Sharif Digital Repository

Background and objective: One of the important applications of non-invasive respiration monitoring using ECG signal is the detection of obstructive sleep apnea (OSA). ECG-derived respiratory (EDR) signals, contribute to useful information about apnea occurrence. In this paper, two EDR extraction methods are proposed, and their application in automatic OSA detection using single-lead ECG is investigated. Methods: EDR signals are extracted based on new respiration-related features in ECG beats morphology, such as ECG variance (EDRVar) and phase space reconstruction area (EDRPSR). After evaluating the EDRs by comparing them to a reference respiratory signal, they are used in an automatic OSA... 

Problem statement: Modeling Human cardiovascular system was always an important issue from long past because by doing such modeling, investigation in cardiovascular system and its abnormities would be simpler. One of the most effective ways to do such modeling is using lumped method (Electrical analogy). Approach: Lumped method was used for simulating a complete model in this approach. A 36-vessel model was chosen to make equivalent circuit of lumped method from it. This complicated circuit includes equivalent segment for arteries, pulmonary, atrium, left and right ventricles. Furthermore, in this complex circuit some additional points were considered to improve this method. Some of the most... 

Let M be a complete n-dimensional Riemannian spin manifold, partitioned by q two-sided hypersurfaces which have a compact transverse intersection N and which in addition satisfy a certain coarse transversality condition. Let E be a Hermitean bundle on M with connection. We define a coarse multi-partitioned index of the spin Dirac operator on M twisted by E. Our main result is the computation of this multi-partitioned index as the Fredholm index of the Dirac operator on the compact manifold N, twisted by the restriction of E to N. We establish the following main application: if the scalar curvature of M is bounded below by a positive constant everywhere (or even if this happens only on one of... 

False alarms ratios of up to 86% in Intensive Care Units (ICU) decrease quality of care, impacting both clinical staff and patients through slowing off response time and noise tribulation. We present a novel algorithm to predict heart arrhythmias in ICUs. We focus on five life-threatening arrhythmias: Asystole, Extreme Bradycardia, Extreme Tachycardia, Ventricular Tachycardia, and Ventricular Fibrillation. The algorithm is based on novel features using only 12 seconds of one ECG channel to predict the arrhythmias. Our new feature sets include different SQI and physiological features and the features used in obstructive sleep apnoea detection. We also proposed a new morphological... 

Lumped method (Electrical analogy) is a quick and easy way to model human cardiovascular system. In this paper Lumped method is used for simulating a complete model. It describes a 36-vessel model and cardiac system of human body with details that could show hydrodynamic parameters of cardiovascular system. Also this paper includes modeling of pulmonary, atrium, left and right ventricles with their equivalent circuits. Exact modeling of right and left ventricles pressure with division of ascending aorta into 27 segments increases the accuracy of our simulation. In this paper we show that a calculated pressure for aorta from our complex circuit is near to measured pressure by using advanced... 

The effects of insulated and isothermal thin baffles on pseudosteady-state natural convection within spherical containers were studied computationally. The computations are based on an iterative, finite-volume numerical procedure using primitive dependent variables. Natural convection effect is modeled via the Boussinesq approximation. Parametric studies were performed for a Prandtl number of 0.7. For Rayleigh numbers of 104, 105, 106, and 107, baffles with three lengths positioned at five different locations were investigated (120 cases). The fluid that is heated adjacent to the sphere rises replacing the colder fluid, which sinks downward through the stratified stable thermal layer. For... 

The respiratory system is a vital organ system which makes breathing and gas exchange possible for human's body. The loss of functionality in this system is due to either genetical problems or environmental issues like pollution or toxic gases which in many cases is inevitable. These circumstances may cause different respiratory diseases which may not be curable presently but their side effects can be partly controlled by careful and timely analysis improving the quality of patient's life. So, an appropriate device for conducting different analysis can be effective for people who suffer from respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, occupational lung... 

Biomechanical forces and hemodynamic factors influence the blood flow and the endothelial cells (ECs) morphology. These factors behave differently beyond the coronary artery stenosis. In the present study, unsteady blood flow in the left coronary artery (LCA) and its atherosclerotic bifurcating vessels, left anterior descending (LAD) and left circumflex (LCX) arteries, were numerically simulated to investigate the risk of plaque length development and secondary plaque formation in the post-stenotic areas. Using fluid–structure interaction (FSI) model, compliance of arterial wall and vessel curvature variations due to cardiac motion were considered. The arteries included plaques at the... 

Biomechanical forces and hemodynamic factors influence the blood flow and the endothelial cells (ECs) morphology. These factors behave differently beyond the coronary artery stenosis. In the present study, unsteady blood flow in the left coronary artery (LCA) and its atherosclerotic bifurcating vessels, left anterior descending (LAD) and left circumflex (LCX) arteries, were numerically simulated to investigate the risk of plaque length development and secondary plaque formation in the post-stenotic areas. Using fluid–structure interaction (FSI) model, compliance of arterial wall and vessel curvature variations due to cardiac motion were considered. The arteries included plaques at the... 

Background and Objective: Blood flow variation during cardiac cycle is the main mechanism of atherosclerotic development which is dependent on. Methods: The present work mainly tends to investigate stenosis effect in dynamic curvature of coronary artery. This paper presents numerical investigations on wall shear stress profiles in three-dimensional pulsatile flow through curved stenotic coronary arteries for both static and dynamic model. In order to do so, three-dimensional models related to the curved arteries with two degrees of stenosis (30% and 50%). Results: Lower amount of wall shear stress is found near the inner wall of artery distal to the plaque region (stenosis) and in both... 

The primary source of surgical site infection is the deposition of flakes released from the exposed skin of surgical staff or the patient on the exposed surgical wound. In this study, a computational model for simulating air ow and thermal conditions in an operating room is developed, and transport and deposition of particulate contaminants near the wound are analyzed. The results show the formation of a thermal plume over the wound tissue, which is typically at a higher temperature than the surrounding. The thermal plume protects the wound from the deposition of contaminants. In addition, the computational model predicts an optimum value for the inlet air velocity that is mainly maintaining... 

Objective. Sleep apnea is a serious respiratory disorder, which is associated with increased risk factors for cardiovascular disease. Many studies in recent years have been focused on automatic detection of sleep apnea from polysomnography (PSG) recordings, however, detection of subtle respiratory events named Respiratory Event Related Arousals (RERAs) that do not meet the criteria for apnea or hypopnea is still challenging. The objective of this study was to develop automatic detection of sleep apnea based on Hidden Markov Models (HMMs) which are probabilistic models with the ability to learn different dynamics of the real time-series such as clinical recordings. Approach. In this study, a... 

Atherosclerosis is a major cause of coronary artery disease leading to morbidity and mortality worldwide. Currently, coronary angiography is considered to be the most accurate technique to diagnose coronary artery disease (CAD). However, this technique is an invasive and expensive procedure with risks of serious complications. Since the symptoms of CAD are not noticed until advanced stages of the disease, early and effective diagnosis of CAD is considered a pertinent measure. In this paper, a non-invasive optical signal, the finger photoplethysmogram (PPG) obtained before and after reactive hyperemia is investigated to discriminate between subjects with different CAD conditions. To this end,... 

Purpose: Cardiac multimodal image fusion can offer an image with various types of information in a single image. Many coronary stenosis, which are anatomically clear, are not functionally significant. The treatment of such kind of stenosis can cause irreversible effects on the patient. Thus, choosing the best treatment planning depend on anatomical and functional information is very beneficial. Methods: An algorithm for the fusion of coronary computed tomography angiography (CCTA) as an anatomical and transthoracic echocardiography (TTE) as a functional modality is presented. CCTA and TTE are temporally registered using manifold learning. A pattern search optimization algorithm, using...