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    The argus-II retinal prosthesis implantation; from the global to local successful experience

    , Article Frontiers in Neuroscience ; Volume 12, Issue SEP , 2018 ; 16624548 (ISSN) Farvardin, M ; Afarid, M ; Attarzadeh, A ; Johari, M. K ; Mehryar, M ; Nowroozzadeh, M. H ; Rahat, F ; Peyvandi, H ; Farvardin, R ; Nami, M ; Sharif University of Technology
    Abstract
    Over the past few years, visual prostheses (namely, Argus II retinal implant) and gene therapy have obtained FDA approval in treating blindness resulting from retinitis pigmentosa. Compared to gene therapy; Argus II is less costly with a demonstrated favorable outcome, though the vision is yet artificial. To obtain better results, expectation counseling and preoperative retinal assessment are critical. The global experience with Argus II has enrolled no more than 300 cases so far. The first Argus II retinal prosthesis in Iran was successfully implanted in Shiraz (October 2017). To date, Argus II artificial retina is implanted in four patients in Iran. Beside successful surgery and... 

    An expert system for selecting wart treatment method

    , Article Computers in Biology and Medicine ; Volume 81 , 2017 , Pages 167-175 ; 00104825 (ISSN) Khozeimeh, F ; Alizadehsani, R ; Roshanzamir, M ; Khosravi, A ; Layegh, P ; Nahavandi, S ; Sharif University of Technology
    Elsevier Ltd  2017
    Abstract
    As benign tumors, warts are made through the mediation of Human Papillomavirus (HPV) and may grow on all parts of body, especially hands and feet. There are several treatment methods for this illness. However, none of them can heal all patients. Consequently, physicians are looking for more effective and customized treatments for each patient. They are endeavoring to discover which treatments have better impacts on a particular patient. The aim of this study is to identify the appropriate treatment for two common types of warts (plantar and common) and to predict the responses of two of the best methods (immunotherapy and cryotherapy) to the treatment. As an original work, the study was... 

    A systematic review of the effect of foot orthoses and shoe characteristics on balance in healthy older subjects

    , Article Prosthetics and Orthotics International ; Volume 40, Issue 2 , 2016 , Pages 170-181 ; 03093646 (ISSN) Aboutorabi, A ; Bahramizadeh, M ; Arazpour, M ; Fadayevatan, R ; Farahmand, F ; Curran, S ; Hutchins, S. W ; Sharif University of Technology
    SAGE Publications Inc  2016
    Abstract
    Background: Foot orthoses are used to optimize lower extremity function and can improve postural stability by enhancing the afferent somatosensory feedback available to the central nervous system. Objective: The aim of this review was to evaluate the effect of foot orthoses on balance control in older subjects. Study design: Systematic review. Methods: The search strategy was based on the Population Intervention Comparison Outcome method. A search was performed in PubMed, Science Direct, Google Scholar, and ISI Web of Knowledge databases by using selected keywords. A total of 22 articles were selected for final evaluation. Results: The results demonstrated that older people should be advised... 

    Comparison of spinal stability following motor control and general exercises in nonspecific chronic low back pain patients

    , Article Clinical Biomechanics ; Volume 48 , 2017 , Pages 42-48 ; 02680033 (ISSN) Shamsi, M ; Sarrafzadeh, J ; Jamshidi, A ; Arjmand, N ; Ghezelbash, F ; Sharif University of Technology
    Abstract
    Background Motor control exercise was claimed to improve spinal stability in patients with chronic non-specific back pain, but to investigate the effectiveness of this exercise, other outcome measures have been used rather than spinal stability itself. The aim of our study is to assess motor control exercise effects on spinal stability using a biomechanical model. Methods Fifty-one patients were assigned to either motor control or general exercises. Before and after trainings, participants were tested for spinal stability at seven isometric tasks. Electromyography signals were recorded from ten superficial muscles, and a hybrid EMG-driven musculoskeletal model estimated spinal stability... 

    In vitro biological outcome of laser application for modification or processing of titanium dental implants

    , Article Lasers in Medical Science ; Volume 32, Issue 5 , 2017 , Pages 1197-1206 ; 02688921 (ISSN) Hindy, A ; Farahmand, F ; Tabatabaei, F. S ; Sharif University of Technology
    Abstract
    There are numerous functions for laser in modern implant dentistry including surface treatment, surface coating, and implant manufacturing. As laser application may potentially improve osseointegration of dental implants, we systematically reviewed the literature for in vitro biological responses to laser-modified or processed titanium dental implants. The literature was searched in PubMed, ISI Web, and Scopus, using keywords “titanium dental implants,” “laser,” “biocompatibility,” and their synonyms. After screening the 136 references obtained, 28 articles met the inclusion criteria. We found that Nd:YAG laser was the most commonly used lasers in the treatment or processing of titanium... 

    Assessment and comparison of اomogeneity and conformity indexes in step-and-shoot and compensator-based intensity modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3D CRT) in prostate cancer

    , Article Journal of Medical Signals and Sensors ; Volume 7, Issue 2 , 2017 , Pages 102-107 ; 22287477 (ISSN) Salimi, M ; Shirani Tak Abi, K ; Nedaie, H. A ; Hassani, H ; Gharaati, H ; Samei, M ; Shahi, R ; Zarei, H ; Sharif University of Technology
    Abstract
    Intensity modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3D CRT) are two treatment modalities in prostate cancer, which provide acceptable dose distribution in tumor region with sparing the surrounding normal tissues. IMRT is based on inverse planning optimization; in which, intensity of beams is modified by using multileaf collimators and also compensators with optimum shapes in step and shoot (SAS) and compensator-based method, respectively. In the recent study, some important parameters were compared in two IMRT and 3D CRT methods. Prescribed dose was 80 Gy for both IMRT procedures and 70 Gy for 3D CRT. Treatment plans of 15 prostate cancer... 

    Effects of cognitive load on the amount and temporal structure of postural sway variability in stroke survivors

    , Article Experimental Brain Research ; Volume 236, Issue 1 , 2018 , Pages 285-296 ; 00144819 (ISSN) Mehdizadeh, H ; Khalaf, K ; Ghomashchi, H ; Taghizadeh, G ; Ebrahimi, I ; Taghavi Azar Sharabiani, P ; Mousavi, S. J ; Parnianpour, M ; Sharif University of Technology
    Springer Verlag  2018
    Abstract
    This study aimed to investigate the variability in postural sway patterns during quiet standing in stroke survivors. The postural sway was measured in 19 stroke survivors, as well as 19 healthy demographically matched participants, at 3 levels of postural difficulty (rigid surface with closed and open eyes, and foam surface with closed eyes), and 3 levels of cognitive difficulty (without a cognitive task, easy and difficult cognitive tasks). Both linear analyses (the amount of postural sway variability, including the standard deviation of the COP velocity in both the anteroposterior (AP) and mediolateral (ML) directions), as well as non-linear analyses [the temporal structure of the COP... 

    Effects of lumbosacral orthosis on dynamical structure of center of pressure fluctuations in patients with non-specific chronic low back pain: A randomized controlled trial

    , Article Journal of Bodywork and Movement Therapies ; Volume 23, Issue 4 , 2019 , Pages 930-936 ; 13608592 (ISSN) Azadinia, F ; Ebrahimi Takamjani, I ; Kamyab, M ; Asgari, M ; Parnianpour, M ; Sharif University of Technology
    Churchill Livingstone  2019
    Abstract
    Background: A few clinical trials have examined the effect of treatment interventions on postural control in patients with chronic low back pain, all of which have exclusively evaluated postural stability using traditional linear measures of postural sway. However, postural control improvement cannot be determined by exclusively relying on linear measurements, because these parameters provide no information on underlying motor control mechanisms. Objective: This study aimed to compare the effect of using lumbosacral orthoses (LSO) together with routine physical therapy, compared to routine physical therapy alone on postural control, using nonlinear analysis techniques. Methods: Forty-four... 

    Cultural adaptation and validation of the persian version of the arthritis impact measurement scales 2-short form in patients with osteoarthritis of the knee

    , Article Disability and Rehabilitation ; Volume 31, Issue 25 , 2009 , Pages 2081-2087 ; 09638288 (ISSN) Askary Ashtiani, A. R ; Mousavi, J ; Montazeri, A ; Shamsollahi, S ; Parnianpour, M ; Sharif University of Technology
    2009
    Abstract
    Purpose.To translate and validate the Persian version of the Arthritis Measurement Scales 2-Short Form (AIMS2-SF) in patients with osteoarthritis (OA) of the knee. Method.The translation and cultural adaptation of the original questionnaire was carried out in accordance with published guidelines. One hundred and fourteen consecutive Persian-speaking patients with OA of the knee were participated in this study. The Short Form Health Survey (SF-36) and visual analogue scales (VAS) for pain and joint stiffness were used to test convergent validity of the Persian AIMS2-SF. In addition, 35 randomly selected patients were asked to complete the questionnaire 3 days later for the second time.... 

    Translation and validation of the Persian version of the Arthritis Impact Measurement Scales 2-Short Form (AIMS2-SF) in patients with rheumatoid arthritis

    , Article Clinical Rheumatology ; Volume 28, Issue 5 , 2009 , Pages 521-527 ; 07703198 (ISSN) Askary Ashtiani, A. R ; Mousavi, S. J ; Parnianpour, M ; Montazeri, A ; Sharif University of Technology
    2009
    Abstract
    Cultural adaptation and validation of the Persian version of the Arthritis Measurement Scales 2-Short Form (AIMS2-SF). The translation and cultural adaptation of the original questionnaire was carried out in accordance with published guidelines. Three hundred and fifty consecutive Persian-speaking patients with rheumatoid arthritis (RA) were asked to complete the AIMS2-SF, the Short Form Health Survey (SF-36), and four visual analog scales (VAS) for pain, joint stiffness, and patient's and physician's global assessment to test convergent validity. In addition, 90 randomly selected patients were asked to complete the questionnaire 48 h later for the second time. Moderate to high correlation... 

    Lower extremity kinematic analysis in male athletes with unilateral anterior cruciate reconstruction in a jump-landing task and its association with return to sport criteria

    , Article BMC Musculoskeletal Disorders ; Volume 20, Issue 1 , 2019 ; 14712474 (ISSN) Norouzi, S ; Esfandiarpour, F ; Mehdizadeh, S ; Yousefzadeh, N. K ; Parnianpour, M ; Sharif University of Technology
    BioMed Central Ltd  2019
    Abstract
    Background: Return to sport (RTS) criteria are widely being used to identify anterior cruciate ligament reconstructed (ACLR) athletes ready to return to sportive activity and reduce risk of ACL re-injury. However, studies show a high rate of ACL re-injury in athletes who passed RTS criteria. This indicates that the current RTS criteria might not be sufficient to determine return to sport time in ACLR athletes. Previous studies have reported a close association between altered lower limb kinematics and ACL re-injury. However, it is not clear how lower extremity kinematics differs between ACLR athletes who passed the RTS-criteria and who failed. This study compared lower extremity kinematics... 

    A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial

    , Article European Journal of Clinical Nutrition ; Volume 73, Issue 9 , 2019 , Pages 1224-1235 ; 09543007 (ISSN) Chashmniam, S ; Mirhafez, S. R ; Dehabeh, M ; Hariri, M ; Azimi Nezhad, M ; Nobakht M. Gh, B. F ; Sharif University of Technology
    Nature Publishing Group  2019
    Abstract
    Background/Objectives: Curcumin, a natural polyphenol compound in the spice turmeric, has been found to have potent anti-oxidative and anti-inflammatory activity. Curcumin may treat non-alcoholic fatty liver disease (NAFLD) through its beneficial effects on biomarkers of oxidative stress (OS) and inflammation, which are considered as two feature of this disease. However, the effects of curcumin on NAFLD have been remained poorly understood. This investigation evaluated the effects of administrating curcumin on metabolic status in NAFLD patients. Subjects/Methods: Fifty-eight NAFLD patients participated in a randomized, double-blind, placebo-controlled parallel design of study. The subjects... 

    Five insights from the Global Burden of Disease Study 2019

    , Article The Lancet ; Volume 396, Issue 10258 , 2020 , Pages 1135-1159 Abbafati, C ; Machado, D. B ; Cislaghi, B ; Salman, O. M ; Karanikolos, M ; McKee, M ; Abbas, K. M ; Brady, O. J ; Larson, H. J ; Trias-Llimós, S ; Cummins, S ; Langan, S.M ; Sartorius, B ; Hafiz, A ; Jenabi, E ; Mohammad Gholi Mezerji, N ; Borzouei, S ; Azarian, G ; Khazaei, S ; Abbasi, M ; Asghari, B ; Masoumi, S ; Komaki, H ; Taherkhani, A ; Adabi, M ; Abbasifard, M ; Bazmandegan, G ; Kamiab, Z ; Vakilian, A ; Anjomshoa, M ; Mokari, A ; Sabour, S ; Shahbaz, M ; Saeedi, R ; Ahmadieh, H ; Yousefinezhadi, T ; Haj-Mirzaian, A ; Nikbakhsh, R ; Safi, S ; Asgari, S ; Irvani, S.N ; Jahanmehr, N ; Ramezanzadeh, K ; Abbasi-Kangevari, M ; Khayamzadeh, M ; Abbastabar, H ; Shirkoohi, R ; Fazlzadeh, M ; Janjani, H ; Hosseini, M ; Mansournia, M ; Tohidinik, H ; Bakhtiari, A ; Fazaeli, A ; Mousavi, S ; Hasanzadeh, A ; Nabavizadeh, B ; Malekzadeh, R ; Hashemian, M ; Pourshams, A ; Salimzadeh, H ; Sepanlou, S. G ; Afarideh, M ; Esteghamati, A ; Esteghamati, S ; Ghajar, A ; Heidari, B ; Rezaei, N ; Mohamadi, E ; Rahimi-Movaghar, A ; Rahim, F ; Eskandarieh, S ; Sahraian, M ; Mohebi, F ; Aminorroaya, A ; Ebrahimi, H ; Farzadfar, F ; Mohajer, B ; Pishgar, F ; Saeedi Moghaddam, S ; Shabani, M ; Zarafshan, H ; Abolhassani, H ; Hafezi Nejad, N ; Heidari Soureshjani, R ; Abdollahi, M ; Farahmand, M ; Salamati, P ; Mehrabi Nasab, E ; Tajdini, M ; Aghamir, S ; Mirzaei, R ; Dibaji Forooshani, Z ; Khater, M. M ; Abd-Allah, F ; Abdelalim, A ; Abualhasan, A ; El-Jaafary, S. I ; Hassan, A ; Elsharkawy, A ; Khater, A. M ; Elhabashy, H. R ; Salem, M. R. R ; Salem, H ; Sadeghi, M ; Jafarinia, M ; Amini-Rarani, M ; Mohammadifard, N ; Sarrafzadegan, N ; Abdollahpour, I ; Sarveazad, A ; Tehrani Banihashemi, A ; Yoosefi Lebni, J ; Manafi, N ; Pazoki Toroudi, H ; Dorostkar, F ; Alipour, V ; Sheikhtaheri, A ; Arabloo, J ; Azari, S ; Ghashghaee, A ; Rezapour, A ; Naserbakht, M ; Kabir, A ; Mehri, F ; Yousefifard, M ; Asadi Aliabadi, M ; Babaee, E ; Eshrati, B ; Goharinezhad, S ; Moradi Lakeh, M ; Abedi, P ; Rashedi, V ; Kumar, V ; Elgendy, I. Y ; Basu, S ; Park, J ; Pereira, A ; Norheim, O. F ; Eagan, A. W ; Cahill, L. E ; Sheikh, A ; Abushouk, A. I ; Kraemer, M. U. G ; Thakur, B ; Bärnighausen, T. W ; Shrime, M. G ; Abedi, A ; Doshi, C. P ; Abegaz, K. H ; Geberemariyam, B. S ; Aynalem, Y. A ; Shiferaw, W. S ; Abosetugn, A. E ; Aboyans, V ; Abrams, E. M ; Gitimoghaddam, M ; Kissoon, N ; Stubbs, J. L ; Brauer, M ; Iyamu, I. O ; Kopec, J. A ; Pourmalek, F ; Ribeiro, A. P ; Malta, D. C ; Gomez, R. S ; Abreu, L. G ; Abrigo, M. R. M ; Almulhim, A. M ; Dahlawi, S. M. A ; Pottoo, F. H ; Menezes, R. G ; Alanzi, T. M ; Alumran, A. K ; Abu Haimed, A. K ; Madadin, M ; Alanezi, F. M ; Abu-Gharbieh, E ; Saddik, B ; Abu Raddad, L. J ; Samy, A. M ; El Nahas, N ; Shalash, A. S ; Nabhan, A. F ; Kamath, A. M ; Kassebaum, N. J ; Aravkin, A. Y ; Kochhar, S ; Sorensen, R. J. D ; Afshin, A ; Burkart, K ; Cromwell, E. A ; Dandona, L ; Dharmaratne, S. D ; Gakidou, E ; Hay, S. I ; Kyu, H. H ; Lopez, A. D ; Lozano, R ; Misganaw, A. T ; Mokdad, A. H ; Naghavi, M ; Pigott, D. M ; Reiner Jr, R. C ; Roth, G. A ; Stanaway, J. D ; Vollset, S ; Vos, T ; Wang, H ; Lim, S. S ; Murray, C. J. L ; Kalani, R ; Ikuta, K. S ; Cho, D. Y ; Kneib, C. J ; Crowe, C. S ; Massenburg, B. B ; Morrison, S. D ; Acebedo, A ; Adelson, J. D ; Agesa, K. M ; Alam, T ; Albertson, S. B ; Anderson, J. A ; Antony, C. M ; Ashbaugh, C ; Assmus, M ; Azhar, G ; Balassyano, S ; Bannick, M. S ; Barthelemy, C. M ; Bender, R. G ; Bennitt, F. B ; Bertolacci, G. J ; Biehl, M. H ; Bisignano, C ; Boon Dooley, A. S ; Briant, P. S ; Bryazka, D ; Bumgarner, B. R ; Callender, C. S ; Cao, J ; Castle, C. D ; Castro, E ; Causey, K ; Cercy, K. M ; Chalek, J ; Charlson, F. J ; Cohen, A. J ; Comfort, H ; Compton, K ; Croneberger, A. J ; Cruz, J. A ; Cunningham, M ; Dandona, R ; Dangel, W. J ; Dean, F. E ; DeCleene, N. K ; Deen, A ; Degenhardt, L ; Dingels, Z. V ; Dippenaar, I. N ; Dirac, M. A ; Dolgert, A. J ; Emmons Bell, S ; Estep, K ; Farag, T ; Feigin, V. L ; Feldman, R ; Ferrara, G ; Ferrari, A. J ; Fitzgerald, R ; Force, L. M ; Fox, J. T ; Frank, T. D ; Fu, W ; Fukutaki, K ; Fuller, J. E ; Fullman, N ; Galles, N. C ; Gardner, W. M ; Gershberg Hayoon, A ; Goren, E ; Gorman, T. M ; Gottlich, H. C ; Guo, G ; Haddock, B ; Hagins, H ; Haile, L. M ; Hamilton, E. B ; Han, C ; Han, H ; Harvey, J. D ; Henny, K ; Henrikson, H. J ; Henry, N. J ; Herbert, M. E ; Hsiao, T ; Huynh, C. K ; Iannucci, V. C ; Ippolito, H ; Irvine, C. M. S ; Jafari, H ; Jahagirdar, D ; James, S. L ; Johnson, C. O ; Johnson, S.C ; Keller, C ; Kemmer, L ; Kendrick, P. J ; Knight, M ; Kocarnik, J. M ; Krohn, K. J ; Larson, S. L ; Lau, K. M ; Ledesma, J. R ; Leever, A. T ; LeGrand, K. E ; Lescinsky, H ; Lin, C ; Liu, H ; Liu, Z ; Lo, J ; Lu, A ; Ma, J ; Maddison, E. R ; Manguerra, H ; Marks, A ; Martopullo, I ; Mastrogiacomo, C. I ; May, E. A ; Mooney, M. D ; Mosser, J. F ; Mullany, E. C ; Mumford, J ; Munro, S. B ; Nandakumar, V ; Nguyen, J ; Nguyen, M ; Nichols, E ; Nixon, M. R ; Odell, C. M ; Ong, K. L ; Orji, A. U ; Ostroff, S. M ; Pasovic, M ; Paulson, K. R ; Pease, S. A ; Pennini, A ; Pierce, M ; Pilz, T. M ; Pletcher, M ; Rao, P. C ; Razo, C ; Redford, S. B ; Reinig, N ; Reitsma, M. B ; Rhinehart, P ; Robalik, T ; Roberts, S ; Roberts, N. L. S ; Rolfe, S ; Sbarra, A. N ; Schaeffer, L. E ; Shackelford, K. A ; Shadid, J ; Sharara, F ; Shaw, D. H ; Sheena, B. S ; Simpson, K. E ; Smith, A ; Spencer, C. N ; Spurlock, E. E ; Stark, B. A ; Steiner, C ; Steuben, K. M ; Sylte, D. O ; Tang, M ; Taylor, H. J ; Terrason, S ; Thomson, A. M ; Torre, A. E ; Travillian, R ; Troeger, C. E ; Vongpradith, A ; Walters, M. K ; Wang, J ; Watson, A ; Watson, S ; Whisnant, J. L ; Whiteford, H. A ; Wiens, K. E ; Wilner, L. B ; Wilson, S ; Wool, E. E ; Wozniak, S. S ; Wu, J ; Wulf Hanson, S ; Wunrow, H ; Xu, R ; Sharif University of Technology
    Lancet Publishing Group  2020
    Abstract
    The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD... 

    Magnitude, symmetry and attenuation of upper body accelerations during walking in women: The role of age, fall history and walking surface

    , Article Maturitas ; Volume 139 , 2020 , Pages 49-56 Soleimanifar, M ; Mazaheri, M ; van Schooten, K. S ; Asgari, M ; Mosallanezhad, Z ; Salavati, M ; Sedaghat Nejad, E ; Parnianpour, M ; Sharif University of Technology
    Elsevier Ireland Ltd  2020
    Abstract
    Objectives: The present experiment examined the role of age and fall history in upper body accelerations when walking on an even and on an uneven surface. Study design: An observational cross-sectional study. Main outcome measures: The magnitude (root mean square [RMS]), symmetry (harmonic ratio) and attenuation (attenuation coefficient) of upper body accelerations were quantified as primary outcomes; gait spatiotemporal parameters were measured as secondary outcomes. Methods: Twenty young adults (mean ± SD age: 29.00 ± 4.51 yrs), 20 older non-fallers (66.60 ± 5.43 yrs) and 20 older fallers (68.55 ± 4.86 yrs) walked on an even and on an uneven surface, while wearing four accelerometers... 

    Oral administration of lithium chloride ameliorate spinal cord injury-induced hyperalgesia in male rats

    , Article PharmaNutrition ; Volume 21 , 2022 ; 22134344 (ISSN) Rahimi, G ; Mirsadeghi, S ; Rahmani, S ; Izadi, A ; Ghodsi, Z ; Ghodsi, S. M ; Rahimi Movaghar, V ; Kiani, S ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    Background: Numerous studies have described the neuroprotective effect of lithium in spinal cord injury in addition to its ameliorative impact on pain sensation. In the present study, we aim to examine the efficacy of 85 mg/kg as well as 50 mg/kg dosage of the lithium chloride (LiCl) through oral consumption in spinal cord injured rats and their effect on gene expression of three candidate genes, corresponding to the hyper-sensitization. Methods: Adult Wistar (male) rats were divided into four experimental groups: control; oral administration of LiCl with 85 mg/kg and 50 mg/kg dosage; and 10 % sucrose receiver as the vehicle. BBB and heat plantar tests were performed weekly throughout four... 

    Role of Thigh Muscle Changes in Knee Osteoarthritis Outcomes: Osteoarthritis Initiative Data

    , Article Radiology ; Volume 305, Issue 1 , 2022 , Pages 169-178 ; 00338419 (ISSN) Mohajer, B ; Dolatshahi, M ; Moradi, K ; Najafzadeh, N ; Eng, J ; Zikria, B ; Wan, M ; Cao, X ; Roemer, F. W ; Guermazi, A ; Demehri, S ; Sharif University of Technology
    Radiological Society of North America Inc  2022
    Abstract
    Background: Longitudinal data on the association of quantitative thigh muscle MRI markers with knee osteoarthritis (KOA) outcomes are scarce. These associations are of clinical importance, with potential use for thigh muscle–directed disease-modifying interventions. Purpose: To measure KOA-associated longitudinal changes in MRI-derived muscle cross-sectional area (CSA) and adipose tissue and their association with downstream symptom worsening and knee replacement (KR). Materials and Methods: In a secondary analysis of the Osteoarthritis Initiative multicenter prospective cohort (February 2004 through October 2015), knees of participants with available good-quality thigh MRI scans at baseline...