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Enzymatic synthesis of amoxicillin with immobilized penicillin G acylase
, Article Scientia Iranica ; Volume 17, Issue 1 C , 2010 , Pages 106-113 ; 10263098 (ISSN) ; Borghei, G ; Vafi, L ; Roostaazad, R ; Sharif University of Technology
2010
Abstract
The synthesis of amoxicillin with immobilized penicillin G acylase (PGA) in aqueous medium was investigated. The parameters studied were: time course of amoxicillin production, concentration of substrates: hydroxyphenylglycine methyl ester (HPGM) and 6-aminopeicillanic acid (6-APA) and the. effect of enzyme (PGA) content and pH, under variable and constant conditions and temperature variations. In the study of two substrate concentration on amoxicillin production, impressive results were obtained for a 1/3 ratio of 6-amino penicillanic acid (6-APA) and hydroxyl-phenylglycine methyl ester (HPGM). The. synthesis of amoxicillin was preferable at constant pH rather than a variable one. Other...