Sharif Digital Repository

Acute lymphoblastic leukemia is one of the most common hematologic malignancies among children, caused by uncontrolled growth of leukocytes. Since the main hallmarks of the disease is not specific, a considerable number of patients have been being misdiagnosed. Early diagnosis of the disease is usually made by morphological investigation of leukocytes under microscope. In light of the facts that decrease in cytoplasm-to-nucleus ratio is one of the main indicators of cancerous cells, and an accurate segmentation phase will lead to extraction of representative features, segmentation step is acknowledged as being crucial in design of a computer aided diagnosis (CAD). Previous researches have... 

Herniation in the lumbar area is one of the most common diseases which results in lower back pain (LBP) causing discomfort and inconvenience in the patients' daily lives. A computer aided diagnosis (CAD) system can be of immense benefit as it generates diagnostic results within a short time while increasing precision of diagnosis and eliminating human errors. We have proposed a new method for automatic diagnosis of lumbar disc herniation based on clinical MRI data. We use T2-W sagittal and myelograph images. The presented method has been applied on 30 clinical cases, each containing 7 discs (210 lumbar discs) for the herniation diagnosis. We employ Otsu thresholding method to extract the...