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Directional migration and differentiation of neural stem cells within three-dimensional microenvironments, Article Integrative Biology (United Kingdom) ; Volume 7, Issue 3 , Jan , 2015 , Pages 335-344 ; 17579694 (ISSN) ; Heibatollahi, M ; Mofrad, M. R. K ; Sharif University of Technology
Royal Society of Chemistry 2015
Harnessing neural stem cells to repair neuronal damage is a promising potential treatment for neuronal diseases. To enable future therapeutic efficacy, the survival, proliferation, migration and differentiation of neural stem/progenitor cells (NPCs) should be accurately studied and optimized in in vitro platforms before transplanting these cells into the body for treatment purposes. Such studies can determine the appropriate quantities of the biochemical and biomechanical factors needed to control and optimize NPC behavior in vivo. In this study, NPCs were cultured within a microfluidic device while being encapsulated within the collagen matrix. The migration and differentiation of NPCs were...