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Expression analysis of Wnt signaling pathway related lncRNAs in periodontitis: A pilot case-control study
, Article Human Gene ; Volume 33 , 2022 ; 27730441 (ISSN) ; Dashti, S ; Gholami, L ; Badrlou, E ; Sadeghpour, S ; Hussen, B. M ; Hidayat, H. J ; Nazer, N ; Shadnoush, M ; Sayad, A ; Arefian, N ; Sharif University of Technology
Elsevier B.V
2022
Abstract
LncRNAs are involved in the modulation of several signaling pathways which have a crucial effect in the differentiation of periodontal ligament cells and the induction of cementum regeneration. Autophagy and Wnt signaling are two important pathways with a wide range of interrelationships associated with periodontitis. We chose four lncRNAs based on their potential interaction with these two pathways. We examined the expression of FOXD2-AS1, NNT-AS1, GAS8-AS1, and CCAT1 lncRNAs in tissues and blood specimens of patients with periodontitis and unaffected controls using qRT-PCR. Expression amounts of FOXD2-AS1 were lower in blood of cases compared with controls (relative expression (RE) = 0.08,...