Sharif Digital Repository

In the present research, two types of drug carriers based on mesoporous silica-coated magnetic graphene oxide, Fe3O4@GO@mSiO2, were synthesised and the pH-responsive behaviour for doxorubicin release was investigated. One type of the carrier was dendrimer-like multi ethylene amine grafted on Fe3O4@GO@mSiO2 and the other was dendrimer-like supramolecular polypseudorotaxane. Herein, α-cyclodextrin was used in the structure of supramolecular nanoparticles as a gatekeeper to inhibit the drug from escaping at neutral pH (the pH of healthy tissue). The drug release profile showed that the supramolecular nanocarrier was more sensitive to the pH changes. The content of drug release was about 100% at... 

Chitosan based polyseudorotaxane was designed as a pH-responsive supramolecular polymeric shell around the mesoporous silica-coated magnetic graphene oxide (Fe3O4@GO@mSiO2). It was used for doxorubicin delivery at cancerous tissue in a controlled manner. The core-shell nanocarrier was formed due to electrostatic interaction between chitosan and carboxylated surface of Fe3O4@GO@mSiO2. The maximum release occurred at pH 5.5 (pH of endosomes) because the shell collapsed at this pH. The drug nanocarrier has potential application in tumor therapy due to good pH-sensitive behavior, improved solubility and high colloidal stability in...