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online-micro–solid-phase-extraction–high-performance-liquid-chromatography
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Preparation of amine–modified lignin and its applicability toward online micro–solid phase extraction of valsartan and losartan in urine samples
, Article Journal of Chromatography A ; Volume 1643 , 2021 ; 00219673 (ISSN) ; Zeinali, S ; Bagheri, H ; Sharif University of Technology
Elsevier B.V
2021
Abstract
In the present work, with the focus on an environmentally–friendly approach, some gels were prepared by synthesizing amine–modified lignin, extracted from sugarcane bagasse, and further esterification and subsequent freeze–drying. These lignin–based gels were implemented as extractive phases in an online micro–solid phase extraction (μSPE) setup in conjunction with high performance liquid chromatography (HPLC) with UV detector. The developed method was used for analytical determination of valsartan and losartan in urine samples. To study the effect of the functionalization process, the efficiency of the unmodified lignin and the functionalized lignin were compared both in the absence and the...