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In vitro bactericidal and drug release properties of vancomycin-amino surface functionalized bioactive glass nanoparticles
, Article Materials Chemistry and Physics ; Volume 241 , 2020 ; Ghorbani, M ; Bagheri, K.P ; Shokrgozar, M. A ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
Bioactive glass has been used clinically in bone repair applications for bone grafting because of its prominent physiochemical and osteogenic properties. Various attempts have been made to enhance bioactive glass efficiency in combination with other biomaterials such as antibiotics and growth factors. In present study, we developed a modification of bioactive glass nanoparticles that insured long term antibacterial effect. Bioactive glass nanoparticles (BGNs) were functionalized with (3-Aminopropyl) triethoxysilane (APTS), then vancomycin (VAN) was immobilized onto BGNs-APTS via EDC/NHS cross-linking process. Another study group namely BGNs-VAN was synthesized as a control group without any...