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    Antibacterial and antifungal activity of methanolic extracts of Salix alba L. against various disease causing pathogens

    , Article Brazilian journal of biology = Revista brasleira de biologia ; Volume 83 , 2021 , Pages e243332- ; 16784375 (ISSN) Javed, B ; Farooq, F ; Ibrahim, M ; Abbas, H. A. B ; Jawwad, H ; Zehra, S. S ; Ahmad, H. M ; Sarwer, A ; Malik, K ; Nawaz, K ; Sharif University of Technology
    NLM (Medline)  2021
    The present study was aimed to manifest the antibacterial and antifungal activity of methanolic extracts of Salix alba L. against seven Gram-positive and Gram-negative bacterial pathogens e.g. Streptococcus pyogenes, Staphylococcus aureus (1), S. aureus (2), Shigella sonnei, Escherichia coli (1), E. coli (2) and Neisseria gonorrhoeae and three fungal isolates from the air such as Aspergillus terreus, A. ornatus, and Rhizopus stolonifer. Two different serotypes of S. aureus and E. coli were used. The agar well-diffusion method results showed the dose-dependent response of plant extracts against bacterial and fungal strains while some organisms were found resistant e.g. E. coli (1), S. sonnei,... 

    Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of veronica persica phenolic-rich extracts

    , Article Cellular and Molecular Biology ; Volume 62, Issue 6 , 2016 , Pages 80-85 ; 01455680 (ISSN) Sharifi Rad, M ; Tayeboon, G. S ; Sharifi Rad, J ; Iriti, M ; Varoni, E. M ; Razazi, S ; Sharif University of Technology
    Cellular and Molecular Biology Association  2016
    Veronica genus (Plantaginaceae) is broadly distributed in different habitats. In this study, the inhibitory activity of free soluble and conjugated phenolic extracts of Veronica persica on key enzymes associated to type 2 diabetes (α-glucosidase and α-amylase) and hypertension (angiotensin I converting enzyme, ACE) was assessed, as well as their antioxidant power. Our results showed that both the extracts inhibited α-amylase, α-glucosidase and ACE in a dose-dependent manner. In particular, free phenolic extract significantly (P < 0.05) inhibited α-glucosidase (IC50 532.97 μg/mL), whereas conjugated phenolic extract significantly (P < 0.05) inhibited a-amylase (IC50 489.73 μg/mL) and ACE... 

    Identification of an aspidospermine derivative from borage extract as an anti-amyloid compound: A possible link between protein aggregation and antimalarial drugs

    , Article Phytochemistry ; Volume 140 , 2017 , Pages 134-140 ; 00319422 (ISSN) Kalhor, H. R ; Ashrafian, H ; Sharif University of Technology
    Elsevier Ltd  2017
    A number of human diseases, including Alzheimer's and Parkinson's have been linked to amyloid formation. To search for an anti-amyloidogenic product, alkaloid enriched extract from borage leaves was examined for anti-amyloidogenic activity using Hen Egg White Lysozyme (HEWL) as a model protein. After isolation of the plant extract using rHPLC, only one fraction indicated a significant bioactivity. TEM analysis confirmed a remarkable reduction of amyloid fibrils in the presence of the bioactive fraction. To identify the effective substance in the fraction, mass spectrometry, FTIR, and NMR were performed. Our analyses determined that the bioactive compound as... 

    Study of epithelial differentiation and protein expression of keratinocyte-mesenchyme stem cell co-cultivation on electrospun nylon/B. vulgaris extract composite scaffold

    , Article Materials Science and Engineering C ; Volume 75 , 2017 , Pages 653-662 ; 09284931 (ISSN) Hosseinzadeh, S ; Soleimani, M ; Vossoughi, M ; Ranjbarvan, P ; Hamedi, S ; Zamanlui, S ; Mahmoudifard, M ; Sharif University of Technology
    Employing of the composite electrospun scaffold containing herbal extract in conjugation with co-culturing of cells can open up new window to the design of efficient biomaterials for skin tissue regeneration. Here, we introduce the synergistic effect of composite electrospun nanofibrous scaffold of nylon66 loaded with Beta vulgaris (B. vulgaris) (extract of beet roots, a plants whose widely used in Iranian folk medicine as wound healing medicine) and co-culture of mesenchymal stem-cells (MSCs)-human keratinocyte (H-keratino) differentiation towards epithelial lineage. In vitro biocompatibility was examined through MTT assay and epithelial differentiation checked by real-time PCR and... 

    Evaluation of the Performance of Sheng (Tragopogon Buphthalmos Boiss) Extract as a Green Corrosion Inhibitor in High Concentration Hydrochloric Acid Solutions

    , M.Sc. Thesis Sharif University of Technology Bahramnejad, Hamed (Author) ; Afshar, Abdollah (Supervisor)
    In this study, the extract of Tragopogon buphthalmos Boiss was investigated as a green or environmentally friendly corrosion inhibitor for mild carbon steels in high concentration hydrochloric acid solutions. Tragopogon buphthalmos Boiss was extracted using the extraction method of digestion at 50 ° C assisted by ultrasonic bath. Water-ethanol-acetone solvents were used in ratios of 30:35:35, respectively. The ratio of plant volume to solvent volume was one to ten. The container containing the extract was placed in a bath water at 50 ° C until the extract was in the form of gum, then stored at -15 ° C In a freezer. Infrared Fourier transform spectroscopy (FTIR) was used to determine the... 

    A scenario tree approach to multi-period project selection problem using real-option valuation method

    , Article International Journal of Advanced Manufacturing Technology ; Volume 56, Issue 1-4 , 2011 , Pages 411-420 ; 02683768 (ISSN) Rafiee, M ; Kianfar, F ; Sharif University of Technology
    Multistage stochastic programs are effective for solving long-term planning problems under uncertainty. Multi-period project portfolio selection problems can be modeled by multistage stochastic programs. These models utilize a set of scenarios and corresponding probabilities to model the multivariate random data process (costs or revenues, available budget, chance of success). For most practical problems, the optimization problem that contains all possible scenarios is too large. Due to computational complexity, this program is often approximated by a model involving a (much) smaller number of scenarios. The scenario reduction algorithms determine a subset of the initial scenario set and... 

    On a bounded budget network creation game

    , Article Annual ACM Symposium on Parallelism in Algorithms and Architectures, 4 June 2011 through 6 June 2011, San Jose, CA ; June , 2011 , Pages 207-214 ; 9781450307437 (ISBN) Ehsani, S ; Fazli, M ; Mehrabian, A ; Sadeghian Sadeghabad, S ; Safari, M ; Saghafian, M ; Shokat Fadaee, S ; Sharif University of Technology
    We consider a network creation game in which, each player (vertex) has a limited budget to establish links to other players. In our model, each link has a unit cost and each agent tries to minimize its cost which is its local diameter or its total distance to other players in the (undirected) underlying graph of the created network. Two variants of the game are studied: in the MAX version, the cost incurred to a vertex is the maximum distance between that vertex and other vertices, and in the SUM version, the cost incurred to a vertex is the sum of distances between that vertex and other vertices. We prove that in both versions pure Nash equilibria exist, but the problem of finding the best... 

    A simple and efficient total synthesis of (±)-danshexinkun A, a bioactive diterpenoid from Salvia miltiorrhiza

    , Article Tetrahedron Letters ; Volume 51, Issue 3 , 2010 , Pages 540-542 ; 00404039 (ISSN) Matloubi Moghaddam, F ; Moridi Farimani, M ; Sharif University of Technology
    An efficient 12-step route for the synthesis of the diterpenoid quinone (±)-danshexinkun A in 23% overall yield from the corresponding highly substituted stilbene using a photocyclization strategy is described  

    Insight into the corrosion inhibition of Biebersteinia multifida root extract for carbon steel in acidic medium

    , Article Science of the Total Environment ; Volume 836 , 2022 ; 00489697 (ISSN) Khayatkashani, M ; Soltani, N ; Tavakkoli, N ; Nejatian, A ; Ebrahimian, J ; Mahdi, M. A ; Salavati Niasari, M ; Sharif University of Technology
    Elsevier B.V  2022
    In this project, the protective effect of Biebersteinia multifida root extract (BMRE) against corrosion of 1018 low carbon steel (1018LCS) in HCl solutions was appraised by assessing weight loss, electrochemical impedance spectroscopy (EIS), and polarization at 25 °C. The maximum inhibitory efficacy for the concentration of 1 g/l of the BMRE was 92.8% at 25 °C after 2 h and increased to 95.3% after 24 h of immersion. Polarization experiments have shown that the extract in acidic solutions can act as a mixed corrosion inhibitor. The corrosion inhibitory efficacy of BMRE decreased with increasing temperature, and at all temperature settings studied, the adsorption of BMRE molecules on 1018 LCS... 

    A new hierarchal and scalable architecture for performance enhancement of large scale underwater sensor networks

    , Article ISCI 2011 - 2011 IEEE Symposium on Computers and Informatics, 20 March 2011 through 22 March 2011, Kuala Lumpur ; 2011 , Pages 520-525 ; 9781612846903 (ISBN) Hamidzadeh, M ; Forghani, N ; Movaghar, A ; IEEE Advancing Technology for Humanity; IEEE Computer Society; IEEE Malaysia Computer Chapter; IEEE Malaysia; IEEE Malaysia Power Electron. (PEL)/Ind.; Electron. (IE)/ Ind. Appl. (IA) Jt. Chapter ; Sharif University of Technology
    The different characteristics of UWSN and trade off between UWSN and WSN, have been discussed in many researches. Here, we aim to propose a new architecture for very large scale underwater sensor network. In deployment part of sensors, topology plays a crucial role in issues like communication performance, power consumption, network reliability and fault tolerance capabilities. Hence, it is so critical and should be analyzed how we deploy sensors in targets environment. For instance, to improve reliability of our networks in harsh conditions, it is so important to avoid deploying underwater sensors with single point of failure and bottleneck. For this purpose, we present enhanced clustering... 

    Performance analysis of lattice-reduction algorithms for a novel LR-compatible K-Best MIMO detector

    , Article Proceedings - IEEE International Symposium on Circuits and Systems ; 2011 , Pages 701-704 ; 02714310 (ISSN) ; 9781424494736 (ISBN) Youssef, A ; Shabany, M ; Gulak, P. G ; Sharif University of Technology
    Lattice Reduction (LR) has been proposed as a method to enhance the performance of MIMO detectors such as ZF, MMSE and V-BLAST. Until recently, the application of LR to the superior K-Best tree-search detection algorithm was not practical due to the significant increase in complexity of K-Best as a result of the distortion of tree symmetry caused by LR. However, in our recently published work we developed an innovative K-Best algorithm to accommodate tree-asymmetry with no additional complexity. In this work, we build on this result and perform a detailed analysis of the effect of various LR algorithms on the performance of LR-aided K-Best. We show that LLL and Seysen provide equivalent... 

    An efficient distributed group key management using hierarchical approach with Diffie-Hellman and symmetric algorithm: DHSA

    , Article 2011 International Symposium on Computer Networks and Distributed Systems, CNDS 2011, 23 February 2011 through 24 February 2011, Tehran ; 2011 , Pages 49-54 ; 9781424491544 (ISBN) Mortazavi, S. A ; Pour, A. N ; Kato, T ; Sharif University of Technology
    This paper proposes an efficient many-to-many group key management protocol in distributed group communication. In this protocol, group members are managed in the hierarchical manner logically. Two kinds of keys are used, asymmetric and symmetric keys. The leaf nodes in the key tree are the asymmetric keys of the corresponding group members and all the intermediate node keys are symmetric keys assigned to each intermediate node. For asymmetric key, Diffie-Hellman key agreement is introduced. To calculate intermediate node keys, members use codes assigned to each intermediate node key tree. Group members calculate intermediate node keys rather than distributed by a sponsor member. The... 

    UV-prepared salep-based nanoporous hydrogel for controlled release of tetracycline hydrochloride in colon

    , Article Journal of Photochemistry and Photobiology B: Biology ; Volume 102, Issue 3 , March , 2011 , Pages 232-240 ; 10111344 (ISSN) Bardajee, G. R ; Pourjavadi, A ; Ghavami, S ; Soleyman, R ; Jafarpour, F ; Sharif University of Technology
    A highly swelling nanoporous hydrogel (NPH) was synthesized via UV-irradiation graft copolymerization of acrylic acid (AA) onto salep backbone and its application as a carrier matrix for colonic delivery of tetracycline hydrochloride (TH) was investigated. Optimized synthesis of the hydrogel was performed by the classic method. The swelling behavior of optimum hydrogel was measured in different media. The hydrogel formation was confirmed by Fourier transform infrared spectroscopy (FTIR) and thermo-gravimetric analysis (TGA/DTG/DTA). The study of the surface morphology of hydrogels using SEM showed a nanoporous (average pore size: about 350 nm) structure for the sample obtained under... 

    The effects of thymus plant extracts on single breast cancer cell morphology in the microfluidic channel

    , Article 2018 IEEE EMBS Conference on Biomedical Engineering and Sciences, IECBES 2018, 3 December 2018 through 6 December 2018 ; 2019 , Pages 647-651 ; 9781538624715 (ISBN) Ahmad, M. R ; Mansor, M. A ; Alsadat Rad, M ; Soo-Beng Khoo, A ; Ahmad, M ; Marzuki, M ; Physiological Measurement; Sarawak Convention Bureau ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2019
    Microfluidics based systems could be useful for drug discovery as they allow for miniaturization and could potentially be run as multiple parallel cell based assays. Such miniaturization allows assays at single cell level and reduces the amount of test material needed, which, in the case of natural product extracts, simplifies the preparation. Thyme species extracts have been reported to show some promising anti-cancer effects. In the present work, we used a microfluidics based system to study the effects of Thymus kotschyanusm Boiss plant extract on two human breast cancer cells lines which are MDA-MB-231 and MCF-7. For better understanding a single cancer cell death mechanism and a flow... 

    Chemical constituents of dichloromethane extract of cultivated Satureja khuzistanica

    , Article Evidence-based Complementary and Alternative Medicine ; Volume 4, Issue 1 , 2007 , Pages 95-98 ; 1741427X (ISSN) Matloubi Moghaddam, F ; Farimani, M. M ; Salahvarzi, S ; Amin, G ; Sharif University of Technology
    Four compounds β-sitosterol, β-sitosterol-3-O-β-D- glucopyranoside, ursolic acid and 4′,5,6-trihydroxy-3′,7- dimethoxyflavone were characterized from the dichloromethane extract of the aerial parts of Satureja khuzistanica (Lamiaceae), a native medicinal plant growing in Iran, on the basis of spectral analysis and comparing with the data in literature. The natural occurrence of these compounds can be conclusive for the chemotaxonomic characterization of the genus Satureja. © 2006 The Author(s)  

    Biosynthesis of copper oxide nanoparticles with potential biomedical applications

    , Article International Journal of Nanomedicine ; Volume 15 , 2020 , Pages 3983-3999 Rabiee, N ; Bagherzadeh, M ; Kiani, M ; Ghadiri, A. M ; Etessamifar, F ; Jaberizadeh, A. H ; Shakeri, A ; Sharif University of Technology
    Dove Medical Press Ltd  2020
    Introduction: In recent years, the use of cost-effective, multifunctional, environmentally friendly and simple prepared nanomaterials/nanoparticles have been emerged considerably. In this manner, different synthesizing methods were reported and optimized, but there is still lack of a comprehensive method with multifunctional properties. Materials and Methods: In this study, we aim to synthesis the copper oxide nanoparticles using Achillea millefolium leaf extracts for the first time. Catalytic activity was investigated by in situ azide alkyne cycloaddition click and also A3 coupling reaction, and optimized in terms of temperature, solvent, and time of the reaction. Furthermore, the... 

    Synthesis of green benzamide-decorated UiO-66-NH2 for biomedical applications

    , Article Chemosphere ; Volume 299 , 2022 ; 00456535 (ISSN) Rabiee, N ; Ghadiri, A. M ; Alinezhad, V ; Sedaghat, A ; Ahmadi, S ; Fatahi, Y ; Makvandi, P ; Saeb, M. R ; Bagherzadeh, M ; Asadnia, M ; Varma, R. S ; Lima, E. C ; Sharif University of Technology
    Elsevier Ltd  2022
    Metal-organic frameworks (MOFs) biocompatible systems can host enzymes/bacteria/viruses. Herein we synthesized a series of fatty acid amide hydrolase (FAAH)-decorated UiO-66-NH2 based on Citrus tangerine leaf extract for drug delivery and biosensor applications. Five chemically manipulated FAAH-like benzamides were localized on the UiO-66-NH2 surface with physical interactions. Comprehensive cellular and molecular analyses were conducted on HEK-293, HeLa, HepG2, PC12, MCF-7, and HT-29 cell lines (cytotoxicity assessment after 24 and 48 h). MTT results proved above 95 and 50% relative cell viability in the absence and presence of the drug, respectively. A complete targeted drug-releasing... 

    Dynamic stereochemistry of rutin (vitamin P) in solution: Theoretical approaches and experimental validation

    , Article Carbohydrate Research ; Volume 345, Issue 12 , 2010 , Pages 1760-1766 ; 00086215 (ISSN) Ghiasi, M ; Taheri, S ; Tafazzoli, M ; Sharif University of Technology
    The 3D structure of vitamin P, an important bioflavonoid, has been studied in solution by 2D NMR spectroscopy and QM calculations. Rutin, vitamin P, was extracted from Salvia macrosiphon and identified by 1H, 13C, 1H-1H COSY, HMQC, and HMBC spectroscopy. In parallel, density functional theory (DFT) using B3LYP functional and split-valance 6-311G basis set has been used to optimize the structures and conformers of rutin. Also experimental and theoretical methods have been used to correlate the dependencies of 1J, 2J, and 3J involving 1H and 13C on the C5″-C6″ (ω), C6″-O6″ (θ), and C1‴-O6″ () torsion angles in the glycosidic moiety. New Karplus equations are proposed to assist in the... 

    Self-modeling curve resolution techniques applied to comparative analysis of volatile components of Iranian saffron from different regions

    , Article Analytica Chimica Acta ; Volume 662, Issue 2 , 2010 , Pages 143-154 ; 00032670 (ISSN) Jalali Heravi, M ; Parastar, H ; Ebrahimi Najafabadi, H ; Sharif University of Technology
    Volatile components of saffron from different regions of Iran were extracted by ultrasonic-assisted solvent extraction (USE) and were analyzed by gas chromatography-mass spectrometry (GC-MS). Self-modeling curve resolution (SMCR) was proposed for resolving the co-eluted GC-MS peak clusters into pure chromatograms and mass spectra. Multivariate curve resolution-objective function minimization (MCR-FMIN) and multivariate curve resolution-alternating least square (MCR-ALS) were successfully used for this purpose. The accuracy of the qualitative and quantitative results was improved considerably using SMCR techniques. Comparison of the results of saffron from different regions of Iran showed... 

    Physical, morphological, and biological studies on PLA/nHA composite nanofibrous webs containing equisetum arvense herbal extract for bone tissue engineering

    , Article Journal of Applied Polymer Science ; Volume 134, Issue 39 , 2017 ; 00218995 (ISSN) Khakestani, M ; Jafari, S. H ; Zahedi, P ; Bagheri, R ; Hajiaghaee, R ; Sharif University of Technology
    A series of herbal extract incorporated into poly(lactic acid) (PLA) composite nanofibrous scaffolds were successfully prepared by using electrospinning technique. Equisetum arvense extract (EE) and nanohydroxyapatite (nHA) in different quantities were loaded into PLA solution to fabricate composite nanofibrous webs under various electrospinning conditions. Uniform nanofibers were obtained with an average diameter of 157 ± 47 nm in the case of those containing the herbal extract. Characterization of the webs was carried out by means of Fourier transform infrared (FTIR) spectroscopy, field emission-scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), and...