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Data-Driven Based Methods to Design Anticancer Drugs to Target Kras
, M.Sc. Thesis Sharif University of Technology ; fattahi, Alireza (Supervisor) ; Rohban, Mohammad Hossein (Co-Supervisor)
Abstract
One of the goals of the current research is to investigate natural structures to inhibit Ras proteins that belong to the family of guanosine triphosphatase proteins. For example, one of the common mutations is Kras mutations, which are seen exclusively in pancreatic ductal adenocarcinoma. Changes in Kras protein expression are observed in 30 percent of lung cancer cases. Kras mutations occur in 35-45 percent of colon cancers, leading to drug resistance. Our work method in this research is that we collect a dataset of natural compounds for the target protein. Then, the binding energies of these structures with the receptor protein are calculated through Autodoc Vina. After that, using deep...
Natural compounds for skin tissue engineering by electrospinning of nylon-Beta vulgaris
, Article ASAIO Journal ; Volume 64, Issue 2 , 2018 , Pages 261-269 ; 10582916 (ISSN) ; Mahmoudifard, M ; Kehtari, M ; Babaie, A ; Hamedi, S ; Mirzaei, S ; Soleimani, M ; Hosseinzadeh, S ; Sharif University of Technology
Lippincott Williams and Wilkins
2018
Abstract
Natural compounds containing polysaccharide ingredients have been employed as candidates for treatment of skin tissue. Herein, for the first time, electrospinning setup was proposed to fabricate an efficient composite nanofibrous structure of Beta vulgaris (obtained from Beet [Chenopodiaceae or Amaranthaceae]) belonged to polysaccharides and an elastic polymer named nylon 66 for skin tissue engineering. Both prepared scaffolds including noncomposite and composite types were studied by Scanning electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, mechanical assay, and contact angle. Scanning electron microscope examinations have approved the uniform and homogeneous...