Sharif Digital Repository

Dielectrophoresis (DEP) is an electrokinetic phenomenon which is used for manipulating micro- and nanoparticles in micron-sized devices with high sensitivity. In recent years, electrode-based DEP by patterning narrow oblique electrodes in microchannels has been used for particle manipulation. In this theoretic study, a microchannel with triangular electrodes is presented and a detailed comparison with oblique electrodes is made. For each shape, the behavior of particles is compared for three different configurations of applied voltages. Electric field, resultant DEP force, and particle trajectories for configurations are computed by means of Rayan native code. The separation efficiency of... 

Problems regarding simulation of field emitter array (FEA) electron guns are discussed. A simple method is proposed to significantly reduce computational requirements such as computation power, system memory, and time of FEA electron gun simulation and modeling. The method can be applied to any numerical solver regardless of its meshing technique. In order to extract field emission parameter from any experimental cathode I-V curve, a partly numerical algorithm, which uses the presented truncation method at the heart of its solver, is proposed. The proposed method and algorithm are applied to a number of examples, including a double-gated FEA problem, and its effectiveness in terms of error... 

Particle dispersion in the vortex flow has been one of the most interesting subjects in recent years. Bidirectional vortex flow field is an industrial sample of the rotating flow which is used to obtain advantages of better mixing and combustion. In this work penetration and dispersion quality of the particles which are entering from various positions on the vortex engine walls have been numerically predicted. Head side, end side, and sidewall are considered as the entering positions. The particle has been assumed to be a rigid sphere. Initial velocity, diameter, and density of entering the particles are assumed to be known. If the particle length scale is considered not to be comparable... 

Recently, electrode-based Dielectrophoresis (eDEP) has been used for particle manipulation by means of triangular electrodes. In this theoretical and numerical study, a microchannel with quarter-of-ellipse electrodes is presented and a detailed comparison with triangular electrodes is provided. Electric field, resultant DEP force, and particle trajectories for each microchannel are evaluated by means of COMSOL Multiphysics 4.4. Afterwards, focusing and separation efficiencies of the systems are assessed and compared. Finally, separation efficiency of our proposed model for live and dead cells is compared with that of our previous model published in the literature [1]. It is demonstrated that... 

In this paper, the structure of a wall jet deflected by a baffle along with the trajectory of particles has been studied. This baffle is used to produce a stable deflected surface jet, thereby deflecting the high-velocity supercritical stream away from the bed to the surface. An elliptic relaxation turbulence model (v2̄ - f model) has been used to simulate this submerged flow. During the last few years, the v2̄ - f turbulence model has become increasingly popular due to its ability to account for near-wall damping without use of damping functions. In addition, it has been proven that the v2̄ - f model is superior to other RANS methods in many fluid flows where complex flow features are... 

Circulating tumor cells (CTCs) isolation from a blood sample plays an important role in cancer diagnosis and treatment. Microfluidics offers a great potential for cancer cell separation from the blood. Among the microfluidic-based methods for CTC separation, the inertial method as a passive method and magnetic method as an active method are two efficient well-established methods. Here, we investigated the combination of these two methods to separate CTCs from a blood sample in a single chip. Firstly, numerical simulations were performed to analyze the fluid flow within the proposed channel, and the particle trajectories within the inertial cell separation unit were investigated to... 

The separation of cancer cells from a heterogeneous biological sample such as blood plays a vital role in cancer study and future treatments. In this paper, we designed and investigated two microfluidic devices for cancer cell separation, including a serpentine inertial device and an integrated inertial-magnetophoretic device. Firstly, numerical modeling was carried out to study the fluid flow, particles’ trajectories in the inertial device. Then the device was fabricated using soft photolithography and suspension of two types of microparticles with the size of 10 and 15 µm were injected into the microchannel separately to investigate the particles’ trajectories and focusing behavior at... 

The separation of cancer cells from a heterogeneous biological sample such as blood plays a vital role in cancer study and future treatments. In this paper, we designed and investigated two microfluidic devices for cancer cell separation, including a serpentine inertial device and an integrated inertial-magnetophoretic device. Firstly, numerical modeling was carried out to study the fluid flow, particles’ trajectories in the inertial device. Then the device was fabricated using soft photolithography and suspension of two types of microparticles with the size of 10 and 15 µm were injected into the microchannel separately to investigate the particles’ trajectories and focusing behavior at... 

This article presents a process of numerically predicting and experimentally verifying the dispersion quality and penetration level of fuel particles entering and moving in various directions relative to vortex engine walls. If the length scale of particles considered in this study is not comparable to the chamber length and, furthermore, the density is ignored, the effect of the particle on the flow field can be neglected and a one-way solution will be viable for the problem. The solutions in each case are carried out to estimate the particle trajectory and parameters affecting it. The governing equations are converted to a set of nonlinear, coupled, ordinary differential equations (ODEs)... 

In this paper, the structure of a wall jet deflected by a baffle along with the trajectory of particles has been studied. This baffle is used to produce a stable deflected surface jet, thereby deflecting the high-velocity supercritical stream away from the bed to the surface. An elliptic relaxation turbulence model (ν̄2-f model) has been used to simulate this submerged flow. In recent years, the ν̄2- f turbulence model has become increasingly popular due to its ability to account for near-wall damping without use of damping functions. In addition, it has been proven that the ν̄2- f model is superior to other Reynolds-averaged Navier-Stokes (RANS) methods in many flows where complex flow... 

Aerosol measurement is used in a variety of fields such as nanotechnology, materials science, pollution monitoring, air quality measurements, combustion and engine exhaust analysis, inhalation toxicology, and medical studies. One of the most prevalent methods for aerosol measurement is to use electrical mobility. An electrical mobility spectrometer (EMS) is used to measure aerosol particles size distribution ranging from 10-1000 nanometers, under the influence of an electric field. The accuracy of this distribution is influenced by flow conditions, the geometry of the EMS, the electric field, and the number of electrode rings. In this work, a multi-channel EMS is studied using computational... 

Particle dispersion in the vortex flow has been one of the most interesting subjects in recent years. Bidirectional vortex flow field is an industrial sample of rotating flow which is used to obtain advantages of better mixing and combustion. In this work penetration and dispersion quality of particles which are entering from various positions on the vortex engine walls have been numerically predicted. Head side, end side, and sidewall are considered as the entering positions. The particle has been assumed to be a rigid sphere. Initial velocity, diameter, and density of entering particles are assumed to be known. If the particle length scale is considered not to be comparable with the... 

In this research particle trajectory in a bidirectional vortex flow has been numerically predicted and the results experimentally validated. Scale analyses of forces show their order of magnitudes and give a criterion to recognize the order of magnitude of exerting forces on the particle. The particle has been assumed to be a rigid sphere. Initial velocity, diameter, density, and position of entering particle are assumed to be known. If the particle length scale is considered not to be comparable with the chamber length and if particle number density is low, then influence of particle on the flow field is negligible and a one-way solution is applicable. The governing equation is converted to... 

Experimental acoustic cell separation methods have been widely used to perform separation for different types of blood cells. However, numerical simulation of acoustic cell separation has not gained enough attention and needs further investigation since by using numerical methods, it is possible to optimize different parameters involved in the design of an acoustic device and calculate particle trajectories in a simple and low cost manner before spending time and effort for fabricating these devices. In this study, we present a comprehensive finite element-based simulation of acoustic separation of platelets, red blood cells and white blood cells, using standing surface acoustic waves...