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nanobubbles
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The Synthesis of Graphene-Nanobubbles and Investigation of their Potential Synergistic Effect on Bacterial Cells
, Ph.D. Dissertation Sharif University of Technology ; Akhavan, Omid (Supervisor) ; Maddah Hosseini, Hamid Reza (Supervisor) ; Bakhsi, Bita (Co-Supervisor)
Abstract
Recently, nanotechnology has promised to create and/ or improve therapeutic methods which in turn remain minimum side effects by employing synergistic effects of nanostructures. However, a comprehensive understanding of the interactions between nanostructures and building blocks of the biological systems (cells) is essential to create innovative therapeutic methods and compound and also predict their behavior for upcoming applications. In this thesis for the first time, synergistic effects of graphene-nanobubbles in interactions with bacterial (as the simplest model) cells were investigated. Therefore, at the first step, production of nanobubbles (NBs) in the presence of two-dimensional...
Review of oxygenation with nanobubbles: possible treatment for hypoxic covid-19 patients
, Article ACS Applied Nano Materials ; Volume 4, Issue 11 , 2021 , Pages 11386-11412 ; 25740970 (ISSN) ; Akhavan, O ; Hamblin, M. R ; Varma, R. S ; Sharif University of Technology
American Chemical Society
2021
Abstract
The coronavirus disease (COVID-19) pandemic, which has spread around the world, caused the death of many affected patients, partly because of the lack of oxygen arising from impaired respiration or blood circulation. Thus, maintaining an appropriate level of oxygen in the patients' blood by devising alternatives to ventilator systems is a top priority goal for clinicians. The present review highlights the ever-increasing application of nanobubbles (NBs), miniature gaseous vesicles, for the oxygenation of hypoxic patients. Oxygen-containing NBs can exert a range of beneficial physiologic and pharmacologic effects that include tissue oxygenation, as well as tissue repair mechanisms,...
Review of Oxygenation with Nanobubbles: Possible Treatment for Hypoxic COVID-19 Patients
, Article ACS Applied Nano Materials ; Volume 4, Issue 11 , 2021 , Pages 11386-11412 ; 25740970 (ISSN) ; Akhavan, O ; Hamblin, M. R ; Varma, R. S ; Sharif University of Technology
American Chemical Society
2021
Abstract
The coronavirus disease (COVID-19) pandemic, which has spread around the world, caused the death of many affected patients, partly because of the lack of oxygen arising from impaired respiration or blood circulation. Thus, maintaining an appropriate level of oxygen in the patients' blood by devising alternatives to ventilator systems is a top priority goal for clinicians. The present review highlights the ever-increasing application of nanobubbles (NBs), miniature gaseous vesicles, for the oxygenation of hypoxic patients. Oxygen-containing NBs can exert a range of beneficial physiologic and pharmacologic effects that include tissue oxygenation, as well as tissue repair mechanisms,...
Graphene jet nanomotors in remote controllable self-Propulsion swimmers in pure water
, Article Nano Letters ; Volume 16, Issue 9 , 2016 , Pages 5619-5630 ; 15306984 (ISSN) ; Saadati, M ; Jannesari, M ; Sharif University of Technology
American Chemical Society
Abstract
A remote controllable working graphite nanostructured swimmer based on a graphene jet nanomotor has been demonstrated for the first time. Graphite particles with pyramidal-like morphologies were fabricated by the creation of suitable defects in wide high-purity graphite flakes followed by a severe sonication. The particles were able to be self-exfoliated in water after Na intercalation between the graphene constituents. The self-exfoliation resulted in jet ejection of graphene flakes from the end of the swimmers (with speeds as high as ∼7000 m/s), producing a driving force (at least ∼0.7 L (pN) where L (μm) is swimmer size) and consequently the motion of the swimmer (with average speed of...
Graphene/Cuo2nanoshuttles with controllable release of oxygen nanobubbles promoting interruption of bacterial respiration
, Article ACS Applied Materials and Interfaces ; Volume 12, Issue 32 , 2020 , Pages 35813-35825 ; Akhavan, O ; Madaah Hosseini, H. R ; Bakhshi, B ; Sharif University of Technology
American Chemical Society
2020
Abstract
An oxygen nanoshuttle based on a reduced graphene oxide/copper peroxide (rGO/CuO2) nanocomposite has been presented to deliver in situ oxygen nanobubbles (O2 NBs) for combating bacterial infections. In the presence of rGO, the solid source of oxygen (i.e., CuO2) was decomposed (in response to environmental conditions such as pH and temperature) into O2 NBs in a more controllable and long-lasting trend (from 60 to 144 h). In a neutral buffer, the O2 NBs experienced growth and collapse evolutions, creating a dynamic micro-nanoenvironment around the nanocomposite. In addition to effective battling against methicillin-resistant Staphylococcus aureus bacteria, the O2 NBs demonstrated superior...