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    Multidisciplinary Design Optimization of a Nanorobot for Drug Delivery to Cancer Cells Based on Metaheuristic Algorithms

    , M.Sc. Thesis Sharif University of Technology Kazembeigi, Saeideh (Author) ; Abedian, Ali (Supervisor) ; Ghorbanian, Kaveh (Supervisor)
    Abstract
    This thesis is about multidisciplinary design optimization of MRI ¬controlled robots with a nonlinear model approach in the cardiovascular system and simulates its behavior to reach cancer cells. Such robots, designed to perform medical procedures with minimal side effects to the patient, include a set of ferromagnetic nanoparticles attached to the polymer and disposable drugs such as cancer drugs.The disciplines considered in this issue include structure, hydrodynamics, propulsion, controllability, and trajectory. The proposed model in this study, in addition to the main forces acting on the robot such as magnetic force, hydrodynamics, and apparent weight, also examines other forces due to... 

    Conceptual Design of a Solid Propellant Nanolauncher

    , M.Sc. Thesis Sharif University of Technology Ghadiri, Sajjad (Author) ; Farahani, Mohammad (Supervisor) ; Mohammadi, Alireza (Co-Supervisor)
    Abstract
    Nanolaunchers are launch vehicles capable of carring light payloads (under 50 kg) to Low Earth orbit and received much attention in the few past years. Launching the nanosatellites grown about 30 times from 2008 to 2017. Since this category of launch vehicles has fewer developing costs and lower thechnology level, they fit developing space technology in our country. Conversely, the demand of high propellant mass fraction and specific impulse may be a serious difficulty to attain this technology.The only operating nanolauncher in the world is SS-520-5 which belongs to Japan and is a three-stage solid propellant launcher. The goal of this project is also the conceptual design and feasiblity... 

    Multidisciplinary Design Optimization of an Air Launch Satellite Launch Vehicle by Considering the Coupled Slosh–vehicle Dynamics

    , M.Sc. Thesis Sharif University of Technology Keshavarz Mohammadian, Moein (Author) ; Fathi, Mohsen (Supervisor)
    Abstract
    In this thesis, the multidisciplinary design of liquid propellant satellite launch vehicle has been done by taking into consideration the effects of fuel sloshing. At first, the theory of multidisciplinary design and one-level architecture with the label of multidisciplinary feasibility have been used. In the following, Gravitational Search Algorithm (GSA) and Particle swarm optimization (PSO) have been developed. Then, the multidisciplinary design cycle began with the design of the liquid propellant system. In the propulsion section, the selection of the optimal fuel, the design of the nozzle, motor and the selection of the optimal engine cycle considering the geometric and mass... 

    Reliability-Based Multidisciplinary Design Optimization Under Uncertainty for Reusable Flexible Launch Vehicle Using Genetic Algorithm

    , M.Sc. Thesis Sharif University of Technology Mojibi, Motahareh (Author) ; Fathi Jegarkandi, Mohsen (Supervisor)
    Abstract
    In this research, a Reusable Flexible Launch Vehicle (RFLV) design problem is presented by Multi-Disciplinary Design Optimization (MDO) approach in primary design phase. Trajectory, structure, aerodynamic, aeroelasticity and thermal protection system are considered as involved disciplines in design problem. The study purpose will be to obtain an optimal trajectory which meets all the control and structure limitation while the estimating body skin and thermal protection thicknesses base on structural evaluating in re-entry trajectory is in process. The flexible launch vehicle body is considered as a free-free Bernoulli-Euler beam and D’alembert’s principle addresses inertia force in static... 

    Improving the Decision-Making Process under the Presence of Uncertainty in Airplane Conceptual Design, Creating an Intuitive Platform

    , M.Sc. Thesis Sharif University of Technology Gholinejhad, Nargess (Author) ; Banazadeh, Afshin (Supervisor)
    Abstract
    Improving performance and reducing costs is a constant competition between aircraft designers, which has made multi-disciplinary optimization always part of the design process. In the design process of a conventional aircraft, there are various uncertainties in technology levels, mission parameters, costs and operating environment. It is clear that these uncertainties will make the decision-making difficult and lead to uncertainties in the output of the design; on the other hand, considering them will increase the computational cost. Understanding how much the uncertainty of each parameter will affect the overall output of the design and its performance, makes it possible to ignore the... 

    Performance optimization of the helical heat exchanger with turbulator

    , Article Frontiers in Energy Research ; Volume 9 , 2022 ; 2296598X (ISSN) Xifeng, W ; Xiaoluan, Z ; Mahariq, I ; Salem, M ; Ghalandari, M ; Ghadak, F ; Abedini, M ; Sharif University of Technology
    Frontiers Media S.A  2022
    Abstract
    In this paper, optimization on a two-tube helical heat exchanger with a fin is represented. The spiral pipes heat exchanger which is made of the cooper is adopted for investigation. The effects of three types of fins with the proposed geometric shapes on the overall heat transfer coefficient and pressure loss are investigated. The fins are located on the inner surface of the outer pipe. The obtained numerical results are compared with the experimental results, and a good agreement is observed between the results. The studies show that the total heat transfer coefficient has increased by 170% compared to an exchanger with no fin. Therefore, the best fin has been selected based on the...