Loading...
Search for:
periodate-sodium
0.005 seconds
In situ forming interpenetrating hydrogels of hyaluronic acid hybridized with iron oxide nanoparticles
, Article Biomaterials Science ; Volume 3, Issue 11 , Aug , 2015 , Pages 1466-1474 ; 20474830 (ISSN) ; Shi, L ; Bagheri, R ; Kabiri, K ; Hilborn, J ; Ossipov, D. A ; Sharif University of Technology
Royal Society of Chemistry
2015
Abstract
Four derivatives of hyaluronic acid (HA) bearing thiol (HA-SH), hydrazide (HA-hy), 2-dithiopyridyl (HA-SSPy), and aldehyde groups (HA-al) respectively were synthesized. Thiol and 2-dithiopyridyl as well as hydrazide and aldehyde make up two chemically orthogonal pairs of chemo-selective functionalities that allow in situ formation of interpenetrating (IPN) disulfide and hydrazone networks simultaneously upon the mixing of the above derivatives at once. The formation of IPN was demonstrated by comparing it with the formulations of the same total HA concentration but lacking one of the reactive components. The hydrogel composed of all four components was characterized by a larger elastic...