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nitroalkene
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Synthesis of Bromonitroalkenes and their Applications as Electrophile in the Reaction with Indoles
, M.Sc. Thesis Sharif University of Technology ; Mahmoodi Hashemi, Mohammad (Supervisor) ; Ziyaei Halimehjani, Azim (Co-Advisor)
Abstract
In this work Nitroolefins were made by aromatic aldehydes consisting of electron withdrawing and electron donor groups. Afterward β-Bromo-β-nitrostyrenes were produced from interaction between nitroolefins and brom, at suitable temperature. After providing ingredients, micheal reaction (Friedel-crafts Pseudo-alkylation) between nitroolefins and various nucleophiles such as indoles was investigated. Finally desired micheal products were achived with high efficiency
Efficient Friedel-crafts alkylation of indoles and pyrrole with enones and nitroalkene in water
, Article Organic and Biomolecular Chemistry ; 2006, Volume 4, Issue 23, Pages 4275-4277 ; Arynasab, F ; Saidi, M. R ; Sharif University of Technology
Abstract
An operationally simple and entirely green protocol for heteropoly acid catalyst conjugate addition of indoles and pyrrole to unsaturated carbonyl compounds and nitro-alkene in water was investigated. It is important that the products arising from 1,2-addition were not observed under the reaction conditions. Pyrroles also readily underwent Michael addition at Α-positions under the same reaction conditions. Indole and many of its derivatives are present in many substances commonly found in nature. Micheal addition reactions are performed in organic solvents with the reactions in water are relatively scarce. The Michael addition between indole and methyl vinyl ketone in the presence of...
Efficient Friedel-crafts alkylation of indoles and pyrrole with enones and nitroalkene in water
, Article Organic and Biomolecular Chemistry ; Volume 4, Issue 23 , 2006 , Pages 4275-4277 ; 14770520 (ISSN) ; Arynasab, F ; Saidi, M. R ; Sharif University of Technology
2006
Abstract
An operationally simple and entirely green protocol for heteropoly acid catalyst conjugate addition of indoles and pyrrole to unsaturated carbonyl compounds and nitro-alkene in water was investigated. It is important that the products arising from 1,2-addition were not observed under the reaction conditions. Pyrroles also readily underwent Michael addition at Α-positions under the same reaction conditions. Indole and many of its derivatives are present in many substances commonly found in nature. Micheal addition reactions are performed in organic solvents with the reactions in water are relatively scarce. The Michael addition between indole and methyl vinyl ketone in the presence of...