Search for: pharmaceutical-industry
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    Moderating role of innovation culture in the relationship between organizational learning and innovation performance

    , Article Learning Organization ; Volume 26, Issue 3 , 2019 , Pages 289-303 ; 09696474 (ISSN) Ghasemzadeh, P ; Nazari, J. A ; Farzaneh, M ; Mehralian, G ; Sharif University of Technology
    Emerald Group Publishing Ltd  2019
    Purpose: Different studies have analyzed the relationship between organizational learning (OL) and innovation performance (IP). However, the question of how innovation culture (IC) affects the relationship between OL and IP remains unexplored. This study aims to examine the impact of IC on the relationship between OL and various dimensions of IP, including product, process and objective innovation. Design/methodology/approach: A research model was developed and performed based on the relevant literature in the field of OL, IC and IP. The hypotheses are tested with the data collected from companies operating in an intensive knowledge-based industry. Findings: Based on the results of 625... 

    Experimental characterization of stabilized suspensions caused by formation of nanoparticle halos

    , Article ASME 2014 12th International Conference on Nanochannels, Microchannels, and Minichannels, ICNMM 2014, Collocated with the ASME 2014 4th Joint US-European Fluids Engineering Division Summer Meeting ; 2014 ; ISBN: 9780791846278 Keramati, H ; Zabetian, M ; Saidi, M. H ; Mozafari, A. A ; Sharif University of Technology
    Suspension flow has an important role in various applications such as paint, material and pharmaceutical industries. Settling is considered as a resisting phenomenon in the processes dealing with suspensions. Using nanoparticles as an additive to micro-particulates has been studied in limited studies. This work presents an experimental investigation to assess the effectiveness of nanoparticles in reduction of suspension settling. Microscopic imaging and transmission measurement were used to analyze the stability factors in a container. Transmission analysis revealed that presence of nanoparticles in the suspension, decreased the sedimentation rate. Microscopy showed that the settling rate... 

    Optical nanoprobes for chiral discrimination

    , Article Analyst ; Volume 145, Issue 20 , 2020 , Pages 6416-6434 Bigdeli, A ; Ghasemi, F ; Fahimi Kashani, N ; Abbasi Moayed, S ; Orouji, A ; Jafar Nezhad Ivrigh, Z ; Shahdost Fard, F ; Hormozi Nezhad, M. R ; Sharif University of Technology
    Royal Society of Chemistry  2020
    Chiral discrimination has always been a hot topic in chemical, food and pharmaceutical industries, especially when dealing with chiral drugs. Enantiomeric recognition not only leads to better understanding of the mechanism of molecular recognition in biological systems, but may further assist in developing useful molecular devices in biochemical and pharmaceutical studies. By emerging nanotechnology and exploiting nanomaterials in sensing applications, a great deal of attention has been given to the design of optical nanoprobes that are able to discriminate enantiomers of chiral analytes. This review explains how engineering nanoparticles (NPs) with desired physicochemical properties allows... 

    Investigation and Comparison of Data Mining Techniques Used for Pharmaceutical Drug Consumption Pattern Prediction

    , M.Sc. Thesis Sharif University of Technology Bastani Allahabadi, Shahrzad (Author) ; Haji, Alireza (Supervisor) ; Fatahi Valilai, Omid (Co-Supervisor)
    Data mining is the process of extracting information from large data sets using algorithms and methods derived from the field of statistics, machine learning and database management systems. Data mining, popularly known as knowledge discovery in big data, enables companies and organizations to make informed decisions by collecting, aggregating, analyzing and accessing company data. The pharmaceutical industry is one of the most important levels of the drug supply chain, which has a significant impact on the healthcare sector of any society. In this context data mining can be used in various procedure such as discovery of a new medicine, sequential registration of clinical trials, combining... 

    A new order splitting model with stochastic lead times for deterioration items

    , Article International Journal of Systems Science ; Vol. 45, Issue. 9 , 2014 , pp. 1936-1954 ; ISSN: 00207721 Sazvar, Z ; Jokar, M. R. A ; Baboli, A ; Sharif University of Technology
    In unreliable supply environments, the strategy of pooling lead time risks by splitting replenishment orders among multiple suppliers simultaneously is an attractive sourcing policy that has captured the attention of academic researchers and corporate managers alike. While various assumptions are considered in the models developed, researchers tend to overlook an important inventory category in order splitting models: deteriorating items. In this paper, we study an order splitting policy for a retailer that sells a deteriorating product. The inventory system is modelled as a continuous review system (s, Q) under stochastic lead time. Demand rate per unit time is assumed to be constant over... 

    Micro and nanoscale technologies in oral drug delivery

    , Article Advanced Drug Delivery Reviews ; Volume 157 , 2020 , Pages 37-62 Ahadian, S ; Finbloom, J. A ; Mofidfar, M ; Diltemiz, S. E ; Nasrollahi, F ; Davoodi, E ; Hosseini, V ; Mylonaki, I ; Sangabathuni, S ; Montazerian, H ; Fetah, K ; Nasiri, R ; Dokmeci, M. R ; Stevens, M. M ; Desai, T. A ; Khademhosseini, A ; Sharif University of Technology
    Elsevier B.V  2020
    Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro- and nanoscale technologies, with an unprecedented ability to create, control, and measure micro- or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies.... 

    Immobilization of penicillin G acylase on non-porous ultrafine silica particles

    , Article Scientia Iranica ; Volume 12, Issue 3 , 2005 , Pages 295-299 ; 10263098 (ISSN) Fazelinia, H ; Kheirolomoom, A ; Sharif University of Technology
    Sharif University of Technology  2005
    In this paper, immobilization of penicillin G aclylase onto non-porous ultrafine silica particles has been studied. The amount of penicillin G acylase immobilized was increased by increasing the free enzyme concentration and, at 0.45 mg/ml concentration of the free enzyme, 80% of the enzyme was immobilized. The optimum pH for immobilization was found to be 7.0, close to the pl of the enzyme. Although immobilization of the enzyme on ultrafine silica particles with and without glutaraldehyde showed almost the same activities, the enzyme immobilized with glutaraldehyde retained its initial activity much longer during 40 cycle-repeated batches with a half life of 163.2 h. © Sharif University of... 

    Enterprise-wide Optimization in Batch Processes

    , M.Sc. Thesis Sharif University of Technology Moadeli, Behrad (Author) ; Rashtchian, Davood (Supervisor) ; Vafa, Ehsan (Supervisor)
    According to the competitive nature of process industries and the necessity of increasing the efficiency of supply, manufacturing, and distribution operations, the optimization of such activities with an integrated attitude has become a major goal of research in the field of Process Systems Engineering. Lying at the interface of Chemical Engineering and Operations Research, enterprise-wide optimization has become a tool that enables the integrated optimization of different components of an industry to maximize the net profit. Design, Planning, Scheduling, and Control are four major operational items within such an optimization that may be simultaneously considered; among which, Planning and... 

    Hydrothermal synthesis of CuO nanoparticles: Study on effects of operational conditions on yield, purity, and size of the nanoparticles

    , Article Industrial and Engineering Chemistry Research ; Volume 50, Issue 6 , February , 2011 , Pages 3540-3554 ; 08885885 (ISSN) Outokesh, M ; Hosseinpour, M ; Ahmadi, S. J ; Mousavand, T ; Sadjadi, S ; Soltanian, W ; Sharif University of Technology
    Hydrothermal synthesis of CuO nanoparticles under near-critical and supercritical conditions was investigated from two different standpoints in the current study. The first standpoint was optimization of "yield", "purity", and "size of the nanoparticles" that were optimized at T = 500 °C, time = 2 h, [Cu(NO3)2] = 0.1 mol dm-3, and pH 3. This was achieved by undertaking an orthogonal experiment design methodology and performing different instrumental analyses, such as X-ray diffractometry, inductively coupled plasma spectrometry, and transmission electron microscopy, along with treatment of the data by analysis of variance (ANOVA). The second goal of the study was elucidation of the... 

    Potential of plant species for phytoremediation of metformin from solutions

    , Article International Journal of Environmental Science and Technology ; Volume 15, Issue 3 , March , 2018 , Pages 593-598 ; 17351472 (ISSN) Moogouei, R ; Borghei, M ; Hosseini, S ; Tajadod, G ; Sharif University of Technology
    Center for Environmental and Energy Research and Studies  2018
    Phytoremediation has been applied for treating an extensive range of environmental contaminants such as anti-diabetic drug metformin which is increasingly found as environmental contaminant. These contaminants are released to the environment via human and veterinary medicine and pharmaceutical industries. In this study, native plant capabilities for uptake of metformin from wastewater were investigated. Moreover, uptake rate of metformin was studied in two different concentrations of 20 and 50 mg l−1 metformin solution by Amaranthus retroflexus, Ricinus communis, Brassica napus, Celosia cristata, Helianthus annuus and Phragmites australis. The results showed that after exposing to 20 mg l−1... 

    Flow regime mapping for a two-phase system of aqueous alginate and water droplets in T-junction geometry

    , Article Physics of Fluids ; Volume 33, Issue 7 , 2021 ; 10706631 (ISSN) Mehraji, S ; Saadatmand, M ; Sharif University of Technology
    American Institute of Physics Inc  2021
    Microfluidic systems are an interesting topic for investigation due to their wide-spreading applications. Nowadays, polymeric solutions are used mainly for the generation of microparticles in biomedical engineering, food, and pharmaceutical industries. Droplet-based microfluidic devices have proposed an extensive interest in many applications such as chemical/biological/nanomaterial preparation to understand deeply the droplet size and formation in microchannels. However, numerous experimental and numerical studies have been done for oil-water combination, polymeric solutions behavior in the presence of oil has not been investigated widely. Therefore, it is important to understand the...