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osteoconductive
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Evaluation of bioactivity and biocompatibility of silk fibroin/TiO2 nanocomposite
, Article Journal of Medical and Biological Engineering ; Volume 38, Issue 1 , February , 2018 , Pages 99-105 ; 16090985 (ISSN) ; Madaah Hosseini, H. R ; Taromi, N ; Arasteh, S ; Kazemnejad, S ; Samadi Kuchaksaraei, A ; Sharif University of Technology
Springer Berlin Heidelberg
2018
Abstract
Biodegradable polymer/bioceramic nanocomposites are osteoconductive and can accelerate healing of bone tissue. In this research, silk fibroin (SF)/titanium dioxide (TiO2) nanocomposites were synthesized using different concentrations of TiO2 nanoparticles (0, 5, 10, 15 and 20 wt%). The SF/TiO2 nanocomposites were studied in terms of bioactivity and biocompatibility. The in vitro assessment of osteoblasts compatibility indicated that SF inclusion rendered nanocomposite biocompatible whereas presence of TiO2 nanoparticles allowed the cells to adhere and grow on nanocomposite surface and enhanced the bioactivity of the composite. © 2017, Taiwanese Society of Biomedical Engineering
Biological evaluation of a novel tissue engineering scaffold of Layered Double Hydroxides (LDHs)
, Article Key Engineering Materials, 6 November 2011 through 9 November 2011 ; Volume 493-494 , November , 2012 , Pages 902-908 ; 10139826 (ISSN) ; 9783037852552 (ISBN) ; Solati Hashjin, M ; Shokrgozar, M. A ; Bonakdar, S ; Ganji, Y ; Mirjordavi, N ; Ghavimi, S. A ; Khashayar, P ; Sharif University of Technology
2012
Abstract
Bone Tissue Engineering (BTE) composed of three main parts: scaffold, cells and signaling factors. Several materials and composites are suggested as a scaffold for BTE. Biocompatibility is one of the most important property of a BTE scaffold. In this work synthesis of a novel nanocomposite including layered double hydroxides (LDH) and gelatin is carried out and its biological properties were studied. The co-precipitation (pH=11) method was used to prepare the LDH powder, using calcium nitrate, Magesium nitrate and aluminum nitrate salts as starting materials. The resulted precipitates were dried. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron...
In vitro study of hydroxyapatite/polycaprolactone (HA/PCL) nanocomposite synthesized by an in situ sol-gel process
, Article Materials Science and Engineering C ; Volume 33, Issue 1 , 2013 , Pages 390-396 ; 09284931 (ISSN) ; Mohammadi, M. R ; Sharif University of Technology
2013
Abstract
Hydroxyapatite (HA) is the most substantial mineral constituent of a bone which has been extensively used in medicine as implantable materials, owing to its good biocompatibility, bioactivity high osteoconductive, and/or osteoinductive properties. Nevertheless, its mechanical property is not utmost appropriate for a bone substitution. Therefore, a composite consist of HA and a biodegradable polymer is usually prepared to generate an apt bone scaffold. In the present work polycaprolactone (PCL), a newly remarkable biocompatible and biodegradable polymer, was employed as a matrix and hydroxyapatite nanoparticles were used as a reinforcement element of the composite. HA/PCL nanocomposites were...