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Water promoted Michael addition of secondary amines: To α,β- unsaturated carbonyl compounds under microwave irradiation
, Article Synthetic Communications ; Volume 30, Issue 4 , 2000 , Pages 643-650 ; 00397911 (ISSN) ; Mohammadi, M ; Hosseinnia, A ; Sharif University of Technology
Marcel Dekker Inc
2000
Abstract
A rapid Michael addition of secondary amines to α,β-unsaturated carbonyl compounds has been achieved in good to excellent yields in the presence of water under microwave irradiation. In the absence of water and under conventional method the reaction does not proceed or take place in very low yield after a long reaction time
Solute-solvent interaction effects on second-order rate constants of reaction between 1-chloro-2,4-dinitrobenzene and aniline in alcohol-water mixtures
, Article International Journal of Chemical Kinetics ; Volume 37, Issue 2 , 2005 , Pages 90-97 ; 05388066 (ISSN) ; Gholami, M. R ; Sharif University of Technology
2005
Abstract
The second-order rate coefficients for aromatic nucleophilic substitution reaction between 1-chloro-2,4-dinitrobenzene and aniline have been measured in aqueous solutions of ethanol and methanol at 25°C. The plots of rate constants versus mole fraction of water show a maximum in all-aqueous solutions. The effect of four empirical solvent parameters including hydrogen bond donor acidity (α), dipolarity/polarizability (π*). normalized polarity (ETN), and solvophobicity (Sp) has been investigated. This investigation has been carried out by means of simple and multiple regression models A dual-parameter equation of log k2 versus Sp and α was obtained in all-aqueous solutions (n = 41, r = 0.962,...