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Manufacture of Smart Drug Delivery System with UCST Polymers
, M.Sc. Thesis Sharif University of Technology ; Ramazani, Ahmad (Supervisor)
Abstract
Smart heat-sensitive polymers play a unique role in drug delivery systems due to reversible behavior in response to environmental changes, especially temperature changes. Among the heat-sensitive polymers, UCST polymers due to their specific behavior and very little-known polymers with this feature are the subject of many new researches. In the present study, New designed temperature-sensitive polymers with UCST capability based on acrylamide and vinyl acetate were synthesized. These copolymers were synthesized in different percentages of acrylamide by free radical polymerization in solution conditions. All polymers compounds were characterized by H-NMR, FT-IR, DSC and GPC measurements. The...
Bacterial components as naturally inspired nano-carriers for drug/gene delivery and immunization: set the bugs to work?
, Article Biotechnology Advances ; Volume 36, Issue 4 , 2018 , Pages 968-985 ; 07349750 (ISSN) ; Moghoofei, M ; Mirkiani, S ; Ghasemi, A ; Rabiee, N ; Hadifar, S ; Beyzavi, A ; Karimi, M ; Hamblin, M. R ; Sharif University of Technology
Elsevier Inc
2018
Abstract
Drug delivery is a rapidly growing area of research motivated by the nanotechnology revolution, the ideal of personalized medicine, and the desire to reduce the side effects of toxic anti-cancer drugs. Amongst a bewildering array of different nanostructures and nanocarriers, those examples that are fundamentally bio-inspired and derived from natural sources are particularly preferred. Delivery of vaccines is also an active area of research in this field. Bacterial cells and their components that have been used for drug delivery, include the crystalline cell-surface layer known as “S-layer” bacterial ghosts, bacterial outer membrane vesicles, and bacterial products or derivatives (e.g....