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Selection and simulation of a proper microfluidic for hepatocyte culture
, Article 2015 22nd Iranian Conference on Biomedical Engineering, ICBME 2015, 25 November 2015 through 28 November 2015 ; 2015 , Pages 65-69 ; 9781467393515 (ISBN) ; Firoozabadi, B ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2015
Abstract
The advent of microfluidics as suitable environments for culturing cells is associated with some challenges as shear stresses applied on the cells. Moreover, among all factors needed for cell viability, feeding hepatocytes with adequate oxygen is of great importance due to their high demand for oxygen compared the other cell types. In this paper three kinds of geometries has been studied in order that shear stresses would be in allowed range and provision of hepatocytes with sufficient oxygen concentrations has been ensured as well. In addition to supplying hepatocytes with oxygen, the range of its concentration has been adjusted in physiologic value so that it would be practical for further...
Effects of different corneal ring segments with identical total arc length on keratoconic eyes: a finite element study
, Article 26th National and 4th International Iranian Conference on Biomedical Engineering, ICBME 2019, 27 November 2019 through 28 November 2019 ; 2019 , Pages 1-3 ; 9781728156637 (ISBN) ; Sajadi, S. B ; Khanlari, M ; Gholami, M ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2019
Abstract
Keratoconus (KC) is a progressive corneal disease. It is mostly characterized by corneal thinning and irregular steepening as well as formation of cone-shaped regions on the cornea. Amongst treatment modalities, implantation of Intrastromal Corneal Ring Segments (ICRSs) could decrease corneal surface irregularities. However, controversy exists over the selection of proper ICRSs. Here, the aim was to compare the effects of two sets of ICRSs. The ICRSs were identical both in cross-section and total arc length. The results showed that under normal physiological range of intraocular pressures (IOPs), the two selected ICRSs caused slightly different deformations in the same in-silico keratoconic...