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Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing
, Article Lab on a Chip ; Volume 20, Issue 22 , 2020 , Pages 4205-4214 ; Zhang, S ; Cui, Q ; Ni, J ; Wang, X ; Cheng, X ; Alem, H ; Tebon, P ; Xu, C ; Guo, C ; Nasiri, R ; Moreddu, R ; Yetisen, A. K ; Ahadian, S ; Ashammakhi, N ; Emaminejad, S ; Jucaud, V ; Dokmeci, M.R ; Khademhosseini, A ; Sharif University of Technology
Royal Society of Chemistry
2020
Abstract
Microchannels in hydrogels play an essential role in enabling a smart contact lens. However, microchannels have rarely been created in commercial hydrogel contact lenses due to their sensitivity to conventional microfabrication techniques. Here, we report the fabrication of microchannels in poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels that are used in commercial contact lenses with a three-dimensional (3D) printed mold. We investigated the corresponding capillary flow behaviors in these microchannels. We observed different capillary flow regimes in these microchannels, depending on their hydration level. In particular, we found that a peristaltic pressure could reinstate flow in...
Synthesis, Characterization and Application of Porous Bioactive Glasses-Based Nanostructures in Bone Tissue Engineering
, Ph.D. Dissertation Sharif University of Technology ; Bagherzadeh, Mojtaba (Supervisor) ; Baheiraei, Nafiseh (Co-Supervisor)
Abstract
In the upcoming research, with the aim of bone tissue engineering and achieving a new structure, a scaffold based on polyhema (PHEMA) and gelatin (Gel), which are biocompatible polymers for bone tissue, was made and evaluated. Also, in order to improve the bioactivity and mechanical properties, bioactive glass alone (BG45S5) or together with strontium (BG-Sr) was used in the scaffold structure. and chemical by conducting FTIR, XRD, SEM, mechanical strength, bioactivity measurement, contact angle, water absorption and degradation tests. Biological investigations were done using mesenchymal stem cells derived from human bone marrow and with the help of MTT evaluations and SEM photography. The...