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    Epidemiology and patho-physiological studies in trypanosoma evansi infected camels and buffaloes in Pakistan

    , Article Pakistan Journal of Agricultural Sciences ; Volume 58, Issue 2 , 2021 , Pages 711-718 ; 05529034 (ISSN) Hussain, R ; Mehmood, K ; Abbas, R. Z ; Khan, I ; Siddique, A. B ; Masood, S ; Qadir, M.S ; Ishaq, H. M ; Akram, R ; Ghori, M.T ; Khan, A ; Tayyib, M ; Sharif University of Technology
    University of Agriculture  2021
    Abstract
    This study describes some epidemiological and patho-physiological aspects of Trypanosoma evansi (causative agent of “surra”) infection in camels (n=255) and Nili Ravi buffaloes (n=233). Clinical ailments like fever, shivering, edema of pads and urticarial swelling were observed in infected animals. Overall prevalence of T. evansi infection in buffaloes was 9.01 and 15.12% based on blood smear examination and PCR, respectively, while in camels, the prevalence was 10.58 and 15.29% based on smear examination and PCR, respectively. Results on epidemiological data did not indicate significant association of different factors of hosts with prevalence of T. evansi. Hematological parameters... 

    HEROHE Challenge: Predicting HER2 status in breast cancer from hematoxylin–eosin whole-slide imaging

    , Article Journal of Imaging ; Volume 8, Issue 8 , 2022 ; 2313433X (ISSN) Conde Sousa, E ; Vale, J ; Feng, M ; Xu, K ; Wang, Y ; Della Mea, V ; La Barbera, D ; Montahaei, E ; Baghshah, M ; Turzynski, A ; Gildenblat, J ; Klaiman, E ; Hong, Y ; Aresta, G ; Araújo, T ; Aguiar, P ; Eloy, C ; Polónia, A ; Sharif University of Technology
    MDPI  2022
    Abstract
    Breast cancer is the most common malignancy in women worldwide, and is responsible for more than half a million deaths each year. The appropriate therapy depends on the evaluation of the expression of various biomarkers, such as the human epidermal growth factor receptor 2 (HER2) transmembrane protein, through specialized techniques, such as immunohistochemistry or in situ hybridization. In this work, we present the HER2 on hematoxylin and eosin (HEROHE) challenge, a parallel event of the 16th European Congress on Digital Pathology, which aimed to predict the HER2 status in breast cancer based only on hematoxylin–eosin-stained tissue samples, thus avoiding specialized techniques. The... 

    Generalizability of trunk muscle EMG and spinal forces

    , Article IEEE Engineering in Medicine and Biology Magazine ; Volume 20, Issue 6 , 2001 , Pages 72-81 ; 07395175 (ISSN) Sparto, P. J ; Parnianpour, M ; Sharif University of Technology
    2001
    Abstract
    The generalizability of trunk muscle EMG and spinal loading estimates obtained from an EMG-assisted biomechanical model was assessed over three occasions and three repetitions. The greatest sources of variability consisted of the intersubject differences and the interaction between subject and occasion. The ID (reliability coefficient) was less for trunk muscle activity compared with estimates of anteroposterior shear force, compression force, and gain computed from the biomechanical model. In order to obtain an ID of 0.8, we recommend five testing occasions for submaximal EMG measurements and three testing occasions for biomechanical estimates. Reproducible estimates of maximal trunk... 

    A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth

    , Article Scientific Reports ; Volume 10, Issue 1 , 20 February , 2020 Nikmaneshi, M. R ; Firoozabadi, B ; Mozafari, A ; Munn, L. L ; Sharif University of Technology
    Nature Research  2020
    Abstract
    The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. Because in vivo experimental methods are unable to isolate or control individual factors of the TME and in vitro models often do not include all the contributing factors, some questions are best addressed with systems biology mathematical models. In this work, we present a new fully-coupled, agent-based, multi-scale mathematical model of tumor growth, angiogenesis and metabolism that includes important aspects of the TME spanning subcellular-, cellular- and tissue-level scales. The mathematical model is... 

    Role of endurance training in preventing pathological hypertrophy via large tumor suppressor (LATS) changes

    , Article Iranian Heart Journal ; Volume 20, Issue 3 , 2019 , Pages 52-59 ; 17357306 (ISSN) Tabrizi, A ; Soori, R ; Choobineh, S ; Gholipour, M ; Sharif University of Technology
    Iranian Heart Association  2019
    Abstract
    Background: One of the negative effects of cardiac sympathetic hyperactivity is pathologic hypertrophy. Recent studies have indicated that large tumor suppressor (LATS) is one of the molecules which play a critical role in cardiomyocyte apoptosis. Considering the preventive role of exercise training, we evaluated the effects of endurance training on LATS gene expression and its upstream pathway in the present study. Methods: Eighteen male Wistar rats were randomly divided into 2 groups: Endurance and control. Endurance training was performed for 8 weeks, 1 hour per day, and 6 days per week on the treadmill at a 15° inclination. Pathologic hypertrophy was induced with the injection of 3... 

    Parallel nonlinear analysis of weighted brain's gray and white matter images for Alzheimer's dementia diagnosis

    , Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference ; 2010 , Pages 5573-5576 ; 1557170X (ISSN) Razavian, S. M ; Torabi, M ; Kim, K ; Sharif University of Technology
    2010
    Abstract
    In this study, we are proposing a novel nonlinear classification approach to discriminate between Alzheimer's Disease (AD) and a control group using T1-weighted and T2-weighted Magnetic Resonance Images (MRI's) of brain. Since T1-weighted images and T2-weighted images have inherent physical differences, obviously each of them has its own particular medical data and hence, we extracted some specific features from each. Then the variations of the relevant eigenvalues of the extracted features were tracked to pick up the most informative ones. The final features were assigned to two parallel systems to be nonlinearly categorized. Considering the fact that AD defects the white and gray regions... 

    Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

    , Article Nature Medicine ; Volume 27, Issue 10 , 2021 , Pages 1761-1782 ; 10788956 (ISSN) Kinyoki, D ; Osgood-Zimmerman, A.E ; Bhattacharjee, N.V ; Schaeffer, L.E ; Lazzar-Atwood, A ; Lu, D ; Ewald, S.B ; Donkers, K.M ; Letourneau, I.D ; Collison, M ; Schipp, M.F ; Abajobir, A ; Abbasi, S ; Abbasi, N ; Abbasifard, M ; Abbasi-Kangevari, M ; Abbastabar, H ; Abd-Allah, F ; Abdelalim, A ; Abd-Elsalam, S.M ; Abdoli, A ; Abdollahpour, I ; Abedi, A ; Abolhassani, H ; Abraham, B ; Abreu, L.G ; Abrigo, M.R.M ; Abualhasan, A ; Abu-Gharbieh, E ; Abushouk, A.I ; Accrombessi, M.M.K ; Adabi, M ; Adebayo, O.M ; Adegbosin, A.E ; Adekanmbi, V ; Adetokunboh, O.O ; Adeyinka, D.A ; Adham, D ; Advani, S.M ; Agasthi, P ; Aghaali, M ; Ahmad, S ; Ahmad, T ; Ahmadi, K ; Ahmadi, S ; Ahmed, M.B ; Aichour, M.T.E ; Aji, B ; Akinyemi, O.O ; Aklilu, A ; Akunna, C.J ; Al-Aly, Z ; Alanzi, T.M ; Alcalde-Rabanal, J.E ; Alemu, B.W ; Alemu, A ; Alhassan, R.K ; Alif, S.M ; Alipour, V ; Alizade, H ; Aljunid, S.M ; Almasi-Hashiani, A ; Al-Mekhlafi, H.M ; Al-Raddadi, R.M ; Alvis-Guzman, N ; Amini, S ; Amiri, F ; Amugsi, D.A ; Anber, N.H ; Ancuceanu, R ; Andrei, T ; Anegago, M.T ; Anjomshoa, M ; Ansari, F ; Ansari-Moghaddam, A ; Anteneh, Z.A ; Antriyandarti, E ; Anvari, D ; Anwer, R ; Aqeel, M ; Arabloo, J ; Arab-Zozani, M ; Aremu, O ; Areri, H.A ; Artaman, A ; Arzani, A ; Asaad, M ; Asadi-Aliabadi, M ; Asadi-Pooya, A.A ; Asemahagn, M.A ; Asghari Jafarabadi, M ; Ashebir, M.M ; Ataro, Z ; Athari, S.M ; Athari, S.S ; Atout, M.M.W ; Ausloos, M ; Awoke, N ; Ayala Quintanilla, B.P ; Ayano, G ; Ayanore, M.A ; Aynalem, Y.A ; Ayza, M.A ; Azadmehr, A ; B, D ; Babalola, T.K ; Badawi, A ; Badiye, A.D ; Bahrami, M.A ; Bairwa, M ; Bakkannavar, S.M ; Banik, P.C ; Baraki, A.G ; Barboza, M.A ; Basaleem, H ; Basu, S ; Bayati, M ; Baye, B.A ; Bazmandegan, G ; Bedi, N ; Bekuma, T.T.T ; Bell, M. L ; Bensenor, I. M ; Berhe, K ; Berhe, A. K ; Berhie, K. A ; Bhandari, D ; Bhardwaj, N ; Bhardwaj, P ; Bhattacharyya, K ; Bhattarai, S ; Bhutta, Z. A ; Bijani, A ; Bikbov, B ; Biondi, A ; Birhanu, M ; Biswas, R. K ; Bockarie, M. J ; Bohlouli, S ; Bohluli, M ; Boloor, A ; Borzouei, S ; Bragazzi, N. L ; Braithwaite, D ; Brunoni, A. R ; Burugina Nagaraja, S ; Butt, Z. A ; Caetano dos Santos, F. L ; Cámera, L. A ; Car, J ; Cárdenas, R ; Carvalho, F ; Castaldelli-Maia, J.M ; Castañeda-Orjuela, C.A ; Castro, F ; Cevik, M ; Chanie, W.F ; Charan, J ; Chatterjee, S ; Chattu, V.K ; Chaturvedi, S ; Chen, S ; Chin, K.L ; Chowdhury, M.A.K ; Cook, A.J ; Costa, V.M ; Cromwell, E.A ; Dachew, B.A ; Dagne, H ; Dagnew, B ; Dahiru, T ; Dahlawi, S. M. A ; Dai, H ; Dai, H ; Dandona, L ; Dandona, R ; Daneshpajouhnejad, P ; Daoud, F ; Das, J.K ; Das Gupta, R ; Dash, A.P ; Dávila-Cervantes, C. A ; Davletov, K ; Deeba, F ; De Neve, J. W ; Denova Gutiérrez, E ; Deribe, K ; Desalew, A ; Dessie, G. A ; Dey, S ; Dhimal, M ; Dhungana, G. P ; Dianatinasab, M ; Diaz, D ; Dipeolu, I. O ; Djalalinia, S ; Do, H. T ; Dorostkar, F ; Doshmangir, L ; Duko, B ; Duraes, A. R ; Earl, L ; Edinur, H. A ; Efendi, F ; Elayedath, R ; Elema, T. B ; Elhabashy, H. R ; El-Jaafary, S. I ; El Sayed, I ; El Sayed Zaki, M ; Elsharkawy, A ; El-Sherbiny, Y. M ; El Tantawi, M ; Endalew, D. A ; Eshrati, B ; Eskandari, K ; Eskandarieh, S ; Fadhil, I ; Faraon, E. J. A ; Fareed, M ; Faris, P. S ; Farwati, M ; Farzadfar, F ; Fasanmi, A. O ; Fattahi, N ; Fauk, N. K ; Feigin, V. L ; Feleke, B. E ; Fereshtehnejad, S. M ; Fernandes, E ; Ferrara, P ; Foigt, N. A ; Fomenkov, A. A ; Foroutan, M ; Francis, J. M ; Franklin, R. C ; Freitas, M ; Fukumoto, T ; Gad, M. M ; Gaidhane, A. M ; Gayesa, R. T ; Geberemariyam, B. S ; Gebregiorgis, B. G ; Gebremariam, H ; Gebremariam, T. B. B ; Gebremeskel, L ; Gebremeskel, G. G ; Gebreslassie, A. A ; Geramo, Y. C. D ; Gesesew, H. A ; Gessner, B. D ; Getacher, L ; Ghadiri, K ; Ghaffarifar, F ; Ghafourifard, M ; Ghajarzadeh, M ; Ghamari, F ; Ghashghaee, A ; Ghith, N ; Gilani, S. A ; Gill, T. K ; Godinho, M. A ; Gona, P. N ; Grada, A ; Gubari, M. I. M ; Gudi, N ; Guido, D ; Guled, R. A ; Guo, Y ; Gupta, R ; Gupta, R ; Haj Mirzaian, A ; Hamadeh, R. R ; Handiso, D. W ; Hanif, A ; Hargono, A ; Hasaballah, A. I ; Hasan, M. M ; Hasan, S. S ; Hashemian, M ; Hashi, A ; Hassan, S ; Hassan, A ; Hassanipour, S ; Hassankhani, H ; Hayat, K ; Hegazy, M. I ; Heidari Soureshjani, R ; Henry, N. J ; Herteliu, C ; Heydarpour, F ; Heydarpour, S ; Hidru, H. D ; Hoang, C. L ; Holla, R ; Hon, J ; Hong, S. H ; Hoogar, P ; Hosseini, S. N ; Hosseinzadeh, M ; Hostiuc, M ; Hostiuc, S ; Hotez, P. J ; Househ, M ; Huda, T. M ; Huluko, D. H. H ; Hussain, S. A ; Hwang, B. F ; Ilesanmi, O. S ; Ilic, I. M ; Ilic, M. D ; Inbaraj, L.R ; Iqbal, U ; Islam, M.M ; Islam, S.M.S ; Iwu, C.J ; Iwu, C.C.D ; Jadidi-Niaragh, F ; Jahani, M.A ; Jain, V ; Jakovljevic, M ; Jalali, A ; Jalilian, F ; Janodia, M.D ; Javaheri, T ; Jha, R.P ; John, O ; Johnson, K.B ; Jonas, J.B ; Jonnagaddala, J ; Joseph, N ; Joshi, A ; Joukar, F ; Jozwiak, J.J ; Kabir, A ; Kabir, Z ; Kahlon, T ; Kalankesh, L.R ; Kalhor, R ; Kamath, A ; Kamiab, Z ; Kanchan, T ; Kapil, U ; Kapoor, N ; Karami Matin, B ; Karimi, S.E ; Kasa, A.S ; Kasahun, G.G ; Kassa, Z.Y ; Kassa, G.G ; Kassahun, G ; Kayode, G.A ; Kazemi Karyani, A ; Keflie, T.S ; Keiyoro, P.N ; Kelkay, B ; Keramati, M ; Ketema, D.B ; Khalid, N ; Khammarnia, M ; Khan, M.N ; Khan, M ; Khan, J ; Khatab, K ; Khater, A.M ; Khater, M.M ; Khoja, A.T ; Khubchandani, J ; Kianipour, N ; Kim, Y.-E ; Kim, Y.J ; Kimokoti, R.W ; Kisa, S ; Kisa, A ; Kolola, T ; Koolivand, A ; Kosen, S ; Koul, P. A ; Koyanagi, A ; Krishan, K ; Krishnamoorthy, V ; Kuate Defo, B ; Kugbey, N ; Kulkarni, V ; Kumar, G. A ; Kumar, N ; Kumar, P ; Kumar, M ; Kurmi, O. P ; Kusuma, D ; Lacey, B ; Lad, D. P ; Lal, D.K ; Lami, F. H ; Landires, I ; Larsson, A. O ; Lasrado, S ; Laurens, M. B ; La Vecchia, C ; Laxmaiah, A ; Sharif University of Technology
    Nature Research  2021
    Abstract
    Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Additionally, we provide subnational disparity analyses to provide a comprehensive overview of anemia prevalence inequalities within these countries and predict progress toward the World Health Organization’s Global Nutrition Target (WHO GNT) to reduce anemia by half by 2030. Our results... 

    Investigation of wall shear stress related factors in realistic carotid bifurcation geometries and different flow conditions

    , Article Scientia Iranica ; Volume 17, Issue 5 B , 2010 , Pages 358-366 ; 10263098 (ISSN) Jamalian Ardakani, S. S ; Jafarnejad, M ; Firoozabadi, B ; Saidi, M. S ; Sharif University of Technology
    Abstract
    Cardiovascular diseases are one of the major causes of death in the world; atherosclerosis being one aspect. Carotid bifurcation is one of the sites that are vulnerable to this disease. Wall Shear Stress (WSS) is known to be responsible for the process of atherogenesis. In this study, we have simulated the blood flow for Newtonian and non-Newtonian, steady and unsteady, flow conditions in three idealistic and five realistic geometries. A risk factor has been presented based on the results of wall shear stress and, then, a relation was found between geometrical features and the wall shear stress risk factor. Our main conclusions are: 1) The non-Newtonian behavior of blood elevates the value... 

    An ellipsoidal model for studying response of head impacts

    , Article Acta of Bioengineering and Biomechanics ; Volume 12, Issue 1 , 2010 , Pages 47-53 ; 1509409X (ISSN) Heydari, M ; Jani, S ; Sharif University of Technology
    2010
    Abstract
    The objective of this study was to propose a new analytical model for studying response of head impacts. Head is modeled by fluidfilled ellipsoidal shell of inconstant thickness impacted by a solid elastic sphere. Modeling the head as an ellipsoid is more realistic than modeling it as a sphere, the previous model existing in the literature [3]-[8]. In this model, the effect of Hertzian contact stiffness and local shell stiffness are combined to derive explicit equations for impact duration, the peak force transmitted to head, and the head injury criterion. One of the advantages of the model presented is sensitivity to the site of impact. A comparison between the present analytical results... 

    Unified model of brain tissue microstructure dynamically binds diffusion and osmosis with extracellular space geometry

    , Article Physical Review E - Statistical, Nonlinear, and Soft Matter Physics ; Volume 94, Issue 3 , 2016 ; 15393755 (ISSN) Yousefnezhad, M ; Fotouhi, M ; Vejdani, K ; Kamali Zare, P ; Sharif University of Technology
    American Physical Society  2016
    Abstract
    We present a universal model of brain tissue microstructure that dynamically links osmosis and diffusion with geometrical parameters of brain extracellular space (ECS). Our model robustly describes and predicts the nonlinear time dependency of tortuosity (λ=D/D∗) changes with very high precision in various media with uniform and nonuniform osmolarity distribution, as demonstrated by previously published experimental data (D = free diffusion coefficient, D∗ = effective diffusion coefficient). To construct this model, we first developed a multiscale technique for computationally effective modeling of osmolarity in the brain tissue. Osmolarity differences across cell membranes lead to changes... 

    The effect of lumbosacral orthosis on the thickness of deep trunk muscles using ultrasound imaging: a randomized controlled trial in patients with chronic low back pain

    , Article American Journal of Physical Medicine and Rehabilitation ; Volume 98, Issue 7 , 2019 , Pages 536-544 ; 08949115 (ISSN) Azadinia, F ; Takamjani, I. E ; Kamyab, M ; Kalbassi, G ; Sarrafzadeh, J ; Parnianpour, M ; Sharif University of Technology
    Lippincott Williams and Wilkins  2019
    Abstract
    Objective This study was conducted to evaluate the changes occurring in the thickness of deep trunk muscles, measured using ultrasound imaging, after 4 wks of lumbosacral orthosis use in conjunction with routine physical therapy. Design This parallel-group, randomized, controlled trial was conducted on 44 patients with nonspecific chronic low back pain, randomly allocated to the experimental and control groups. Both groups received eight sessions of physical therapy twice per week for 4 wks. The experimental group wore nonextensible lumbosacral orthosis, in addition to undergoing routine physical therapy. The thickness of the transversus abdominis, obliquus internus, and lumbar multifidus... 

    Biomechanical effects of lumbar fusion surgery on adjacent segments using musculoskeletal models of the intact, degenerated and fused spine

    , Article Scientific Reports ; Volume 11, Issue 1 , 2021 ; 20452322 (ISSN) Ebrahimkhani, M ; Arjmand, N ; Shirazi Adl, A ; Sharif University of Technology
    Nature Research  2021
    Abstract
    Adjacent segment disorders are prevalent in patients following a spinal fusion surgery. Postoperative alterations in the adjacent segment biomechanics play a role in the etiology of these conditions. While experimental approaches fail to directly quantify spinal loads, previous modeling studies have numerous shortcomings when simulating the complex structures of the spine and the pre/postoperative mechanobiology of the patient. The biomechanical effects of the L4–L5 fusion surgery on muscle forces and adjacent segment kinetics (compression, shear, and moment) were investigated using a validated musculoskeletal model. The model was driven by in vivo kinematics for both preoperative (intact or... 

    Transplantation of autologous epidermal melanocyte–keratinocyte cells suspension for cell therapy of vitiligo: A clinical evaluation and biometric assessment

    , Article Journal of Cosmetic Dermatology ; Volume 21, Issue 12 , 2022 , Pages 7147-7152 ; 14732130 (ISSN) Nilforoushzadeh, M. A ; Farshi, S ; Nouri, M ; Alavi, S ; Bayat Tork, B ; Jaffary, F ; Zare, S ; Sharif University of Technology
    John Wiley and Sons Inc  2022
    Abstract
    Introduction: Among several surgical treatments, the use of transplantation of epidermal cultured melanocytes or melanocytes–keratinocytes cell suspension has gained many researchers and dermatologists' attention as a new technique for the treatment of vitiligo. The present study aimed to transplant autologous epidermal melanocytes–keratinocytes cell suspension for the treatment of vitiligo. Methods: In this study, 15 volunteer patients aged between 18 and 45 years old were studied. The autologous melanocytes–keratinocytes cell suspension was then transplanted to the region after dermabrasion. The included patients were evaluated by VisioFace, MPA9, and Skin Scanner-DUB once before and 1, 2,... 

    3D calculation of absorbed dose for 131I-targeted radiotherapy: A monte carlo study

    , Article Radiation Protection Dosimetry ; Volume 150, Issue 3 , October , 2012 , Pages 298-305 ; 01448420 (ISSN) Saeedzadeh, E ; Sarkar, S ; Abbaspour Tehrani Fard, A ; Ay, M. R ; Khosravi, H. R ; Loudos, G ; Sharif University of Technology
    2012
    Abstract
    Various methods, such as those developed by the Medical Internal Radiation Dosimetry (MIRD) Committee of the Society of Nuclear Medicine or employing dose point kernels, have been applied to the radiation dosimetry of 131I radionuclide therapy. However, studies have not shown a strong relationship between tumour absorbed dose and its overall therapeutic response, probably due in part to inaccuracies in activity and dose estimation. In the current study, the GATE Monte Carlo computer code was used to facilitate voxel-level radiation dosimetry for organ activities measured in an . 131I-treated thyroid cancer patient. This approach allows incorporation of the size, shape and composition of... 

    Copper oxide nanoflakes as highly sensitive and fast response self-sterilizing biosensors

    , Article Journal of Materials Chemistry ; Volume 21, Issue 34 , Jul , 2011 , Pages 12935-12940 ; 09599428 (ISSN) Akhavan, O ; Ghaderi, E ; Sharif University of Technology
    2011
    Abstract
    Vertical copper oxide nanoflakes were synthesized on a Cu foil through oxidation in alkaline conditions. X-ray photoelectron spectroscopy showed that after exposing the nanoflakes to an Escherichia coli bacterial suspension, the outermost surface of the nanoflakes was chemically reduced through the glycolysis process of the bacteria. Current-voltage (I-V) characteristics of the nanoflakes (measured perpendicular to surface of the Cu foil by using conductive atomic force microscopy) indicated that electrical resistivity of the nanoflakes increased about one order of magnitude after exposure to the bacterial suspension. The nanoflakes reduced by the bacterial suspension could also be... 

    Controlled release of doxorubicin from electrospun PEO/chitosan/graphene oxide nanocomposite nanofibrous scaffolds

    , Article Materials Science and Engineering C ; Volume 48 , March , 2015 , Pages 384-390 ; 09284931 (ISSN) Ardeshirzadeh, B ; Aboutalebi Anaraki, N ; Irani, M ; Roshanfekr Rad, L ; Shamshiri, S ; Sharif University of Technology
    Elsevier Ltd  2015
    Abstract
    Polyethylene oxide (PEO)/chitosan (CS)/graphene oxide (GO) electrospun nanofibrous scaffolds were successfully developed via electrospinning process for controlled release of doxorubicin (DOX). The SEM analysis of nanofibrous scaffolds with different contents of GO (0.1, 0.2, 0.5 and 0.7 wt.%) indicated that the minimum diameter of nanofibers was found to be 85 nm for PEO/CS/GO 0.5% nanofibers. The π-π stacking interaction between DOX and GO with fine pores of nanofibrous scaffolds exhibited higher drug loading (98%) and controlled release of the DOX loaded PEO/CS/GO nanofibers. The results of DOX release from nanofibrous scaffolds at pH 5.3 and 7.4 indicated strong pH dependence. The... 

    Nanotechnology in diagnosis and treatment of coronary artery disease

    , Article Nanomedicine ; Volume 11, Issue 5 , 2016 , Pages 513-530 ; 17435889 (ISSN) Karimi, M ; Zare, H ; Bakhshian Nik, A ; Yazdani, N ; Hamrang, M ; Mohamed, E ; Sahandi Zangabad, P ; Moosavi Basri, S. M ; Bakhtiari, L ; Hamblin, M. R ; Sharif University of Technology
    Future Medicine Ltd 
    Abstract
    Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis.... 

    Identification of an aspidospermine derivative from borage extract as an anti-amyloid compound: A possible link between protein aggregation and antimalarial drugs

    , Article Phytochemistry ; Volume 140 , 2017 , Pages 134-140 ; 00319422 (ISSN) Kalhor, H. R ; Ashrafian, H ; Sharif University of Technology
    Elsevier Ltd  2017
    Abstract
    A number of human diseases, including Alzheimer's and Parkinson's have been linked to amyloid formation. To search for an anti-amyloidogenic product, alkaloid enriched extract from borage leaves was examined for anti-amyloidogenic activity using Hen Egg White Lysozyme (HEWL) as a model protein. After isolation of the plant extract using rHPLC, only one fraction indicated a significant bioactivity. TEM analysis confirmed a remarkable reduction of amyloid fibrils in the presence of the bioactive fraction. To identify the effective substance in the fraction, mass spectrometry, FTIR, and NMR were performed. Our analyses determined that the bioactive compound as... 

    Can lumbosacral orthoses cause trunk muscle weakness? A systematic review of literature

    , Article Spine Journal ; Volume 17, Issue 4 , 2017 , Pages 589-602 ; 15299430 (ISSN) Azadinia, F ; Ebrahimi Takamjani, E ; Kamyab, M ; Parnianpour, M ; Cholewicki, J ; Maroufi, N ; Sharif University of Technology
    Elsevier Inc  2017
    Abstract
    Background Wearing lumbosacral orthosis (LSO) is one of the most common treatments prescribed for conservative management of low back pain. Although the results of randomized controlled trials suggest effectiveness of LSO in reducing pain and disability in these patients, there is a concern that prolonged use of LSO may lead to trunk muscle weakness and atrophy. Purpose The present review aimed to evaluate available evidence in literature to determine whether LSO results in trunk muscle weakness or atrophy. Study Design This is a systematic review. Methods A systematic search of electronic databases including PubMed, Scopus, ScienceDirect, and Medline (via Ovid) followed by hand search of... 

    Nonlinear analysis of anesthesia dynamics by fractal scaling exponent

    , Article 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, 30 August 2006 through 3 September 2006 ; 2006 , Pages 6225-6228 ; 05891019 (ISSN); 1424400325 (ISBN); 9781424400324 (ISBN) Gifani, P ; Rabiee, H. R ; Hashemi, M. R ; Taslimi, P ; Ghanbari, M ; Sharif University of Technology
    2006
    Abstract
    The depth of anesthesia estimation has been one of the most research interests in the field of EEG signal processing in recent decades. In this paper we present a new methodology to quantify the depth of anesthesia by quantifying the dynamic fluctuation of the EEG signal. Extraction of useful information about the nonlinear dynamic of the brain during anesthesia has been proposed with the optimum Fractal Scaling Exponent. This optimum solution is based on the best box sizes in the Detrended Fluctuation Analysis (DFA) algorithm which have meaningful changes at different depth of anesthesia. The Fractal Scaling Exponent (FSE) Index as a new criterion has been proposed. The experimental results...