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organ-on-chip
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Skin diseases modeling using combined tissue engineering and microfluidic technologies
, Article Advanced Healthcare Materials ; Volume 5, Issue 19 , 2016 , Pages 2459-2480 ; 21922640 (ISSN) ; Heidary Araghi, B ; Beydaghi, V ; Geraili, A ; Moradi, F ; Jafari, P ; Janmaleki, M ; Valente, K. P ; Akbari, M ; Sanati Nezhad, A ; Sharif University of Technology
Wiley-VCH Verlag
Abstract
In recent years, both tissue engineering and microfluidics have significantly contributed in engineering of in vitro skin substitutes to test the penetration of chemicals or to replace damaged skins. Organ-on-chip platforms have been recently inspired by the integration of microfluidics and biomaterials in order to develop physiologically relevant disease models. However, the application of organ-on-chip on the development of skin disease models is still limited and needs to be further developed. The impact of tissue engineering, biomaterials and microfluidic platforms on the development of skin grafts and biomimetic in vitro skin models is reviewed. The integration of tissue engineering and...
Numerical Simulation of Organ on Chip Systems
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor) ; Sani, Mehdi ($item.subfieldsMap.e)
Abstract
Discovering new medicines and generally medical researches, are time consuming and expensive. But recent achievements in cell culturing methods and micro and nano-engineering techniques have enabled the researchers to investigate new medicines in a lesser time and price. Huh et al. successfully fabricated the lung on chip device. This device is consisted of three chambers. The middle chamber is separated in two equal parts and side chambers were considered in order to apply normal breathing. Periodic deformation was needed to apply the natural condition of cultured cells by expansion and contraction. Numerical simulation was needed to investigate the properties of flow in this kind of...
A Dynamic Mesh Computational Fluid Dynamics Model of Lung on a Chip
, M.Sc. Thesis Sharif University of Technology ; Sani, Mehdi (Supervisor) ; Khayyat, Ali Akbar (Supervisor)
Abstract
Recent investigations on organs-on-chip devices have broadened our insight into the functions of the organs and their responses to pharmaceuticals. Studies on improving the efficiency of these chips are on going. The development of chips for growing various organs and possibly their possible interconnection are other hot topics in this field. This research is an attempt to simulate a Lung-on-a-Chip (LOC) device using Ansys Fluent software. Currently a new experimental technique for setting up a lung-on-a-chip device has been made public (Zamprogno et.al.ˏ̎ Second-generation lung-on-a-Chip with an array of stretchable alveoli made with a biological memvrane ̎ ˏComm. Biologyˏ2021ˏ4:168.). This...
Simulation, Design and fabrication of Kidney on a Chip
, Ph.D. Dissertation Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor) ; Firoozabadi, Bahar (Supervisor) ; Mosadegh, Bobak ($item.subfieldsMap.e)
Abstract
Renal diseases and consequently kidney failure is one of the important death factors around the world in recent years. It causes hundreds of thousands die every year and is in progress. Researchers believe that increasing chemical and nonchemical materials density in the blood which is the air pollution, use of tobacco and other parameters cause renal cells misfunction in urine filtration and regulation of blood pressure. The goal of this work is design and fabrication of a microfluidic device which provides different cell types to be cultured and imposed pressure. To do this, a high throughput microfluidic device is needed to mimic kidney biologically. Having such a device helps to analyze...
Design and Fabrication of a Microfluidic Device to Study the Growth of Breast Cancer Cell
, M.Sc. Thesis Sharif University of Technology ; Vosughi, Manuchehr (Supervisor) ; Shamloo, Amir (Supervisor) ; Naserifar, Naser (Supervisor)
Abstract
for decades Cancer has been one of the major causes of death universally. Though extensive efforts in developing new anticancer therapies, they face failures in clinical trials and curing the sick owing to time consuming and expensive preclinical models with poor predictions of drug responses in human. To address this challenge it is crucial to develop preclinical models mimicking the main aspects of a tumor that can provide effective prediction of therapeutic responses. Tumor on chip technology has appeared as a promising approach for providing effective cancer models and reliable preclinical predictions. In this project, collagen was first extracted as the main constituent of the tumor...
Investigating the Effect of Lymph Vessel Applying in Organ-On-A-Chip System to Improve the Biomimicry-Inspired Design Strategy
, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheila (Supervisor) ; Mashayekhan, Shohreh (Co-Supervisor)
Abstract
In the last decade, the application of organ-on-chip systems to investigate the effectiveness and side effects of various drugs, modele diseases for different tissues has become noticed a lot because these systems are a promising approach to eliminate animal tests and clinical studies on different people. Current conventional methods for drug testing are expensive, time-consuming, and sometimes unreliable. Various organ-on-a-chip systems have been fabricated in order to mimic the conditions of different native tissues in the human body, but only the blood vessel has been considered in most of them while besides blood vessels, as a source to nourish cells, there are lymph vessels as a sink in...
Microfluidic-based multi-organ platforms for drug discovery
, Article Micromachines ; Volume 7, Issue 9 , 2016 ; 2072666X (ISSN) ; Khadem Mohtaram, N ; Pezeshgi Modarres, H ; Mohammadi, M. H ; Geraili, A ; Jafari, P ; Akbari, M ; Sanati Nezhad, A ; Sharif University of Technology
MDPI AG
Abstract
Development of predictive multi-organ models before implementing costly clinical trials is central for screening the toxicity, efficacy, and side effects of new therapeutic agents. Despite significant efforts that have been recently made to develop biomimetic in vitro tissue models, the clinical application of such platforms is still far from reality. Recent advances in physiologically-based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling, micro- and nanotechnology, and in silico modeling have enabled single- and multi-organ platforms for investigation of new chemical agents and tissue-tissue interactions. This review provides an overview of the principles of designing...
Controlling differentiation of stem cells for developing personalized organ-on-chip platforms
, Article Advanced Healthcare Materials ; Volume 7, Issue 2 , 2018 ; 21922640 (ISSN) ; Jafari, P ; Sheikh Hassani, M ; Heidary Araghi, B ; Mohammadi, M. H ; Ghafari, A. M ; Hassanpour Tamrin, S ; Pezeshgi Modarres, H ; Rezaei Kolahchi, A ; Ahadian, S ; Sanati Nezhad, A ; Sharif University of Technology
Wiley-VCH Verlag
2018
Abstract
Organ-on-chip (OOC) platforms have attracted attentions of pharmaceutical companies as powerful tools for screening of existing drugs and development of new drug candidates. OOCs have primarily used human cell lines or primary cells to develop biomimetic tissue models. However, the ability of human stem cells in unlimited self-renewal and differentiation into multiple lineages has made them attractive for OOCs. The microfluidic technology has enabled precise control of stem cell differentiation using soluble factors, biophysical cues, and electromagnetic signals. This study discusses different tissue- and organ-on-chip platforms (i.e., skin, brain, blood–brain barrier, bone marrow, heart,...
In Silico Lung-on-a-Chip Simulation for Disease Modeling and Drug Delivery Purposes
, M.Sc. Thesis Sharif University of Technology ; Bastani, Dariush (Supervisor) ; Mashayekhan, Shohreh (Supervisor) ; Moghadas, Hajar (Co-Supervisor)
Abstract
Organ-on-chip microfluidic devices create a three-dimensional and dynamic model that allows researchers to model diseases and test different drug candidates. In this regard, using a lung-on-a-chip microfluidic device, Covid-19 disease was numerically modeled. Initially, the distribution of oxygen concentration in the blood and respiratory membrane in the healthy state; when the respiratory membrane is the only barrier between air and blood; was found and observed that in this case, the length that the blood had to travel to reach full saturation was the same in the alveolar capillaries and the lung-on-a-chip microdevice. Then, to simulate the different phases of the disease, the formation of...