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    A regenerative approach towards recovering the mechanical properties of degenerated intervertebral discs: Genipin and platelet-rich plasma therapies

    , Article Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 231, Issue 2 , 2017 , Pages 127-137 ; 09544119 (ISSN) Nikkhoo, M ; Wang, J. L ; Abdollahi, M ; Hsu, Y. C ; Parnianpour, M ; Khalaf, K ; Sharif University of Technology
    SAGE Publications Ltd  2017
    Abstract
    Degenerative disc disease, associated with discrete structural changes in the peripheral annulus and vertebral endplate, is one of the most common pathological triggers of acute and chronic low back pain, significantly depreciating an individual's quality of life and instigating huge socioeconomic costs. Novel emerging therapeutic techniques are hence of great interest to both research and clinical communities alike. Exogenous crosslinking, such as Genipin, and platelet-rich plasma therapies have been recently demonstrated encouraging results for the repair and regeneration of degenerated discs, but there remains a knowledge gap regarding the quantitative degree of effectiveness and... 

    Hybrid System for Growth Factor Delivery

    , M.Sc. Thesis Sharif University of Technology Torabi Rahvar, Parisa (Author) ; Abdekhodaie, Mohammad Jafar (Supervisor)
    Abstract
    Platelet Rich Plasma (PRP) is a blood-derived product containing concentrate of platelets, which are a rich source of autologous growth factors. PRP injection has been used clinically as a therapeutic method for cartilage repair. However, clinical efficiency of this method is unpredictable, maybe as a result of burst release of growth factors then fail cell-stimulating potential as most biomolecules are cleaned before they can exert a therapeutic effect. The aim of this project was to prepare a suitable scaffold for PRP delivery to regenerate cartilage injuries. In order to resemble polysaccharide-protein nature of the cartilaginous extracellular matrix, in this study, we developed an... 

    Calculating Runoff Coefficient of Urmia Lake Basin by Empirical Models and Remot Sensing (RS) Technology

    , M.Sc. Thesis Sharif University of Technology Akbari, Mahdi (Author) ; Tajrishy, Masoud (Supervisor) ; Arasteh, Peyman (Co-Advisor)
    Abstract
    Estimation of runoff in the ungauged basins is a challenge for hydrologists. The main objective of this research is to produce runoff coefficient map using SCS-CN (1972) and Kennessey (1930) as empirical models to for Urmia Lake basin between for 2006-2011.Both SCS-CN and Kennessey methods use slope, land use, and soil permeability data to estimate surface runoff. Accuracy of each model is tested along with the observed runoff using the Root Mean Square Error (RMSE).Urmia Lake basin includes about 400,000 hectares irrigated land, which constitutes around 10 percent of the entire basin area. To exclude the anthropological activities from the estimations, methods were applied only for 28...