherical morphology for the QDs (11 nm). Energy-dispersive spectroscopy (EDS) spectrum confirmed the chemical composition of the QDs. MTT analysis in the OVCAR-3 cells treated with bare QDs, QD-FA, QD-GA, QD-FA-GA and QD-FA-GA-DOX (0.2 mg/mL of QDs) after 24 h indicated... 

    Magnetoelectric nanocomposite scaffold for high yield differentiation of mesenchymal stem cells to neural-like cells

    , Article Journal of Cellular Physiology ; Volume 234, Issue 8 , 2019 , Pages 13617-13628 ; 00219541 (ISSN) Esmaeili, E ; Soleimani, M ; Ghiass, M. A ; Hatamie, S ; Vakilian, S ; Zomorrod, M. S ; Sadeghzadeh, N ; Vossoughi, M ; Hosseinzadeh, S ; Sharif University of Technology
    Wiley-Liss Inc  2019
    While the differentiation factors have been widely used to differentiate mesenchymal stem cells (MSCs) into various cell types, they can cause harm at the same time. Therefore, it is beneficial to propose methods to differentiate MSCs without factors. Herein, magnetoelectric (ME) nanofibers were synthesized as the scaffold for the growth of MSCs and their differentiation into neural cells without factors. This nanocomposite takes the advantage of the synergies of the magnetostrictive filler, CoFe 2 O 4 nanoparticles (CFO), and piezoelectric polymer, polyvinylidene difluoride (PVDF). Graphene oxide nanosheets were decorated with CFO nanoparticles for a proper dispersion in the polymer through... 

    Niosomal delivery of simvastatin to MDA-MB-231 cancer cells

    , Article Drug Development and Industrial Pharmacy ; Volume 46, Issue 9 , 2020 , Pages 1535-1549 Akbarzadeh, I ; Saremi Poor, A ; Yaghmaei, S ; Norouzian, D ; Noorbazargan, H ; Saffar, S ; Ahangari Cohan, R ; Bakhshandeh, H ; Sharif University of Technology
    Taylor and Francis Ltd  2020
    Objective: The objective of this study was to use nano-niosomal formulations to deliver simvastatin as a poor-water soluble drug into breast cancer cells. Significance: Our study focused on the problem associated with poor water-soluble drugs which have significant biological activity in vivo. Methods: Different niosomal formulations of simvastatin were prepared and characterized in terms of morphology, size, encapsulation efficiency (EE), and release kinetic. Antiproliferative activity and the mechanism were assessed by quantitative real-time PCR and flow cytometry. Moreover, confocal microscopy was employed to analyze the cell uptake of simvastatin loaded niosomes to the cancerous cells.... 

    Synthesizing efficacious genistein in conjugation with superparamagnetic Fe3O4 decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma

    , Article Biomaterials Research ; Volume 24, Issue 1 , 2020 Ghasemi Goorbandi, R ; Mohammadi, M. R ; Malekzadeh, K ; Sharif University of Technology
    BioMed Central Ltd  2020
    Background: Genistein (C15H10O5) is a soy isoflavone with anti-cancer properties such as inhibition of cell growth, proliferation and tumor invasion, but effective dosage against hematopoietic malignant cells was not in non-toxic range. This property cause to impede its usage as chemotherapeutic agent. Therefore, this hypothesis raised that synthesizing biocompatible nanoparticle could assist to prevail this struggle. Methods: Genistein covalently attached on Fe3O4 nanoparticles decorated with carboxymethylated chitosan to fabricate Fe3O4-CMC-genistein in alkaline circumstance. This obtained nanoparticles were evaluated by TEM, DLS, FTIR, XRD and VSM and its anti-cancer effect by growth rate... 

    Synthesis of micelles based on chitosan functionalized with gold nanorods as a light sensitive drug delivery vehicle

    , Article International Journal of Biological Macromolecules ; Volume 149 , 2020 , Pages 809-818 Pourjavadi, A ; Bagherifard, M ; Doroudian, M ; Sharif University of Technology
    Elsevier B.V  2020
    This study aims to design photo-triggered micelles by using a natural base polymer. Chitosan was functionalized with thiourea, and in the next step, it was modified by grafting poly(L-lactide), poly(N-isopropylacrylamide), and poly(acrylamide) in determined ratio to form thermo-sensitive micelles. The sulfur content of chitosan@thiourea was measured about 2%. Grafting of polymers on chitosan was characterized by FT-IR and NMR techniques. The critical micellar concentration was measured by using photo luminescence spectroscopy. The size and surface morphology experiments revealed that average size of micelles is about 14 nm, and the length and width of GNRs are about 65 and 19 nm,... 

    Graphene oxide functionalized with oxygen-rich polymers as a pH-sensitive carrier for co-delivery of hydrophobic and hydrophilic drugs

    , Article Journal of Drug Delivery Science and Technology ; Volume 56 , 2020 Pourjavadi, A ; Asgari, S ; Hosseini, S. H ; Sharif University of Technology
    Editions de Sante  2020
    In this work, a novel carrier based-on modified graphene oxide was designed for co-delivery of hydrophobic and hydrophilic anticancer drugs (curcumin (Cur) and doxorubicin (DOX) as the model of drugs). The hydroxyl groups at the edges of graphene oxide (GO) sheets were used as the initiation sites for growing poly(epichlorohydrin) (PCH) chains. Then, hyperbranched polyglycerol (HPG) was grafted on the hydroxyl end groups of PCH (PCH-g-HPG). Pendant chlorines in the main chain of GO-PCH-g-HPG were replaced with hydrazine. The modification of GO sheets with oxygen-rich polymers increased water solubility of graphene oxide. Doxorubicin was loaded onto the nanocarrier by covalent bonding with... 

    Fabrication and evaluation of chitosan/gelatin/PVA hydrogel incorporating honey for wound healing applications: An in vitro, in vivo study

    , Article International Journal of Pharmaceutics ; Volume 592 , 2021 ; 03785173 (ISSN) Shamloo, A ; Aghababaie, Z ; Afjoul, H ; Jami, M ; Bidgoli, M. R ; Vossoughi, M ; Ramazani, A ; Kamyabhesari, K ; Sharif University of Technology
    Elsevier B.V  2021
    In this study, physically cross-linked hydrogels were developed by freezing-thawing method while different concentrations of honey were included into the hydrogels for accelerated wound healing. The hydrogel was composed of chitosan, polyvinyl alcohol (PVA), and gelatin with the ratio of 2:1:1 (v/v), respectively. Further, the effect of honey concentrations on antibacterial properties, and cell behavior was investigated. In vivo studies, including wound healing mechanism using rat model and histological analysis of section tissue samples were performed. The results illustrated that the incorporation of honey in hydrogels increased the ultimate strain of hydrogels approximately two times,... 

    Photoluminescent carbon quantum dot/poly-L-Lysine core-shell nanoparticles: A novel candidate for gene delivery

    , Article Journal of Drug Delivery Science and Technology ; Volume 61 , 2021 ; 17732247 (ISSN) Hasanzadeh, A ; Mofazzal Jahromi, M. A ; Abdoli, A ; Mohammad Beigi, H ; Fatahi, Y ; Nourizadeh, H ; Zare, H ; Kiani, J ; Radmanesh, F ; Rabiee, N ; Jahani, M ; Mombeiny, R ; Karimi, M ; Sharif University of Technology
    Editions de Sante  2021
    Cationic polymers such as poly-L-lysine (PLL) are able to interact electrostatically with DNA to produce polymeric systems with nanometric diameters due to the neutralization and accumulation of DNA. This study integrates the outstanding properties of carbon quantum dots (CQDs) with PLL to develop a novel gene delivery vehicle with a core-shell hybrid nanostructure. The CQD/PLL core-shell nanoparticles (NPs) were, therefore, synthesized in such a way that they had narrow size distribution and an average diameter under 10 nm, both of which were confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Fourier transform infrared (FTIR) spectroscopy exhibited that...