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Stability of Atherosclerotic Arteries Using Fluid-structure Interaction
, M.Sc. Thesis Sharif University of Technology ; Fallah, Famida (Supervisor)
Abstract
Tortuosity is an abnormality that may occur in some arteries, such as carotid. It can reduce the blood flow to distal organs, and even in severe cases, causes ischemia and stroke. Tortuosity can be congenital or occurs due to hypertension and reduced axial pre-stretch of artery, in which case called buckling. Since atherosclerotic plaques disrupt the normal pattern of blood flow, and thus make the artery more susceptible to buckling, in this study, the effect of atherosclerotic plaques on arterial stability has been investigated using computational simulation of fluid-structure interaction under pulsatile flow and large deformation. Ideal geometry of normal and atherosclerotic carotid artery...
Stability of Coronary Arteries Arteriosclerosis Using Fluid-Structure Interaction
, M.Sc. Thesis Sharif University of Technology ; Fallah Ragabzadeh, Famida (Supervisor)
Abstract
Coronary arteries often experience tortuosity under internal blood pressure and longitude axial twisting. Arterial tortuosity can enhance the stress concentration on the artery walls. Now if the coronary arteries suffer from atherosclerosis (a common disease among adults) the stress concentration on the tortuous artery plaque will be enhanced as well. Increased stress on the plaque may result in plaque rupture and its consequent damages. This study aims to investigate the stress concentration on the plaques and blood flow patterns within the coronary arteries with plaque. Moreover, the plaque growth was predicted taking into account various geometrical parameters including fibrous cap...
Plaque structure affects mechanical stress distribution within blood vessels
, Article Proceedings of the IASTED International Conference on Biomedical Engineering, BioMed 2014 ; 2014 , pp. 239-243 ; Mehboudi, N ; Abdollahi, M ; Shamloo, A ; Naghdabadi, R ; Sharif University of Technology
Abstract
The main goal of this study is to investigate the effects of plaque structure on its stress distribution. Rupture of plaque causes cerebrovascular diseases which lead to high mortality rates all over the world. Computers are powerful tools to understand the mechanism of plaque rupture. In this study, 3D fluid structure interaction simulation is constructed in ABAQUS 6.13 to clarify the relation between stress distribution of plaque and its structure. A model of common carotid artery with distributed stenosis was chosen for the simulation. To investigate the effects of plaque structure on stress distribution, thickness of fibrous cap and lipid core size were varied in the stenosis....
Investigation of coronary artery tortuosity with atherosclerosis: A study on predicting plaque rupture and progression
, Article International Journal of Mechanical Sciences ; Volume 223 , 2022 ; 00207403 (ISSN) ; Fallah, F ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
This study investigated the effects of different patterns of coronary artery tortuosity (CAT) on the stress concentration of the plaques and the blood flow pattern inside an atherosclerotic artery to predict the risk of plaque rupture and progression. Four different loadings of the coronary artery, including pulsatile blood pressure as well as one-end twist around the artery axis at blood pressures of 74, 100, and 120 mmHg were considered. No study has addressed bent and twist buckling of an atherosclerotic artery considering pulsatile flow (for bent buckling), fluid-solid interaction, and different geometrical parameters of the plaque. The results showed that C-shape tortuosity under...