Sharif Digital Repository

Herein, we report an efficient one-pot four-component reaction of commercially available 1,3-dicarbonyl compounds, aromatic aldehydes, amines, and nitromethane in the presence of ZnO nanoparticles, which leads to highly substituted pyrroles in moderate to good yields. A mild and efficient tandem process for the synthesis of highly substituted α-pyrones starting from 2-arylacetic acid of high com-mercial availability has been developed. The synthesis is based on the Knoevenagel condensation of 1,3-cyclohexadiones to various β-keto-Esters, followed by lactonization in the presence of 20 mol% ZnO as a nanocatalyst. Moderate to high yields, easily available and less expensive starting materials... 

In the first chapter, high substituted pyrrole derivaitives were synthesized through a one pot four compounent reaction using carbonyl and amin compounds at the presence of magnetic nanoparticles of superparamagnetic ferrospinel NiFe2O4nanoparticles as catalyst.In the second chapter, NiFe2O4magnetic nanoparticles were employed in the Sonogashira reactions using phenyl acetylene as coupling partner with different types of aryle and alkyl halides in water as a green solvent. The results of these reactions were considered comprehensively  

In first part Mesoporous silica (SBA-15) was synthesized by template synthesis method and the surface of SBA-15 was functionalized with 3-glycidoxypropyltrimethoxysilane and 5-Phenyl-1H-tetrazole. Palladium nanoparticles were immobilized on the aforementioned mesoporous support. Characterization of catalyst regarding to its structure, morphology and other parameters was investigated by physiochemical analysis such as XRD, SEM, TEM, and TGA. This heterogeneous catalyst has high capability in reduction of nitrobenzenes and selective oxidation of primary alcohols which respectively gain aminoarenes and benzaldehydes in high yields. Reduction and oxidation reactions are done in water as a green... 

Nowadays, using one-pot multicomponent reactions in the synthesis of organic and natural compounds has attracted a lot of attention due to their ideal synthetic features. These types of reactions play an important role in synthetic chemistry by reducing reaction steps, costs, wastes, and by-products and increasing the reaction efficiency as an efficient method. The issue that led to this project was the development of a novel procedure for developing synthetic methods for the synthesis of thioxo-pyrrolidine 3-carbutamide compounds. In this study, the first Mumm rearrangement was performed by using dithiocarbamates by applying ultrasonic irradiation. The reaction was investigated in methanol... 

Nowadays, heterocyclic compounds have become extremely important in various industries, especially the pharmaceutical industry.In this project, an efficient and environmentally friendly path is presented to synthesize numerous rhodanine-oxindole derivatives in polyethylene Glycol in one pot-four components procedure. This pathway doesn't need harsh reaction conditions such as high temperature, long time, catalysts, complicated separation steps, toxic solvents, etc. all products have been made under green strategy with high yield.
 

An efficient one-pot procedure is described for the synthesis of derivatives of 3,4-Dihydrochromen-2-ones under solvent-free and metal-free conditions via a pseudo-four-component domino reaction of acetic anhydride, aryl aldehydes, glycine-based dithiocarbamates, and phenols/naphthols. All products were made under green strategy with high yields

 

In the first part of this thesis provided an efficient and easy method for the synthesis of 3-alkylidin-2-oxindoles containing tetrahydropyrazine structure in the absence of catalysts under green conditions. The oxindole unit represents an important structural motif found in natural products and biologically relevant compounds. On the other hand, pyrazines are important and well-known compounds found in nature and many medicinal compounds. According to the aforementioned, it seems that the oxindole compounds containing the pyrazine rings exhibit high biological activity.In the second chapter of this thesis, an efficient study to synthesize thiopyrano [2,3-b] quinoline containing indole... 

In the first section, due to the important role of nanocatalysts in different fields of chemistry, magnetic metal ferrite nanoparticles were synthesized. Ferrite nanoparticles were synthesized using co-precipitation method and were characterized. Then, these nanoparticles were applied as catalyst system for one-pot β-ketophosphonates and thiophosphate synthesis.This is a green and efficient route for S-P and C-P bond construction using copper ferrite nanoparticles as catalyst. The application of a highly active recyclable heterogeneous nanocopper ferrite catalyst for the oxyphosphorylation reaction of various alkenes was conducted under ligand-free conditions, in acetonitrile as solvent at... 

In the first section, a novel and efficient multicomponent reaction for the synthesis of polysubstituted pyrrolidine derivatives is described under catalyst-free conditions using unltrasonic irradiation. The reactions were performed via a one-pot four-component condensation of secondary amines, carbon disulfide, isocyanides, and gem-dicyano olefins at room temperature to afford polysubstituted pyrrolidines diastereoselectively in 56-96% yields. This is the first report of Mumm-type rearrangement with dithiocarbamates followed by intramolecular cyclization which lead to the preparation of the key structure of pyrrolidine.In the second section, an efficient and unprecedented green protocol...