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ponceau-4r
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Studies of Ponceau 4R food colorant and zinc oxide nanoparticles containing it interactions with DNA and evaluation of their antimicrobial activity
, Article Journal of Food Processing and Preservation ; Volume 46, Issue 2 , 2022 ; 01458892 (ISSN) ; Shahabadi, N ; Mahmoudi Hashemi, M ; Meibodi, F. S ; Mirjafari, Z ; Sharif University of Technology
John Wiley and Sons Inc
2022
Abstract
The current study describes design and synthesis of silica-coated zinc oxide nanoparticles containing Ponceau 4R food colorant (named as ZnO@SiO2@APTMS/P4R). The interactions of Ponceau 4R and ZnO@SiO2@APTMS/P4R with calf thymus-DNA were investigated It should be noted that the competitive binding experiment revealed that both Ponceau 4R and ZnO@SiO2@APTMS/P4R could release Hoechst 33258. As inferred from the results the binding of the Ponceau 4R and ZnO@SiO2@APTMS/P4R with DNA were surface binding, mainly due to groove binding. Furthermore, antibacterial properties of ZnO, Ponceau 4R and ZnO@SiO2@APTMS/P4R samples against gram-positive bacteria and gram-negative bacteria were examined and...
Electrochemical determination of clozapine on MWCNTs/new coccine doped ppy modified GCE: An experimental design approach
, Article Bioelectrochemistry ; Volume 90 , 2013 , Pages 36-43 ; 15675394 (ISSN) ; Kamalzadeh, Z ; Hamzehloei, A ; Sharif University of Technology
2013
Abstract
The electrooxidation of clozapine (CLZ) was studied on the surface of a glassy carbon electrode (GCE) modified with a thin film of multiwalled carbon nanotubes (MWCNTs)/new coccine (NC) doped polypyrrole (PPY) by using linear sweep voltammetry (LSV). The pH of the supporting electrolyte (D), drop size of the cast MWCNTs suspension (E) and accumulation time of CLZ on the surface of modified electrode (F) was considered as effective experimental factors and the oxidation peak current of CLZ was selected as the response. By using factorial-based response-surface methodology, the optimum values of factors were obtained as 5.44, 10 μL and 300 s for D, E and F respectively. Under the optimized...