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nonsteroidal-anti-inflammatory-drugs
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Fabrication of Porous Electrospun Fibe on Biocompatible Polymers such as Polycaprolactone (Pcl) and Thrs Based eir Application in Sample Preparation
, M.Sc. Thesis Sharif University of Technology ; Bagheri, Habib (Supervisor)
Abstract
The aim of this study was to develop a method to determine the trace residual amounts of nonsteroidal anti-inflammatory drugs in meat-related samples and to study the effect of different cooking methods and storage conditions of meat before cooking as an effective factor on the fate of these drugs. To proceed this goal, a nanocomposite was prepared from polycaprolactone nanofiber/silica mesopores as green sorbent by electrospinning. The synthesized nanocomposite was implemented for micro-solid phase extraction of the desired drugs in conjunction with high performance liquid chromatography. Polycaprolactone, due to its excellent physical properties, availability, biodegradability,...
Porous eco–friendly fibers for on–line micro solid–phase extraction of nonsteroidal anti–inflammatory drugs from urine and plasma samples
, Article Journal of Chromatography A ; Volume 1574 , 2018 , Pages 18-26 ; 00219673 (ISSN) ; Behkami, S ; Bagheri, H ; Sharif University of Technology
Elsevier B.V
2018
Abstract
In this study, cellulose acetate (CA) fibers were prepared using different solvent systems in electrospinning. The recorded scanning electron microscopy micrographs indicated that the morphology of the prepared fibers is closely associated with the type of electrospinning solvents. The prepared CA fibers were used as an extractive phase for on–line micro–solid phase extraction (μ-SPE) of nonsteroidal–inflammatory drugs (NSAIDs) in biological samples pursued by HPLC–UV determination. Work conducted on this research ascertained that the use of dichloromethane:acetone (3:1, v/v) solvent system in the CA dissolution for electrospinning, leads to the formation of porous ribbon–like fibers and...