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Expression of PIAS genes in migraine patients
, Article Journal of Molecular Neuroscience ; Volume 71, Issue 10 , 2021 , Pages 2053-2059 ; 08958696 (ISSN) ; Hesami, O ; Nazer, N ; Sayad, A ; Taheri, M ; Sharif University of Technology
Humana Press Inc
2021
Abstract
Migraine is a complex disabling condition which is associated with dysregulation of several pathways particularly those being associated with immune responses. In order to assess contribution of protein inhibitor of activated STAT (PIAS) in the pathogenesis of migraine, we quantified expression levels of PIAS1–PIAS4 genes in the circulation of patients with migraine compared with controls. Expression of PIAS1 was substantially lower in total migraineurs compared with controls (ratio of mean expressions (RME) = 0.18, SE = 0.29, P value < 0.001) and in both male and female migraineurs compared with sex-matched controls. Expression of PIAS2 was lower in migraineurs without aura compared with...