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pharmacokinetic-model
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Unified model of brain tissue microstructure dynamically binds diffusion and osmosis with extracellular space geometry
, Article Physical Review E - Statistical, Nonlinear, and Soft Matter Physics ; Volume 94, Issue 3 , 2016 ; 15393755 (ISSN) ; Fotouhi, M ; Vejdani, K ; Kamali Zare, P ; Sharif University of Technology
American Physical Society
2016
Abstract
We present a universal model of brain tissue microstructure that dynamically links osmosis and diffusion with geometrical parameters of brain extracellular space (ECS). Our model robustly describes and predicts the nonlinear time dependency of tortuosity (λ=D/D∗) changes with very high precision in various media with uniform and nonuniform osmolarity distribution, as demonstrated by previously published experimental data (D = free diffusion coefficient, D∗ = effective diffusion coefficient). To construct this model, we first developed a multiscale technique for computationally effective modeling of osmolarity in the brain tissue. Osmolarity differences across cell membranes lead to changes...
Fabrication and evaluation of controlled release of doxorubicin loaded UiO-66-NH2 metal organic frameworks
, Article International Journal of Engineering, Transactions B: Applications ; Volume 34, Issue 8 , 2021 , Pages 1874-1881 ; 1728144X (ISSN) ; Hassanzadeh Nemati, N ; Ramezani Saadatabadi, A ; Sadrnezhaad, S. K ; Sharif University of Technology
Materials and Energy Research Center
2021
Abstract
The metal-organic frameworks (MOFs) due to their large specific surface area and high biocompatibility are suitable as carriers for drug delivery systems (DDSs). In the present study, doxorubicin (DOX) as an anticancer drug was loaded into UiO-66-NH2 MOFs to decrease the adverse side effects of pristine DOX use and to increase its efficiency through the controlled release of DOX from MOFs. The MOFs were synthesized via microwave heating method and characterized using X-ray diffraction, scanning electron microscopy, and Brunauer-Emmett- Teller analysis. The drug loading efficiency, drug release profiles from synthesized MOFs and pharmacokinetic studies were investigated. The biocompatibility...