Search for: multiple-sclerosis
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    Sensing of alzheimer's disease and multiple sclerosis using nano-bio interfaces

    , Article Journal of Alzheimer's Disease ; Volume 59, Issue 4 , 2017 , Pages 1187-1202 ; 13872877 (ISSN) Hajipour, M. J ; Ghasemi, F ; Aghaverdi, H ; Raoufi, M ; Linnef, U ; Atyabi, F ; Nabipour, I ; Azhdarzadeh, M ; Derakhshankhah, H ; Lotfabadi, A ; Bargahi, A ; Alekhamis, Z ; Aghaie, A ; Hashemi, E ; Tafakhori, A ; Aghamollaii, V ; Mashhadi, M. M ; Sheibani, S ; Vali, H ; Mahmoudi, M ; Sharif University of Technology
    It is well understood that patients with different diseases may have a variety of specific proteins (e.g., type, amount, and configuration) in their plasmas. When nanoparticles (NPs) are exposed to these plasmas, the resulting coronas may incorporate some of the disease-specific proteins. Using gold (Au) NPs with different surface properties and corona composition, we have developed a technology for the discrimination and detection of two neurodegenerative diseases, Alzheimer's disease (AD) and multiple sclerosis (MS). Applying a variety of techniques, including UV-visible spectra, colorimetric response analyses and liquid chromatography-tandem mass spectrometry, we found the corona-NP... 

    A metabonomics investigation of multiple sclerosis by nuclear magnetic resonance

    , Article Magnetic Resonance in Chemistry ; Volume 51, Issue 2 , DEC , 2013 , Pages 102-109 ; 07491581 (ISSN) Mehrpour, M ; Kyani, A ; Tafazzoli, M ; Fathi, F ; Joghataie, M. T ; Sharif University of Technology
    Multiple sclerosis (MS) is a nervous system disease that affects the fatty myelin sheaths around the axons of the brain and spinal cord, leading to demyelination and a broad range of signs and symptoms. MS can be difficult to diagnose because its signs and symptoms may be similar to other medical problems. To find out which metabolites in serum are effective for the diagnosis of MS, we utilized metabolic profiling using proton nuclear magnetic resonance spectroscopy (1H-NMR). Random forest (RF) was used to classify the MS patients and healthy subjects. Atomic absorption spectroscopy was used to measure the serum levels of selenium. The results showed that the levels of selenium were lower in... 

    Multiple sclerosis diagnosis based on analysis of subbands of 2-D wavelet transform applied on MR-images

    , Article 2007 IEEE/ACS International Conference on Computer Systems and Applications, AICCSA 2007, Amman, 13 May 2007 through 16 May 2007 ; 2007 , Pages 717-721 ; 1424410312 (ISBN); 9781424410316 (ISBN) Torabi, M ; Moradzadeh, H ; Vaziri, R ; Dehestani Ardekani, R ; Fatemizadeh, E ; Sharif University of Technology
    In this study, we have proposed a novel approach to investigate the features of four subbands of 2-D wavelet transform in magnetic resonance images (MRIs) for normal and abnormal brains which defected by Multiple Sclerosis (MS). Concurrently, another method extracts different kinds of features in spatial domain. Totally, 116 features have been extracted. Before applying the algorithm, we have to use a registration method because of variety in size of brain images. All extracted features have been passed over the Principal Component Analysis (PCA) and have been pushed to an Artificial Neural Network (ANN) that is a feed-forward type. According to changing in position of defected parts of... 

    Nonlinear dynamical structure of sway path during standing in patients with multiple sclerosis and in healthy controls is affected by changes in sensory input and cognitive load

    , Article Neuroscience Letters ; Volume 553 , 2013 , Pages 126-131 ; 03043940 (ISSN) Negahban, H ; Sanjari, M. A ; Mofateh, R ; Parnianpour, M ; Sharif University of Technology
    Although several studies have applied traditional linear measures to evaluate postural control of patients with multiple sclerosis (MS), little is known about the nonlinear dynamics of this patient group. In this study, recurrence quantification analysis (RQA), a well documented nonlinear method, was used to compare the nonlinear dynamical structure of postural sway in two groups consisting of MS patients (. n=. 23) and healthy matched controls (. n=. 23). The study focuses on three levels of postural difficulty consisting of (1) standing on a rigid surface (force platform) with eyes open, (2) standing on a rigid surface with eyes closed, and (3) standing on a foam surface with eyes closed.... 

    Channelopathy-related SCN10A gene variants predict cerebellar dysfunction in multiple sclerosis

    , Article Neurology ; Volume 86, Issue 5 , 2016 , Pages 410-417 ; 00283878 (ISSN) Roostaei, T ; Sadaghiani, S ; Park, M. T. M ; Mashhadi, R ; Nazeri, A ; Noshad, S ; Salehi, M. J ; Naghibzadeh, M ; Moghadasi, A. N ; Owji, M ; Doosti, R ; Hashemi Taheri, A. P ; Rad, A. S ; Azimi, A ; Chakravarty, M. M ; Voineskos, A. N ; Nazeri, A ; Sahraian, M. A ; Sharif University of Technology
    Lippincott Williams and Wilkins 
    Objective: To determine the motor-behavioral and neural correlates of putative functional common variants in the sodium-channel NaV1.8 encoding gene (SCN10A) in vivo in patients with multiple sclerosis (MS). Methods: We recruited 161 patients with relapsing-onset MS and 94 demographically comparable healthy participants. All patients with MS underwent structural MRI and clinical examinations (Expanded Disability Status Scale [EDSS] and Multiple Sclerosis Functional Composite [MSFC]). Whole-brain voxel-wise and cerebellar volumetry were performed to assess differences in regional brain volumes between genotype groups. Resting-state fMRI was acquired from 62 patients with MS to evaluate... 

    Protein fibrillation and nanoparticle interactions: Opportunities and challenges

    , Article Nanoscale ; Volume 5, Issue 7 , Jan , 2013 , Pages 2570-2588 ; 20403364 (ISSN) Mahmoudi, M ; Kalhor, H. R ; Laurent, S ; Lynch, I ; Sharif University of Technology
    Due to their ultra-small size, nanoparticles (NPs) have distinct properties compared with the bulk form of the same materials. These properties are rapidly revolutionizing many areas of medicine and technology. NPs are recognized as promising and powerful tools to fight against the human brain diseases such as multiple sclerosis or Alzheimer's disease. In this review, after an introductory part on the nature of protein fibrillation and the existing approaches for its investigations, the effects of NPs on the fibrillation process have been considered. More specifically, the role of biophysicochemical properties of NPs, which define their affinity for protein monomers, unfolded monomers,... 

    Application of artificial neural network for prediction of risk of multiple sclerosis based on single nucleotide polymorphism genotypes

    , Article Journal of Molecular Neuroscience ; Volume 70, Issue 7 , 2020 , Pages 1081-1087 Ghafouri-Fard, S ; Taheri, M ; Omrani, M. D ; Daaee, A ; Mohammad Rahimi, H ; Sharif University of Technology
    Humana Press Inc  2020
    The artificial neural network (ANN) is a sort of machine learning method which has been used in determination of risk of human disorders. In the current investigation, we have created an ANN and trained it based on the genetic data of 401 multiple sclerosis (MS) patients and 390 healthy subjects. Single nucleotide polymorphisms (SNPs) within ANRIL (rs1333045, rs1333048, rs4977574 and rs10757278), EVI5 (rs6680578, rs10735781 and rs11810217), ACE (rs4359 and rs1799752), MALAT1 (rs619586 and rs3200401), GAS5 (rs2067079 and rs6790), H19 (rs2839698 and rs217727), NINJ2 (rs11833579 and rs3809263), GRM7 (rs6782011 and rs779867), VLA4 (rs1143676), CBLB (rs12487066) and VEGFA (rs3025039 and... 

    MiR-9-5p and miR-106a-5p dysregulated in CD4+ T-cells of multiple sclerosis patients and targeted essential factors of T helper17/regulatory T-cells differentiation

    , Article Iranian Journal of Basic Medical Sciences ; Volume 21, Issue 3 , March , 2018 , Pages 277-283 ; 20083866 (ISSN) Majd, M ; Hosseini, A ; Ghaedi, K ; Kiani Esfahani, A ; Tanhaei, S ; Shiralian Esfahani, H ; Rahnamaee, S. Y ; Mowla, S. J ; Nasr Esfahani, M. H ; Sharif University of Technology
    Mashhad University of Medical Sciences  2018
    Objective(s): Multiple sclerosis (MS) is considered as a chronic type of an inflammatory disease characterized by loss of myelin of CNS. Recent evidence indicates that Interleukin 17 (IL-17)-producing T helper cells (Th17 cells) population are increased and regulatory T cells (Treg cells) are decreased in MS. Despite extensive research in understanding the mechanism of Th17 and Treg differentiation, the role of microRNAs in MS is not completely understood. Thereby, as a step closer, we analyzed the expression profile of miR-9-5p and miR-106a-5p, and protein level of retinoic acid receptor (RAR)-related orphan receptor C (RORC; Th17 master transcription factor) as direct target of miR-106a-5p...