Loading...
Search for:
nephron
0.005 seconds
Simulation of Urine Concentrating Mechanism in Rat Kidney Inner Medulla
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor)
Abstract
Physicians use charts that are prepared by experiments on animals or humans to prescribe drug dosage for patients. This method requires much more time by the Ministry of Health to approve new drugs to be used in health-care centers. Furthermore،we have no sight on how a specific drug is going to be diffuse in our body. In order to predict the distribution of a drug or any minerals in the kidney we need to model it. The first step would be modeling the important species that influence the urine concentrating mechanism. Due to the complications in modeling that mechanism especially in the inner medulla zone، we hadn’t solid information regarding that area. It is about half a century that...
Modeling of Renal Autoregulation Systems
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor) ; Firoozbakhsh, Keikhosrow (Supervisor)
Abstract
The mathematical analysis of the kidney has always been considered due to its complex performance. It’s about two decades that mathematicians work on the mathematical modeling of this tissue. Since Glomerular filtration of blood in the kidney has been regarded by physiologists for many years, they can access only to the qualitative data. Mathematicians can solve this problem by numerical modeling. In this research, an engineering model is presented for the analysis of this capillary network by investigating in the different scientific fields such as, physiology, medicine, computer science and mathematics. There are two major renal autoregulatory mechanisms, the myogenic response and the...
Design and Fabrication of a Microfluidic Kidney Nephron-on-Chip Platform
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor) ; Hajilouy Benisi, Ali (Supervisor) ; Moghadas, Hajar (Co-Supervisor)
Abstract
In this manuscript, we designed and fabricated a novel integrated microfluidic Kidney Nephron-On-Chip. This chip is able to culture cell monolayers under various fluid shear stresses and divert osmotic pressure gradients while imposing four different concentrations of an injected drug on cells. The multi-layer platform consisting of two bubble-trappers to eliminate all unwanted bubbles from the system, a concentration gradient generator to generate four different concentrations of the injected drug, and a membrane-based cell culture chamber caple of providing renal cells with their in-vivo condition. Using colorimetric techniques, the bubble trapper ability was quantified at flow rates up to...
Three-dimensional simulation of urine concentrating mechanism in a functional unit of rat outer medulla. I. Model structure and base case results
, Article Mathematical Biosciences ; Vol. 258 , 2014 , pp. 44-56 ; ISSN: 00255564 ; Saidi, M. S ; Saadatmand, M ; Banazadeh, M. H ; Firoozabadi, B ; Sharif University of Technology
Abstract
The urine formation and excretion system have long been of interest for mathematicians and physiologists to elucidate the obscurities within the process happens in renal tissue. In this study, a novel three-dimensional approach is utilized for modeling the urine concentrating mechanism in rat renal outer medulla which is essentially focused on demonstrating the significance of tubule's architecture revealed in anatomic studies and physiological literature. Since nephrons and vasculatures work interdependently through a highly structured arrangement in outer medulla which is dominated by vascular bundles, a detailed functional unit is proposed based on this specific configuration....
3D simulation of solutes concentration in urinary concentration mechanism in rat renal medulla
, Article Mathematical Biosciences ; Volume 308 , 2019 , Pages 59-69 ; 00255564 (ISSN) ; Abdekhodaie, M. J ; Farhadi, F ; Shafiee, M. A ; Sharif University of Technology
Elsevier Inc
2019
Abstract
In this work, a mathematical model was developed to simulate the urinary concentration mechanism. A 3-D geometry was derived based on the detail physiological pictures of rat kidney. The approximate region of each tubule was obtained from the volume distribution of structures based on Walter Pfaller's monograph and Layton's region-based model. Mass and momentum balances were applied to solve for the change in solutes concentration and osmolality. The osmolality of short and long descending nephrons at the end of the outer medulla was obtained to be 530 mOsmol/kgH2O and 802 mOsmol/kgH2O, respectively, which were in acceptable agreement with experimental data. The fluid osmolality of the short...