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Stereoselective synthesis ofβ-Amino ketones via direct mannich-type reaction catalyzed with SO 2- 4/TiO 2 and SO 2- 4/nano TiO 2
, Article Synthetic Communications ; Volume 39, Issue 24 , 2009 , Pages 4441-4453 ; 00397911 (ISSN) ; Eftekhari Sis, B ; Mahmodi Hashemi, M ; Farmad, F ; Sharif University of Technology
2009
Abstract
At room temperature, SO 2- 4/nano-TiO 2 efficiently catalyze the direct Mannich-type reaction of varieties of in situ-generated aldimines using aldehydes and anilines with ketones in a three-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the correspondingβ-amino ketones in good to high yields with good to excellent stereoselectivity. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency