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Effect of cysteine oxidation in SARS-CoV-2 receptor-binding domain on its interaction with two cell receptors: Insights from atomistic simulations
, Article Journal of Chemical Information and Modeling ; Volume 62, Issue 1 , 2022 , Pages 129-141 ; 15499596 (ISSN) ; Privat Maldonado, A ; Yusupov, M ; Rahnama, S ; Bogaerts, A ; Ejtehadi, M. R ; Sharif University of Technology
American Chemical Society
2022
Abstract
Binding of the SARS-CoV-2 S-glycoprotein to cell receptors is vital for the entry of the virus into cells and subsequent infection. ACE2 is the main cell receptor for SARS-CoV-2, which can attach to the C-terminal receptor-binding domain (RBD) of the SARS-CoV-2 S-glycoprotein. The GRP78 receptor plays an anchoring role, which attaches to the RBD and increases the chance of other RBDs binding to ACE2. Although high levels of reactive oxygen and nitrogen species (RONS) are produced during viral infections, it is not clear how they affect the RBD structure and its binding to ACE2 and GRP78. In this research, we apply molecular dynamics simulations to study the effect of oxidation of the highly...
Role of carrier characteristics affecting microbial density and population in enhanced nitrogen and phosphorus removal from wastewater
, Article Journal of Environmental Management ; Volume 302 , 2022 ; 03014797 (ISSN) ; Raie, M ; Borghei, S. M ; Dewil, R ; Appels, L ; Sharif University of Technology
Academic Press
2022
Abstract
This research aims to improve simultaneous nitrification-denitrification and phosphorus removal (SNDPR) using novel carriers and to demonstrate the effect of carrier characteristics on nutrient removal in a biofilm reactor. For this purpose, biofilms enriched with both polyphosphate-accumulating organisms (PAOs) and nitrifiers were cultivated in two parallel sequencing batch reactors containing conventional moving bed bioreactor carriers (MBBR) and a novel type of carriers (carbon-based moving carriers (CBMC)). The new carriers were produced based on recycled waste materials via a chemical-thermal process and their specific surface area were 10.4 times higher than typical MBBR carriers of...
Bottom-up synthesis of nitrogen and oxygen co-decorated carbon quantum dots with enhanced DNA plasmid expression
, Article Colloids and Surfaces B: Biointerfaces ; Volume 184 , 2019 ; 09277765 (ISSN) ; Khezri, J ; Esfandiari, S ; Mahdavi, H ; Karkhane, A. A ; Rahighi, R ; Heidarimoghadam, R ; Tayebi, L ; Hashemi, E ; Farmany, A ; Sharif University of Technology
Elsevier B.V
2019
Abstract
In this paper, a bottom-up hydrothermal route is reported for the synthesis of oxygen and nitrogen co-decorated carbon quantum dots (CQDs) using ammonium hydrogen citrate (AHC) as a single precursor. DLS data approved the formation of 4.0 nm (average size) CQDs. XRD pattern shows the interlayer spacing (002) of 3.5 Å for CQDs, which is exactly the same as that of crystalline graphite. XPS and FTIR spectra verified the formation of oxygen and nitrogen functional groups on the CQDs surface. Co-decorated carboxyl, hydroxyl and amine groups on the CQDs surfaces make them as promising polyelectrolyte for gene delivery. Toxicity assay showed a survival rate of 70% under different incubation times...