Loading...
Search for:
pmma-substrates
0.005 seconds
High throughput blood plasma separation using a passive PMMA microfluidic device
, Article Microsystem Technologies ; 2015 ; 09467076 (ISSN) ; Shamloo, A ; Mohammadaliha, N ; Hajghassem, H ; Mehrabadi, J. F ; Bazzaz, M ; Sharif University of Technology
Springer Verlag
2015
Abstract
Since plasma is rich in many biomarkers used in clinical diagnostic experiments, microscale blood plasma separation is a primitive step in most of microfluidic analytical chips. In this paper, a passive microfluidic device for on-chip blood plasma separation based on Zweifach–Fung effect and plasma skimming was designed and fabricated by hot embossing of microchannels on a PMMA substrate and thermal bonding process. Human blood was diluted in various times and injected into the device. The main novelty of the proposed microfluidic device is the design of diffuser-shaped daughter channels. Our results demonstrated that this design exerted a considerable positive influence on the separation...
High throughput blood plasma separation using a passive PMMA microfluidic device
, Article Microsystem Technologies ; Volume 22, Issue 10 , 2016 , Pages 2447-2454 ; 09467076 (ISSN) ; Shamloo, A ; Mohammadaliha, N ; Hajghassem, H ; Fallah Mehrabadi, J ; Bazzaz, M ; Sharif University of Technology
Springer Verlag
2016
Abstract
Since plasma is rich in many biomarkers used in clinical diagnostic experiments, microscale blood plasma separation is a primitive step in most of microfluidic analytical chips. In this paper, a passive microfluidic device for on-chip blood plasma separation based on Zweifach–Fung effect and plasma skimming was designed and fabricated by hot embossing of microchannels on a PMMA substrate and thermal bonding process. Human blood was diluted in various times and injected into the device. The main novelty of the proposed microfluidic device is the design of diffuser-shaped daughter channels. Our results demonstrated that this design exerted a considerable positive influence on the separation...