Search for: patterned-substrates
Article Physical Review E - Statistical, Nonlinear, and Soft Matter Physics ; Volume 86, Issue 1 , July , 2012 ; 15393755 (ISSN) ; Sharif University of Technology
Mesoscopic hydrodynamic equations are solved to investigate coarsening dynamics of two interacting nanodroplets on chemically patterned substrates. The effects of different parameters such as the surface chemical pattern, the slip length, the profile of the disjoining pressure, the size of the droplets, and the contact angles on the coarsening are studied. Our results reveal that the presence of a chemical heterogeneity can enhance or weaken the coarsening dynamics depending on the pattern type and positions of the droplets on the substrate. Also increasing the contact angles to values larger than a critical value may qualitatively change the coarsening process, and the profile of the...
Engineering of mature human induced pluripotent stem cell-derived cardiomyocytes using substrates with multiscale topography, Article Advanced Functional Materials ; Volume 28, Issue 19 , 2018 ; 1616301X (ISSN) ; Garbern, J. C ; Behzadi, S ; Hill, M. J ; Tresback, J. S ; Heydari, T ; Ejtehadi, M. R ; Ahmed, N ; Copley, E ; Aghaverdi, H ; Lee, R. T ; Farokhzad, O. C ; Mahmoudi, M ; Sharif University of Technology
Wiley-VCH Verlag 2018
Producing mature and functional cardiomyocytes (CMs) by in vitro differentiation of induced pluripotent stem cells (iPSCs) using only biochemical cues is challenging. To mimic the biophysical and biomechanical complexity of the native in vivo environment during the differentiation and maturation process, polydimethylsiloxane substrates with 3D topography at the micrometer and sub-micrometer levels are developed and used as cell-culture substrates. The results show that while cylindrical patterns on the substrates resembling mature CMs enhance the maturation of iPSC-derived CMs, sub-micrometer-level topographical features derived by imprinting primary human CMs further accelerate both the...