Sharif Digital Repository

In this study, different concentrations of ascorbic acid (50, 100 and 200 μg/mL) were added to the liquid phase of a calcium phosphate cement (CPC). The cements were immersed in simulated body fluid (SBF) for different intervals and physical, physicochemical and mechanical properties of them were evaluated. The release of added ascorbic acid from CPCs into the SBF solution was also studied. From the results, both setting time and injectability of CPC decreased by adding ascorbic acid, however the compressive strength was sharply increased before soaking in SBF solution. But, the compressive strength values of all cements (with or without ascorbic acid) soaked in SBF solution for more than 7... 

In the article, a bilayer nanocomposite scaffold made of oxidized alginate (OAL), gelatin (G), and silk fibroin (SF) has been prepared via combining electrospinning, in situ gas foaming, in situ crosslinking and freeze drying methods. The physicochemical and mechanical properties, as well as thermal stability of the proposed composite, have been investigated by SEM, FTIR, XRD, tensile, and TGA analysis. The data indicate that structure and degree of crosslinking play a vital role in adjusting the physical and mechanical properties of composite scaffolds. Further, the authors find a favorable adipose-derived mesenchymal stem cell's (AMSC) attachment and distribution within this novel... 

Blend drug-loading method in electrospun scaffolds has gained much attention as a cost-effective and simple delivery system in regenerative medicine. However, it has some drawbacks, such as the burst release of encapsulated drugs and denaturing active agents in harsh organic solvents. In this study, a new silk fibroin-gelatin (SF–G) fibrous sheet has been introduced as an engineered scaffold and a straightforward drug delivery system for skin tissue engineering applications. The hybrid sheets have been prepared via co-electrospinning and in-situ crosslinking methods without corrosive solvents and toxic crosslinking agents. To evaluate the proposed scaffold as a controlled release system, the... 

Blend drug-loading method in electrospun scaffolds has gained much attention as a cost-effective and simple delivery system in regenerative medicine. However, it has some drawbacks, such as the burst release of encapsulated drugs and denaturing active agents in harsh organic solvents. In this study, a new silk fibroin-gelatin (SF–G) fibrous sheet has been introduced as an engineered scaffold and a straightforward drug delivery system for skin tissue engineering applications. The hybrid sheets have been prepared via co-electrospinning and in-situ crosslinking methods without corrosive solvents and toxic crosslinking agents. To evaluate the proposed scaffold as a controlled release system, the...