Search for: pilot-study
Article BMC Oral Health ; Volume 21, Issue 1 , 2021 ; 14726831 (ISSN) ; Gholami, L ; Badrlou, E ; Sadeghpour, S ; Nazer, N ; Shadnoush, M ; Sayad, A ; Taheri, M ; Sharif University of Technology
BioMed Central Ltd 2021
Background: Periodontitis is a chronic inflammatory disorder with a complex etiology. Long non-coding RNAs (lncRNAs) have been shown to affect pathoetiology of periodontitis. We aimed at identification of expression of five lncRNAs, namely Linc0116, Linc00667, CDK6-AS1, FENDRR and DIRC3 in the circulation and gingival tissues of these patients compared with healthy controls. Methods: In a pilot case–control study, we compared expressions of Linc0116, Linc00667, CDK6-AS1, FENDRR and DIRC3 lncRNAs between blood and tissue samples of patients with periodontitis and healthy controls using real time quantitative PCR technique. The present work was performed on samples got from 26 patients with...
Rehabilitation after ACL injury: A fluoroscopic study on the effects of type of exercise on the knee sagittal plane arthrokinematics, Article BioMed Research International ; Volume 2013 , July , 2013 ; 23146133 (ISSN) ; Esfandiarpour, F ; Shakourirad, A ; Salehi, R ; Akbar, M ; Farahmand, F ; Sharif University of Technology
A safe rehabilitation exercise for anterior cruciate ligament (ACL) injuries needs to be compatible with the normal knee arthrokinematics to avoid abnormal loading on the joint structures. The objective of this study was to measure the amount of the anterior tibial translation (ATT) of the ACL-deficient knees during selective open and closed kinetic chain exercises. The intact and injured knees of fourteen male subjects with unilateral ACL injury were imaged using uniplanar fluoroscopy, while the subjects performed forward lunge and unloaded/loaded open kinetic knee extension exercises. The ATTs were measured from fluoroscopic images, as the distance between the tibial and femoral reference...
Article Biomarkers ; Volume 21, Issue 6 , 2016 , Pages 479-489 ; 1354750X (ISSN) ; Aliannejad, R ; Rezaei Tavirani, M ; Arefi Oskouie, A ; Naseri, M. T ; Parastar, H ; Aliakbarzadeh, G ; Fathi, F ; Taheri, S ; Sharif University of Technology
Taylor and Francis Ltd
Sulfur Mustard (SM) is a potent alkylating agent and its effects on cells and tissues are varied and complex. Due to limitations in the diagnostics of sulfur mustard exposed individuals (SMEIs) by noninvasive approaches, there is a great necessity to develop novel techniques and biomarkers for this condition. We present here the first nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC/MS) metabolic profiling of serum from and healthy controls to identify novel biomarkers in blood serum for better diagnostics. Of note, SMEIs were exposed to SM 30 years ago and that differences between two groups could still be found. Pathways in which differences between SMEIs and...
Article Journal of Neuroscience Methods ; Volume 341 , 2020 ; Hojjati, H ; Aghajan, H ; Sharif University of Technology
Elsevier B.V 2020
Background: While decoding visual and auditory stimuli using recorded EEG signals has enjoyed significant attention in the past decades, decoding olfactory sensory input from EEG data remains a novelty. Recent interest in the brain's mechanisms of processing olfactory stimuli partly stems from the association of the olfactory system and its deficit with neurodegenerative diseases. New Methods: An olfactory stimulus decoder using features that represent nonlinear behavior content in the recorded EEG data has been introduced for classifying 4 olfactory stimuli in 5 healthy male subjects. Results: We show that by using nonlinear and chaotic features, a subject-specific classifier can be...
A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial, Article European Journal of Clinical Nutrition ; Volume 73, Issue 9 , 2019 , Pages 1224-1235 ; 09543007 (ISSN) ; Mirhafez, S. R ; Dehabeh, M ; Hariri, M ; Azimi Nezhad, M ; Nobakht M. Gh, B. F ; Sharif University of Technology
Nature Publishing Group 2019
Background/Objectives: Curcumin, a natural polyphenol compound in the spice turmeric, has been found to have potent anti-oxidative and anti-inflammatory activity. Curcumin may treat non-alcoholic fatty liver disease (NAFLD) through its beneficial effects on biomarkers of oxidative stress (OS) and inflammation, which are considered as two feature of this disease. However, the effects of curcumin on NAFLD have been remained poorly understood. This investigation evaluated the effects of administrating curcumin on metabolic status in NAFLD patients. Subjects/Methods: Fifty-eight NAFLD patients participated in a randomized, double-blind, placebo-controlled parallel design of study. The subjects...
Metabolomics analysis of the saliva in patients with chronic hepatitis b using nuclear magnetic resonance: A pilot study, Article Iranian Journal of Basic Medical Sciences ; Volume 22, Issue 9 , 2019 , Pages 1044-1049 ; 20083866 (ISSN) ; Mohamadkhani, A ; Chashmniam, S ; Shahnazari, P ; Amini, M ; Arjmand, B ; Malekzadeh, R ; Nobakht Motlagh Ghoochani, B. F ; Sharif University of Technology
Mashhad University of Medical Sciences 2019
Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the saliva metabolic profile of patients with chronic hepatitis B infection and to identify underlying mechanisms as well as potential biomarkers associated with the disease. Materials and Methods: Saliva from 16 healthy subjects and 20 patients with chronic hepatitis B virus were analyzed by nuclear magnetic resonance (NMR). Then, multivariate statistical analysis was performed to identify...
The metabolomics signature associated with responsiveness to steroid therapy in focal segmental glomerulosclerosis: A pilot study, Article Revista de Investigacion Clinica ; Volume 71, Issue 2 , 2019 , Pages 106-115 ; 00348376 (ISSN) ; Kalantari, S ; Nafar, M ; Boroumandnia, N ; Sharif University of Technology
Instituto Nacional de la Nutricion Salvador Zubiran 2019
Background: Focal segmental glomerulosclerosis (FSGS) is considered one of the most severe glomerular diseases and around 80% of cases are resistant to steroid treatment. Since a large proportion of steroid-resistant (SR) FSGS patients progress to end-stage renal disease, other therapeutic strategies may benefit this population. However, identification of non-invasive biomarkers to predict this high-risk population is needed. Objective: We aimed to identify the biomarker candidates to distinguish SR from steroid-sensitive (SS) patients using metabolomics approach and to identify the possible molecular mechanism of resistance. Methods: Urine was collected from biopsy-proven FSGS patients...
Postural control learning dynamics in Parkinson's disease: Early improvement with plateau in stability, and continuous progression in flexibility and mobility, Article BioMedical Engineering Online ; Volume 19, Issue 1 , 2020 ; Behzadipour, S ; Schouten, A. C ; Taghizadeh, G ; Firoozbakhsh, K ; Sharif University of Technology
BioMed Central Ltd 2020
Background: Balance training improves postural control in Parkinson's disease (PD). However, a systematic approach for the development of individualized, optimal training programs is still lacking, as the learning dynamics of the postural control in PD, over a training program, are poorly understood. Objectives: We investigated the learning dynamics of the postural control in PD, during a balance-training program, in terms of the clinical, posturographic, and novel model-based measures. Methods: Twenty patients with PD participated in a balance-training program, 3 days a week, for 6 weeks. Clinical tests assessed functional balance and mobility pre-training, mid-training, and post-training....