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pathogenic-bacterium
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Smart chip for visual detection of bacteria using the electrochromic properties of polyaniline
, Article Analytical Chemistry ; Volume 91, Issue 23 , 2019 , Pages 14960-14966 ; 00032700 (ISSN) ; Farahmand Nejad, M. A ; Parolo, C ; Shahrokhian, S ; Merkoci, A ; Sharif University of Technology
American Chemical Society
2019
Abstract
Finding fast and reliable ways to detect pathogenic bacteria is crucial for addressing serious public health issues in clinical, environmental, and food settings. Here, we present a novel assay based on the conversion of an electrochemical signal into a more convenient optical readout for the visual detection of Escherichia coli. Electropolymerizing polyaniline (PANI) on an indium tin oxide screen-printed electrode (ITO SPE), we achieved not only the desired electrochromic behavior but also a convenient way to modify the electrode surface with antibodies (taking advantage of the many amine groups of PANI). Applying a constant potential to the PANI-modified ITO SPE induces a change in their...
Optimization and characterization of tannic acid loaded niosomes for enhanced antibacterial and anti-biofilm activities
, Article Advanced Powder Technology ; 2020 ; Akbarzadeh, I ; Nourouzian, D ; Mirzaie, A ; Bakhshandeh, H ; Sharif University of Technology
Elsevier B.V
2020
Abstract
The purpose of this study was to prepare and characterize an optimized system of tannic acid-loaded niosomes as a potential carrier for antibacterial and anti-biofilm delivery. The niosomal formulation was optimized using response surface methodology (RSM). The effects of the molar ratio of surfactant to cholesterol, drug concentration, and molar ratio of Span 60 to Tween 60 on particle size and drug entrapment efficiency of the niosomal nanocarrier were studied. The optimized nanoparticles were characterized in terms of the morphology, in vitro release profile, and antibacterial properties. Moreover, Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC)...